10 ENGLISH BOOKS RELATING TO «AMINOPTERIN»
Discover the use of
aminopterin in the following bibliographical selection. Books relating to
aminopterin and brief extracts from same to provide context of its use in English literature.
1
Drugs and Nutrients: The Interactive Effects
Folic Acid Aminopterin and methotrexate: Animal studies Early research with
vitamins involved in single-carbon metabolism showed that the feeding of 4-
aminopteroylglutamic acid (aminopterin) , an antagonist of folic acid, resulted in
reduced ...
2
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal ...
Long- term studies of growth and mental development in offspring exposed to
aminopterin during the 2nd trimester, the period of neuroblast multiplication, have
not been conducted (9). BREASTFEEDING SUMMARY No reports describing the
...
Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe, 2011
3
Rat Hybridomas and Rat Monoclonal Antibodies
Aminopterin 100 x (Gibco No. 043.013621) or aminopterin (Sigma No. A-1784)
13. Trypan blue solution (Gibco No. 043-05250-H) 14. Tilrk1s solution (Merck No.
9277) 15. Fusion medium: in a clean glass beaker, weigh 5 g polyethylene ...
4
The Treatment of Cancer: With Special Reference to ...
aminopterin, because its terminal aspartic acid, with one carbon atom less in the
amino acid chain, is unlikely to allow a ring closure. (3) As a ring closure would
involve the loss of the free COOH-group in the y-position of glutamic acid, only ...
Joseph Stanley Mitchell, 1965
The use of methotrexate in non-neoplastic diseases In 1951, Gubner reported
that aminopterin suppressed the exudative and proliferative responses to the
injection of formalin in the paws of rats [46]. Soon after, he and his colleagues ...
Bruce N. Cronstein, Joseph R. Bertino, 2000
6
ADVANCES IN CANCER RESEARCH
Human Vogt (1959) isolated variants of HeLa (Gey et al., 1952) resistant to
aminopterin commencing selection at 1 X 10"8 M and increasing gradually to in
some cases 1.1 X 10'6 M. The plating efficiency of aminopterin-resistant cells in
the ...
7
Monoclonal Antibody Technology: The Production and ...
Laboratory protocols vary widely in their recommendations about feeding. The
following principles should be noted: (i) Aminopterin inhibits many normal cell
functions and should be removed from the feeding medium as soon as possible.
8
Pharmaceutical Biotechnology
(5) Aminopterin acts on the major synthetic pathway (or De Novo Biosynthesis)
by interfering directly with the conversion of dihydrofolate (FH2) to
tetrahydrofolate (FH4) and also preventing a series of one-carbon transfers
particularly. Hence ...
9
Human Developmental Toxicants: Aspects of Toxicology and ...
Drug-induced malformations in humans. In Drug Use in Pregnancy, L. Stern, Ed.,
Adis Health Science Press, Balgowlah, Australia, pp. 99–133. Howard, N. J. and
Rudd, N. L. (1977). The natural history of aminopterin-induced embryopathy.
James L. Schardein, Orest T. Macina, 2006
10
First Symposium on Chemical-biological Correlation, May ...
It seemed to us possible, then, that aminopterin, the 4-amino analogue of folic
acid, might block specifically this "activation" of folic acid. As Dr. Schoenbach has
pointed out, many have wondered whether aminopterin functions exclusively by ...
National Research Council (U.S.). Chemical-Biological Coordination Center, 1951
10 NEWS ITEMS WHICH INCLUDE THE TERM «AMINOPTERIN»
Find out what the national and international press are talking about and how the term
aminopterin is used in the context of the following news items.
What I Hope Everyone Learns From PBS' Big Cancer Documentary
That goes for aminopterin, the Lederle drug that, in the hands of the legendary Sidney Farber, produced the first remission in children with ... «Forbes, Mar 15»
Clinical trials pave the way to cancer care
... against the advice of more conservative colleagues, began treating children with aminopterin, a highly toxic drug that starved their cancerous ... «Sarasota Herald-Tribune, Mar 15»
Ken Burns traces history of cancer in new PBS documentary
... and, using a new folic-acid-antagonist drug called aminopterin, brought about temporary remissions in many of his young leukemia patients. «NorthJersey.com, Mar 15»
Sidney Farber and Lifting the Shame of Cancer
... short by this relentless disease, thought the answer may lie in subjecting his young patients to a rare and possibly dangerous compound called aminopterin. «Yahoo News, Mar 15»
The Road to Cancer Treatment Through Clinical Trials
... against the advice of more conservative colleagues, began treating children with aminopterin, a highly toxic drug that starved their cancerous ... «New York Times, Mar 15»
Thank a White Male
Sidney Farber in the late '40s carried out clinical trials with the antifolate aminopterin, synthesized at Lederle by the Indian biochemist ... «American Thinker, Nov 14»
ASCO President on the Triumph of the Open Mind
Dr. Holland: I treated a 4-year-old girl -- named Jennifer -- who had acute leukemia with aminopterin, and she went into remission and it was ... «Medscape, Jun 14»
A short history of chemotherapy
That compound — aminopterin — was the predecessor of methotrexate, a cancer treatment drug that is still used commonly today. Researchers ... «Ottawa Citizen, May 14»
Obama Nominates Julian Castro as HUD Secretary
And when that I wanna give both of Aminopterin is very few words -- -- -- was -- Thank you so much Mr. President. At first heard the name ... «ABC News, May 14»
Chemists' work will aid drug design to target cancer and …
This image shows models of the human folate receptor (top) and antifolate drugs used in chemotherapy (bottom, from left: aminopterin, ... «Phys.Org, Aug 13»
