10 ENGLISH BOOKS RELATING TO «GENOTOXIC»
Discover the use of
genotoxic in the following bibliographical selection. Books relating to
genotoxic and brief extracts from same to provide context of its use in English literature.
1
Genotoxic Impurities: Strategies for Identification and Control
This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective.
2
The Cellular Response to the
Genotoxic Insult: The Question ...
This book considers the exposure levels at which genotoxins pose a risk and describes the cellular mechanisms used against them.
Helmut Greim, Richard J. Albertini, 2012
3
Short-term toxicity tests for non-
genotoxic effects
Presents the results of in vitro studies on cell cultures involving primarily undifferentiated cells, systematic examination of the function of organs and the hematopoietic, immunologic, reproductive and other systems.
Philippe Bourdeau, International Council of Scientific Unions. Scientific Committee on Problems of the Environment, 1990
4
Process Chemistry in the Pharmaceutical Industry: Challenges ...
Regulatory authorities generally expect sponsors of clinical trials and commercial
marketing authorizations to demonstrate the removal of potentially genotoxic
impurities or control them to minute levels in the ppm range. There are also ...
Kumar Gadamasetti, Tamim Braish, 2007
5
Risk Assessment of Chemicals: An Introduction
Carcinogens acting via genetic alteration are called genotoxic carcinogens; this
contrasts with non-genotoxic carcinogens, which do not damage DNA but
become active in the development of cancer after the first step of cancer
causation.
C.J. van Leeuwen, T.G. Vermeire, 2007
6
Genotoxic Air Pollutants: Genotoxicity of Smoke Emissions, ...
7
Going Against the Grain: DNA Excision Repair is Required for ...
Using TLS-(rev3 and rad30) and NER/TLS- (rad1, rad1 rev3 and rad1 rad30) deficient yeast, we made the novel observation that NER (rad1) is functioning in coordination with TLS error-prone bypass polymerase (rev3).
Bradford Raymond Brooks, 2008
8
Principles and Methods of Toxicology, Fifth Edition
Such agents are classified as genotoxic. The term genotoxic is a general
descriptor used to distinguish chemicals that have an intrinsic affinity for DNA
from those that do not. Genotoxic substances have several common chemical or
physical ...
9
Principles of Genetic Toxicology
Significance of the Classes of Genotoxic Effects In assessing the potential
forgenotoxic agents to induce health effects in humans, the nature of the lesion
becomes important. The reason is that many measures of genotoxicity are not
known per ...
10
Metal Ions in Toxicology: Effects, Interactions, ...
Risk assessment of chemicals in humans relies on a mechanistic assumption that
such chemicals may either be genotoxic or non-genotoxic. Genotoxic
carcinogens and their metabolites are assumed to act via a mode of action that
involves a ...
Astrid Sigel, Helmut Sigel, Roland K. O. Sigel, 2011
10 NEWS ITEMS WHICH INCLUDE THE TERM «GENOTOXIC»
Find out what the national and international press are talking about and how the term
genotoxic is used in the context of the following news items.
Plymouth University to host conference on damaging mutation of …
... origins of mutations could help with the testing process of chemicals used for medicine, industry and agriculture for their “genotoxic” effects. «Plymouth Herald, Jul 15»
Bosses of Bradford bakery admit using banned chemical to colour …
It is not a permitted food additive and is considered to be carcinogenic and genotoxic. It is commonly used in the sewerage industry as an industrial chemical ... «Bradford Telegraph and Argus, Jul 15»
FDA provides guidance on assessing potential risks to embryo/fetal …
... and developmental toxicity of the pharmaceutical; the cytotoxic or genotoxic properties of the drug; pharmacologic properties suggesting risk; ... «Lexology, Jul 15»
Regulation of DNA Damage Signaling and Cell Death Responses …
... LMP2A were coexpressed in the EBV-negative NPC cell line HK1 and examined for combined effects in response to genotoxic treatments. «Journal of Virology, Jul 15»
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in …
However, little is known about the posttranslational mechanisms by which FOXM1 expression is regulated by genotoxic agents and how they ... «Nature.com, Jul 15»
VISA - Vector Integration Site Analysis server: a web-based server to …
Analyzing the integration profile of retroviral vectors is a vital step in determining their potential genotoxic effects and developing safer vectors ... «BMC Blogs Network, Jul 15»
RING finger protein 31 promotes p53 degradation in breast cancer …
The p53-mediated pathways are activated by genotoxic compounds, such as the chemotherapeutic compound cisplatin, causing cell cycle ... «Nature.com, Jul 15»
Structural basis of how stress-induced MDMX phosphorylation …
... the precise physiological role of MDM2/MDMX phosphorylation and how it switches on the p53 pathway in response to genotoxic stress. «Nature.com, Jul 15»
Familial chronic lymphocytic leukemia in two siblings with ATM …
PubMed |; Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 2013; ... «Nature.com, Jul 15»
Chromosome territory repositioning induced by PHA-activation of …
CTs are susceptible to movement upon induction by a variety of stimuli, including: cell differentiation, growth factors, genotoxic agents, ... «7thSpace Interactive, Jul 15»
