10 ENGLISH BOOKS RELATING TO «GYRASE»
Discover the use of
gyrase in the following bibliographical selection. Books relating to
gyrase and brief extracts from same to provide context of its use in English literature.
1
Molecular Biology: Academic Cell Update Edition
Ciprofloxacin kills bacteria by inhibiting DNA gyrase. It is harmless to animals as
they do not use DNA gyrase for compacting their DNA. Supercoiled DNA One
strand passed through nick and resealed Strand nick Type I topoisomerases one
...
2
Cancer Research Supported Under Biomed1
Comparison of drug-promoted DNA cleavage mediated by topoisomerase II and
hy DNA gyrase (Milan, Newcastle and London) Mammalian topoisomerase II
shares structural, functional and mechanistic features with DNA gyrase, the ...
392 Other Functions of DNA Gyrase chapter 12: Cells maintain the superhelicity
of the chromosome within rather narrow Topoisomerases limits. This homeostatic
control is achieved by the antagonistic actions of gyrase and topo I.76 Some of ...
Arthur Kornberg, Tania A. Baker, 2005
4
Infectious Diseases in Immunocompromised Hosts
Currently, two major mechanisms have been defined: (1) alterations in the
bacterial DNA gyrase, the molecular target of the quinolone action; and (2)
reduction of drug accumulation in the cells.9" 10.2.3.1 Alterations in Bacterial
DNA Gyrase ...
Vassil St. Georgiev, 1997
5
Cell and Molecular Biology of Plastids
1989); E. coli gyrase is comprised of 95 kDa gyrase B and 105 kDa gyrase A
subunits (Reece and Maxwell 1991). A more recent proteomic study identified
gyrase A- and B-like subunits in proteinnucleic acid particles from purified P.
sativum ...
6
Bacterial Genomes: Physical Structure and Analysis
mutant but not in a gyrase mutant (Adams et al, 1992). However, gyrase does
seem to be capable of replacing topoisomerase IV if overexpressed. Gyrase may
supplement topoisomerase IV, since shifting a temperature-sensitive gyrase ...
F.J. de Bruijn, James R. Lupski, George M. Weinstock, 1998
7
Molecular Biology of DNA Topoisomerases and Its Application ...
DNA gyrase: structure and function. CRC Crii. Rev. Biochem MolBioL.2b. 335.
199L 4. Gellert. M.. Mizuuchi. K.. O'Dea. M. H.. and Nash. H. A.. DNA gyrase: an
enzyme that introduces superhelical turus into DNA. Proc. Natl Acad. Sci. USA..
73.
Toshiwo Andoh, Masao Oguro, Hideo Ikeda, 1992
8
Hyperthermophilic Enzymes
and ParE, which are homologous to GyrA and GyrB, respectively.9 However,
Topo IV has no DNA gyrase activity but, as is the case with the eukaryotic
enzyme, can relax both positively and negatively supercoiled DNA.10 In the
absence of ...
9
Links Between Recombination and Replication: Vital Roles of ...
and not (+), the true substrates for unlinking during replication. This is because
the systems used to produce the stalled replication intermediates contained
sufficient DNA gyrase to (?) supercoil the intermediates before or after stalling.
Proceedings of the National Academy of Sciences, 2002
10
Technological and Medical Implications of Metabolic Control ...
will lead to a change in DNA supercoiling, which in turn leads to a change in
transcription rates of topoisomerase I and DNA gyrase genes. Thus a change in
the level of DNA supercoiling in the global steady state is not only the result of the
...
Athel Cornish-Bowden, Maria Luz Cárdenas, 2000
10 NEWS ITEMS WHICH INCLUDE THE TERM «GYRASE»
Find out what the national and international press are talking about and how the term
gyrase is used in the context of the following news items.
So You Actually Drank the Water During Your Vacation?
Like other fluoroquinolones, ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV. It is bactericidal, and active against Gram ... «MedPage Today, Jun 15»
Choppy waters
The standalone company will deal with early stage antibiotics R&D including the novel gyrase inhibitor AZD0914, currently in phase II for the ... «Financial Express, Jun 15»
Say it with proteins: an alphabet of crystal structures
... recognition; and for proteins with holes that enclose DNA (A, from DNA gyrase) or puncture the membrane (O, from the toxin cytolysin A). «Nature.com, May 15»
AstraZeneca spins out early-stage R&D for antibiotic compounds
The new unnamed company will take over development of AstraZeneca's novel gyrase inhibitor AZD0914 for gonorrhoea, currently in phase ll ... «The Pharmaceutical Journal, Mar 15»
Antibiotic linked to nerve damage
All Fluoroquinolone Antibiotics are Topoisomerase Inhibitors, which means they work by attacking DNA gyrase and topoisomerase IV on ... «KING5.com, Mar 15»
AZ spins out antibiotics R&D biz to focus on key pipelines
The stand-alone company will exclusively deal with early-stage antibiotics R&D, including the novel gyrase inhibitor AZD0914, currently in ... «In-PharmaTechnologist.com, Mar 15»
AstraZeneca to spin off anti-infectives research
The new company's principal asset will be the novel gyrase inhibitor AZD0914, which is currently in Phase II clinical trials for treating ... «Royal Society of Chemistry, Mar 15»
AstraZeneca Launches $40M Early-Stage Anti-Infectives R&D Unit
The new subsidiary will focus exclusively on R&D for AstraZeneca's early-stage antibiotic pipeline, including the gyrase inhibitor AZD0914, now ... «Genetic Engineering & Biotechnology News, Feb 15»
Cystic Fibrosis Drug Quinsair For Pseudomonas Aeruginosa …
Specifically, the drug acts by inhibiting important bacteria enzymes for DNA replication, the bacterial DNA gyrase and topoisomerase IV ... «Cystic Fibrosis News Today, Dec 14»
Researchers discover bacteria-killer from natural source
"We were able to show that cystobactamides act as gyrase inhibitors. They prevent the DNA of the bacteria from being compacted in a ... «HealthCanal.com, Dec 14»
