Meaning of "tamoxifen" in the English dictionary

ETYMOLOGY OF THE WORD TAMOXIFEN

Altered from t(rans-) + am(ine) + oxy-² + phen(ol).

Etymology is the study of the origin of words and their changes in structure and significance.

PRONUNCIATION OF TAMOXIFEN

tamoxifen  [təˈmɒksɪfɛn]

GRAMMATICAL CATEGORY OF TAMOXIFEN

Tamoxifen is a noun.

A noun is a type of word the meaning of which determines reality. Nouns provide the names for all things: people, objects, sensations, feelings, etc.

WHAT DOES TAMOXIFEN MEAN IN ENGLISH?

Tamoxifen

Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked. Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries and is sold under the trade names Nolvadex, Istubal, and Valodex.

Definition of tamoxifen in the English dictionary

The definition of tamoxifen in the dictionary is a drug that antagonizes the action of oestrogen and is used to treat breast cancer and some types of infertility in women.

TRANSLATION OF TAMOXIFEN

Find out the translation of tamoxifen to 25 languages with our English multilingual translator.

The translations of tamoxifen from English to other languages presented in this section have been obtained through automatic statistical translation; where the essential translation unit is the word «tamoxifen» in English.

• Translator English - Chinese: 他莫昔芬
• Translator English - Spanish: tamoxifeno
• English: tamoxifen
• Translator English - Hindi: tamoxifen
• Translator English - Arabic: تاموكسيفين
• Translator English - Russian: тамоксифен
• Translator English - Portuguese: tamoxifeno
• Translator English - Bengali: tamoxifen
• Translator English - French: tamoxifène
• Translator English - Malay: Tamoxifen
• Translator English - German: Tamoxifen
• Translator English - Japanese: タモキシフェン
• Translator English - Korean: 타목시펜 (tamoxifen)
• Translator English - Javanese: Tamoxifen
• Translator English - Vietnamese: tamoxifen
• Translator English - Tamil: தமொக்சிபேன்
• Translator English - Marathi: टॅमॉक्सीफाइन
• Translator English - Turkish: tamoksifen
• Translator English - Italian: tamoxifene
• Translator English - Polish: tamoksyfen
• Translator English - Ukrainian: тамоксифен
• Translator English - Romanian: tamoxifen
• Translator English - Greek: ταμοξιφαίνη
• Translator English - Afrikaans: tamoxifen
• Translator English - Swedish: tamoxifen
• Translator English - Norwegian: tamoxifen

10 ENGLISH BOOKS RELATING TO «TAMOXIFEN»

Discover the use of tamoxifen in the following bibliographical selection. Books relating to tamoxifen and brief extracts from same to provide context of its use in English literature.

Tamoxifen

In this regard, the volume contributes important information to help readers weigh the costs and benefits of the treatment. Annotation copyright by Book News, Inc., Portland, OR

John A. Kellen, 1996

Long-term Tamoxifen Treatment for Breast Cancer

This volume provides invaluable information for physicians and surgeons who care for patients with breast cancer and for women interested in exploring this therapeutic dimension.

Virgil Craig Jordan, 1994

Tamoxifen: molecular basis of use in cancer treatment and ...

This book explains the molecular basis of the action of tamoxifen, knowledge of which is vital to the understanding of its present uses and future potential, particularly in relation to the development of new derivatives.

Helen Wiseman, 1994

Tamoxifen and Breast Cancer

"What everyone should know about the treatment of breast cancer"--Cover subtitle.

Michael W. DeGregorio, Valerie J. Wiebe, 1994

Advances in Tamoxifen Research and Application: 2011 ...

Advances in Tamoxifen Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Tamoxifen in a concise format.

‎2012

In re: tamoxifen-citrate antitrust litigation: Joblove, et ...

The case concerns a decision by a divided panel of the Appeals Court upholding the dismissal of an antitrust challenge to a patent litigation settlement between AstraZeneca, the manufacturer of tamoxifen citrate, the most widely prescribed ...

Betty Joblove, Mark A. Lemley, Barr Laboratories, 2005

Estradiol Effectively Inhibits the Growth of ...

Protein kinase C alpha (PKCalpha) overexpression in a hormone dependent breast cancer cell line T47D:A18 results in autonomous growth and tamoxifen (TAM) resistance both in vitro and in vivo.

Yiyun Zhang, 2008

Notch Signaling in Protein Kinase C Alpha Overexpressing, ...

Notch signaling controls cell fate decisions including during development and stem cells renewal and differentiation.

Jieun Yun, 2007

Tissue-specific in Vitro and in Vivo Evaluation of ...

Interestingly, historical studies have shown that mixed treatment of EE and TAM results in an inhibition of EE-mediated uterotrophy.

Cora Jung-Yee Fong, 2007

Tamoxifen: Pioneering Medicine in Breast Cancer

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor.

Philipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan, 2013

10 NEWS ITEMS WHICH INCLUDE THE TERM «TAMOXIFEN»

Find out what the national and international press are talking about and how the term tamoxifen is used in the context of the following news items.

Breast Cancer Survival Improved With Arimidex

After an average follow-up period of 8.6 years, 114 breast cancers were detected in the tamoxifen group compared to 84 in the anastrozole group, the group ... «MedPage Today, Jun 15»

Anastrozole Shows Preventive Advantages Over Tamoxifen After DCIS

The first study to compare the efficacy and safety of tamoxifen versus anastrozole in women treated for ductal carcinoma in situ (DCIS) suggests that anastrozole ... «OncLive, May 15»

Coffee could make breast cancer drug tamoxifen more effective

"A cancer-killing cocktail of the hormone drug tamoxifen and two coffees every day was found to reduce the risk of [breast cancer] tumours returning," the Mail ... «NHS Choices, Apr 15»

Preventive Tamoxifen Lowers Rate of ER-Positive Breast Cancer

Tamoxifen given to women at high risk for breast cancer significantly lowered the rate of breast cancer diagnosis in the International Breast Cancer Intervention ... «Cancer Network, Dec 14»

Tamoxifen As A Breast Cancer Preventive -- Mixed Results In Long …

Yesterday researchers updated long-term findings of a large, randomized trial evaluating tamoxifen in its capacity and safety as a breast cancer preventive. «Forbes, Dec 14»

Breast Cancer: Tamoxifen Benefit Durable

SAN ANTONIO -- Tamoxifen's primary prevention benefits continue to accrue long-term, reaching a number needed to treat of just 22 at 2 decades of follow-up in ... «MedPage Today, Dec 14»

Night light exposure could make breast cancer tumors tamoxifen …

Tamoxifen is an estrogen-blocking medication typically used to treat breast cancer that has spread to other parts of the body. But new research conducted in rats ... «Medical News Today, Jul 14»

Gel tamoxifen effective for breast cancer, fewer side effects than oral …

Tamoxifen is a hormone drug that binds to estrogen receptors, blocking its actions so that cells - including cancer cells - needing estrogen to divide, stop growing ... «Medical News Today, Jul 14»

Tamoxifen for 10 Years an Option: ASCO Guideline Update

Women with stage I to III hormone receptor–positive breast cancer should consider taking tamoxifen for 10 years, the American Society of Clinical Oncology ... «Medscape, May 14»

Nick Calathes suspended 20 games, tested postive for breast …

Sports' Adrian Wojnarowski reported the news and says Calathes tested positive for Tamoxifen, which was part of an over-the-counter supplement he was taking ... «Larry Brown Sports, Apr 14»