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Meaning of "pleiotropic" in the English dictionary

Dictionary
DICTIONARY
section

PRONUNCIATION OF PLEIOTROPIC

pleiotropic  [ˌplaɪəʊˈtrɒpɪk] play
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GRAMMATICAL CATEGORY OF PLEIOTROPIC

noun
adjective
verb
adverb
pronoun
preposition
conjunction
determiner
exclamation
Pleiotropic is an adjective.
The adjective is the word that accompanies the noun to determine or qualify it.

WHAT DOES PLEIOTROPIC MEAN IN ENGLISH?

Pleiotropy

Pleiotropy occurs when one gene influences multiple, seemingly unrelated phenotypic traits, an example being phenylketonuria, which is a human disease that affects multiple systems but is caused by one gene defect. Consequently, a mutation in a pleiotropic gene may have an effect on some or all traits simultaneously. Pleiotropic gene action can limit the rate of multivariate evolution when natural selection, sexual selection or artificial selection on one trait favours one specific version of the gene, while selection on other traits favors a different allele. The underlying mechanism of pleiotropy in most cases is the effect of a gene on metabolic pathways that contribute to different phenotypes. Genetic correlations and hence correlated responses to selection are most often caused by pleiotropy.

Definition of pleiotropic in the English dictionary

The definition of pleiotropic in the dictionary is producing multiple effects.

WORDS THAT RHYME WITH PLEIOTROPIC


adrenocorticotropic
əˌdriːnəʊˌkɔːtəkəʊˈtrɒpɪk
allotropic
ˌæləˈtrɒpɪk
anisotropic
ænˌaɪsəʊˈtrɒpɪk
azeotropic
ˌeɪzɪəˈtrɒpɪk
entropic
ɛnˈtrɒpɪk
hydrotropic
ˌhaɪdrəʊˈtrɒpɪk
inotropic
ˌɪnəˈtrɒpɪk
ionotropic
aɪˌɒnəˈtrɒpɪk
isentropic
ˌaɪsɛnˈtrɒpɪk
isotropic
ˌaɪsəʊˈtrɒpɪk
lipotropic
ˌlɪpəʊˈtrɒpɪk
neurotropic
ˌnjʊərəˈtrɒpɪk
nyctitropic
ˌnɪktɪˈtrɒpɪk
orthotropic
ˌɔːθəʊˈtrɒpɪk
pantropic
pænˈtrɒpɪk
phototropic
ˌfəʊtəʊˈtrɒpɪk
psychotropic
ˌsaɪkəʊˈtrɒpɪk
thermotropic
ˌθɜːməʊˈtrɒpɪk
thixotropic
ˌθɪksəˈtrɒpɪk
tropic
ˈtrɒpɪk

WORDS THAT BEGIN LIKE PLEIOTROPIC

pleiad
Pleiades
plein-air
plein-airist
pleinairism
Pleiocene
pleiochasium
pleiomerous
pleiomery
pleiotaxy
pleiotropism
pleiotropy
Pleistocene
Plekhanov
plena
plenaries
plenarily
plenarty
plenary
plench

WORDS THAT END LIKE PLEIOTROPIC

anisometropic
anthropic
apheliotropic
diageotropic
emmetropic
gonadotropic
hydropic
hyperopic
lycanthropic
misanthropic
morphotropic
neotropic
nootropic
philanthropic
psilanthropic
somatotropic
stereotropic
subtropic
thyrotropic
topic
xenotropic

Synonyms and antonyms of pleiotropic in the English dictionary of synonyms

SYNONYMS

Translation of «pleiotropic» into 25 languages

TRANSLATOR
online translator

TRANSLATION OF PLEIOTROPIC

Find out the translation of pleiotropic to 25 languages with our English multilingual translator.
The translations of pleiotropic from English to other languages presented in this section have been obtained through automatic statistical translation; where the essential translation unit is the word «pleiotropic» in English.

