10 ENGLISH BOOKS RELATING TO «PLEIOTROPIC»
Discover the use of pleiotropic
in the following bibliographical selection. Books relating to pleiotropic
and brief extracts from same to provide context of its use in English literature.
Of Mice and Mutants: Pleiotropic
Effects on Lipid Metabolism ...
Niemann-Pick Type C (NP-C) disease is a fatal neurovisceral lysosomal storage disorder that results from impaired trafficking of endocytosed low density lipoprotein (LDL) derived cholesterol out of late endosomes/lysosomes.
The Distribution of Beneficial Mutations and Their ...
In this thesis, we address this problem by measuring the distribution of beneficial mutations and their pleiotropic effects using mutants of Burkholderia cenocepacia and Escherichia coli.
Sarah Gaffney Wrocklage, 2009
Mechanisms of Statin Action in Alzheimer's Disease
Moreover, inhibition of Rho family protein function reduces levels of APP C-terminal fragments (CTFs), resulting in decreased Abeta secretion.
Stephen Marc Ostrowski, 2008
Immunology: A Short Course
Because they affect the activity of many different cell types, these cytokines can
be said to have pleiotropic properties. For example, the development and
differentiation of bone-forming cells known as osteoblasts are regulated by a host
Richard Coico, Geoffrey Sunshine, 2009
Handbook on Immunosenescence: basic understanding and ...
Our own gerontological research with respect to the elucidation of the
pathogenesis of age-dependent diseases was always based on the concept of
pleiotropic antagonism (pleiotropic = Gr, multifunctional; antagonistic = Gr having
Tamas Fulop, Tamás Fülöp, 2009
Atherosclerosis Disease Management
22.214.171.124 Pleiotropic Effects of Statins Recent experimental and clinical studies
suggest that statins may exert vascular protective effects beyond cholesterol
reduction. The cholesterol-independent or pleiotropic effects of statins appear to
Jasjit S. Suri, Chirinjeev Kathuria, Filippo Molinari, 2010
Biology Today and Tomorrow with Physiology
pleiotropic. gene is one that influences multiple traits. Mutations in such genes
are associated with complex genetic disorders such as sickle-cell anemia (
Section 7.6), cystic fibrosis (Section 9.1), and Marfan syndrome. Marfan
syndrome can ...
Cecie Starr, Christine Evers, Lisa Starr, 2009
Utilization of Forward and Reverse Genetic Approaches to ...
M0# Target Proposed function Dose (ng) Phenotype | 504 zinc finger protein 36,
C3H type-like 1 Unknown Expressed in MHB, otic vesicle and retina 1.5
Pleiotropic 505 zinc finger protein 36, C3H type-like 1 Unknown Expressed in
MHB, otic ...
The Evolution of Adaptive Systems: The General Theory of ...
The most probable key to release of adaptive potential from the pleiotropic load
lies with gene duplication, which has already been identified as being a major
influence allowing facilitation of change to developmental modularity (Chapter 12
James Patrick Brock, 2000
Statins: The HMG CoA reductase inhibitors in perspective
Many drugs have multiple effects, and the statins may affect cardiovascular
disease in ways that could be more or less unrelated to their effect on plasma
concentrations of cholesterol.22"25 Such effects are termed pleiotropic,26 and
the range ...
Allan Gaw, MD, PhD, Christopher J Packard, MRCPath, DSc, James Shepherd, MB, ChB, PhD, FRCPath, FRCP(Glasg), 1999
10 NEWS ITEMS WHICH INCLUDE THE TERM «PLEIOTROPIC»
Find out what the national and international press are talking about and how the term pleiotropic
is used in the context of the following news items.
Human adipose-derived mesenchymal stem cells attenuate …
Leptin is an adipokine with pleiotropic actions that regulate food intake, energy metabolism, inflammation, and immunity . A recent study ... «BMC Blogs Network, Jul 15»
Network analysis of immunotherapy-induced regressing tumours …
Fourth, we applied a drug repurposing approach to the response-associated network data. This resulted in the identification of pleiotropic drugs ... «Nature.com, Jul 15»
Computational Prediction and Validation of BAHD1 as a Novel …
TNFR1, which is ubiquitously expressed, has pleiotropic functions related to cell immunity, survival, apoptosis and necrosis and can be ... «Nature.com, Jul 15»
Systems biology surveillance decrypts pathological transcriptome …
However, pleiotropic phenotype derangements induced by calreticulin deficiency challenge the identification of specific downstream ... «7thSpace Interactive, Jul 15»
Evidence for bystander signalling between human trophoblast cells …
TNF-α is a cytokine with pleiotropic effects, with critical regulatory roles in cell proliferation, differentiation and programmed cell death. TNF-α ... «Nature.com, Jul 15»
New Insights Suggest Thiocyanate Could Address Lung …
Cystic fibrosis (CF) is a pleiotropic disease, which means that a gene mutation influences more than one bodily system. CF occurs when there ... «Cystic Fibrosis News Today, Jul 15»
Gene therapy clinical trial underway for children's motor neuron …
GAN, like many single-gene diseases, is "pleiotropic" – it has several signs and symptoms. When patients present with different subsets of the ... «Medical Xpress, Jul 15»
Gene Variant May Affect Postnatal Growth
... that IGF-II, which is a known insulin-like mediator of intrauterine development, may contribute to postnatal growth and has pleiotropic effects. «MedPage Today, Jul 15»
PCSK9 Inhibitors vs. The Guidelines
... was better for cardiovascular risk reduction whatever the means used to get it there, rather than being a special pleiotropic benefit of statins. «MedPage Today, Jul 15»
The Pleiotropic Art of Medicine
The practice of medicine is complex. It's an art. Art can benefit from the adoption of new technology, growing in its robustness and expression. «Medscape, Jul 15»