Translator English - Chinese

多效
1,325 millions of speakers

Translator English - Spanish

pleiotrópicos
570 millions of speakers

English

pleiotropic
510 millions of speakers

Translator English - Hindi

pleiotropic
380 millions of speakers
ar

Translator English - Arabic

عديد المظاهر
280 millions of speakers

Translator English - Russian

плейотропный
278 millions of speakers

Translator English - Portuguese

pleiotrópica
270 millions of speakers

Translator English - Bengali

pleiotropic
260 millions of speakers

Translator English - French

pléiotropique
220 millions of speakers

Translator English - Malay

Pleiotropic
190 millions of speakers

Translator English - German

pleiotropen
180 millions of speakers

Translator English - Japanese

多面的な
130 millions of speakers

Translator English - Korean

다면 발현
85 millions of speakers

Translator English - Javanese

Pleiotropic
85 millions of speakers
vi

Translator English - Vietnamese

pleiotropic
80 millions of speakers

Translator English - Tamil

pleiotropic
75 millions of speakers

Translator English - Marathi

फुलांचा रोग
75 millions of speakers

Translator English - Turkish

pleiotropik
70 millions of speakers

Translator English - Italian

pleiotropici
65 millions of speakers

Translator English - Polish

plejotropową
50 millions of speakers

Translator English - Ukrainian

плейотропний
40 millions of speakers

Translator English - Romanian

pleiotropic
30 millions of speakers
el

Translator English - Greek

πλειοτροπικά
15 millions of speakers
af

Translator English - Afrikaans

pleiotropic
14 millions of speakers
sv

Translator English - Swedish

pleiotrop
10 millions of speakers
no

Translator English - Norwegian

pleiotropisk
5 millions of speakers

Trends of use of pleiotropic

TRENDS

TENDENCIES OF USE OF THE TERM «PLEIOTROPIC»

The term «pleiotropic» is regularly used and occupies the 90.493 position in our list of most widely used terms in the English dictionary.
0
100%
FREQUENCY
Regularly used
58
/100
The map shown above gives the frequency of use of the term «pleiotropic» in the different countries.
Principal search tendencies and common uses of pleiotropic
List of principal searches undertaken by users to access our English online dictionary and most widely used expressions with the word «pleiotropic».

FREQUENCY OF USE OF THE TERM «PLEIOTROPIC» OVER TIME

The graph expresses the annual evolution of the frequency of use of the word «pleiotropic» during the past 500 years. Its implementation is based on analysing how often the term «pleiotropic» appears in digitalised printed sources in English between the year 1500 and the present day.

Examples of use in the English literature, quotes and news about pleiotropic

EXAMPLES

10 ENGLISH BOOKS RELATING TO «PLEIOTROPIC»

Discover the use of pleiotropic in the following bibliographical selection. Books relating to pleiotropic and brief extracts from same to provide context of its use in English literature.
1
Of Mice and Mutants: Pleiotropic Effects on Lipid Metabolism ...
Niemann-Pick Type C (NP-C) disease is a fatal neurovisceral lysosomal storage disorder that results from impaired trafficking of endocytosed low density lipoprotein (LDL) derived cholesterol out of late endosomes/lysosomes.
Kevin P. Collins, 2007
2
The Distribution of Beneficial Mutations and Their ...
In this thesis, we address this problem by measuring the distribution of beneficial mutations and their pleiotropic effects using mutants of Burkholderia cenocepacia and Escherichia coli.
Sarah Gaffney Wrocklage, 2009
3
Pleiotropic Mechanisms of Statin Action in Alzheimer's Disease
Moreover, inhibition of Rho family protein function reduces levels of APP C-terminal fragments (CTFs), resulting in decreased Abeta secretion.
Stephen Marc Ostrowski, 2008
4
Immunology: A Short Course
Because they affect the activity of many different cell types, these cytokines can be said to have pleiotropic properties. For example, the development and differentiation of bone-forming cells known as osteoblasts are regulated by a host of ...
Richard Coico, Geoffrey Sunshine, 2009
5
Handbook on Immunosenescence: basic understanding and ...
Our own gerontological research with respect to the elucidation of the pathogenesis of age-dependent diseases was always based on the concept of pleiotropic antagonism (pleiotropic = Gr, multifunctional; antagonistic = Gr having the ...
Tamas Fulop, Tamás Fülöp, 2009
6
Atherosclerosis Disease Management
19.4.1.7 Pleiotropic Effects of Statins Recent experimental and clinical studies suggest that statins may exert vascular protective effects beyond cholesterol reduction. The cholesterol-independent or pleiotropic effects of statins appear to impact ...
Jasjit S. Suri, Chirinjeev Kathuria, Filippo Molinari, 2010
7
Biology Today and Tomorrow with Physiology
pleiotropic. gene is one that influences multiple traits. Mutations in such genes are associated with complex genetic disorders such as sickle-cell anemia ( Section 7.6), cystic fibrosis (Section 9.1), and Marfan syndrome. Marfan syndrome can ...
Cecie Starr, Christine Evers, Lisa Starr, 2009
8
Utilization of Forward and Reverse Genetic Approaches to ...
M0# Target Proposed function Dose (ng) Phenotype | 504 zinc finger protein 36, C3H type-like 1 Unknown Expressed in MHB, otic vesicle and retina 1.5 Pleiotropic 505 zinc finger protein 36, C3H type-like 1 Unknown Expressed in MHB, otic ...
Brent Roy Bill, 2008
9
The Evolution of Adaptive Systems: The General Theory of ...
The most probable key to release of adaptive potential from the pleiotropic load lies with gene duplication, which has already been identified as being a major influence allowing facilitation of change to developmental modularity (Chapter 12 ).
James Patrick Brock, 2000
10
Statins: The HMG CoA reductase inhibitors in perspective
Many drugs have multiple effects, and the statins may affect cardiovascular disease in ways that could be more or less unrelated to their effect on plasma concentrations of cholesterol.22"25 Such effects are termed pleiotropic,26 and the range ...
Allan Gaw, MD, PhD, Christopher J Packard, MRCPath, DSc, James Shepherd, MB, ChB, PhD, FRCPath, FRCP(Glasg), 1999

10 NEWS ITEMS WHICH INCLUDE THE TERM «PLEIOTROPIC»

Find out what the national and international press are talking about and how the term pleiotropic is used in the context of the following news items.
1
Human adipose-derived mesenchymal stem cells attenuate …
Leptin is an adipokine with pleiotropic actions that regulate food intake, energy metabolism, inflammation, and immunity [33]. A recent study ... «BMC Blogs Network, Jul 15»
2
Network analysis of immunotherapy-induced regressing tumours …
Fourth, we applied a drug repurposing approach to the response-associated network data. This resulted in the identification of pleiotropic drugs ... «Nature.com, Jul 15»
3
Computational Prediction and Validation of BAHD1 as a Novel …
TNFR1, which is ubiquitously expressed, has pleiotropic functions related to cell immunity, survival, apoptosis and necrosis and can be ... «Nature.com, Jul 15»
4
Systems biology surveillance decrypts pathological transcriptome …
However, pleiotropic phenotype derangements induced by calreticulin deficiency challenge the identification of specific downstream ... «7thSpace Interactive, Jul 15»
5
Evidence for bystander signalling between human trophoblast cells …
TNF-α is a cytokine with pleiotropic effects, with critical regulatory roles in cell proliferation, differentiation and programmed cell death. TNF-α ... «Nature.com, Jul 15»
6
New Insights Suggest Thiocyanate Could Address Lung …
Cystic fibrosis (CF) is a pleiotropic disease, which means that a gene mutation influences more than one bodily system. CF occurs when there ... «Cystic Fibrosis News Today, Jul 15»
7
Gene therapy clinical trial underway for children's motor neuron …
GAN, like many single-gene diseases, is "pleiotropic" – it has several signs and symptoms. When patients present with different subsets of the ... «Medical Xpress, Jul 15»
8
Gene Variant May Affect Postnatal Growth
... that IGF-II, which is a known insulin-like mediator of intrauterine development, may contribute to postnatal growth and has pleiotropic effects. «MedPage Today, Jul 15»
9
PCSK9 Inhibitors vs. The Guidelines
... was better for cardiovascular risk reduction whatever the means used to get it there, rather than being a special pleiotropic benefit of statins. «MedPage Today, Jul 15»
10
The Pleiotropic Art of Medicine
The practice of medicine is complex. It's an art. Art can benefit from the adoption of new technology, growing in its robustness and expression. «Medscape, Jul 15»

REFERENCE
« EDUCALINGO. Pleiotropic [online]. Available <https://educalingo.com/en/dic-en/pleiotropic>. Dec 2019 ».
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