10 ENGLISH BOOKS RELATING TO «THIOTEPA»
Discover the use of
thiotepa in the following bibliographical selection. Books relating to
thiotepa and brief extracts from same to provide context of its use in English literature.
1
Blood and Marrow Stem Cell Transplantation: Principles, ...
Therapeutic Use Initially, thiotepa was noted to have activity against a variety of
malignancies including breast, ovarian, Hodgkin's disease, and leukemia (Dorr
and Von Hoff, 1994). Modest anti- tumor activity has also been demonstrated with
...
Marie Bakitas Whedon, Debra Wujcik, 1997
2
Adult and Pediatric Urology
Lamm and colleagues (1 90) reviewed nine controlled studies, which included 1,
1 30 patients treated with thiotepa for prophylaxis, and combined these data to
determine the long-term ability of intravesical thiotepa to reduce recurrences.
Jay Young Gillenwater, 2002
3
Thomas' Hematopoietic Cell Transplantation
The cellular pharmacology of thiotepa, which is highly lipid soluble, is
characterized by an initial, rapid diffusion-mediated uptake into tumor cells [200]
followed by irreversible binding to intracellular macromolecules. A secondary,
much slower, ...
Frederick R. Appelbaum, Stephen J. Forman, Robert S. Negrin, 2011
Chemotherapy Thiotepa The nitrogen mustard analog thiotepa, or triethylene-
thiophosphoramide, has been advocated as an adjunctive measure to reduce the
postoperative recurrence of pterygium since 1962.80 Thiotepa is an alkylating ...
Jay H. Krachmer, Mark J. Mannis, Edward J. Holland, 2005
5
The Guide to Off-label Prescription Drugs: New Uses for ...
(thye-oh-TEP-a) Brand: Thioplex Thiotepa is in a class of drugs called cytotoxic
drugs typically used to treat cancer because they slow or stop the growth of
rapidly dividing cells,such as cancer cells. American Journal of Ophthalmology ...
Kevin R. Loughlin, Joyce A. Generali, 2006
6
Eighth Annual Report on Carcinogens: 1998 Summary
those undergoing surgery alone, and in some of these patients, thiotepa was the
only chemotherapeutic agent given (reviewed in IARCV.50, 1990). Thiotepa is
carcinogenic at multiple sites in both sexes of mice and rats. In mice, thiotepa ...
7
Report on Carcinogens (12th Ed. )
Thiotepa is known to be a human carcinogen based on sufficient ev- idence from
studies in humans. Thiotepa was first listed in the Second Annual Report on
Carcinogens in 1981 as reasonably anticipated to be a human carcinogen based
on ...
Nat. Toxicology Program (NTP) (NIH), 2011
8
Textbook of Breast Cancer: A Clinical Guide to Therapy
HD better, p= 0.02a No difference, HD less relapses No difference, HD less
relapses HD better, p= 0.002 RFS analysis No difference 9 X FEC better 2 X EC +
2 X EC-Thiotepa HD better, NS HD better, NS HD better HD better, NS No
difference ...
Gianni Bonadonna, Gabriel N. Hortobagyi, Pinuccia Valagussa, 2006
9
Index Nominum 2000: International Drug Directory
... US) (Schein: US) Thiotepa (Rec.INN) iiondazine Thioridazine Hydrochloride®
Thioridazine Hydrochloride® Thioridazine Hydrochloride® Thioridazine
Hydrochloride® Thioridazine Hydrochloride® Thioridazine Hydrochloride®
Thioridazine ...
10
The Chemotherapy Source Book
Drug class: Alkylating agent Mechanism of action: Thiotepa acts as a classic
alkylating agent, alkylating the N-7 position of guanine, forming crosslinks with
DNA, thereby inhibiting DNA synthesis and function. It is cell cycle-independent.
Michael Clinton Perry, 2008
10 NEWS ITEMS WHICH INCLUDE THE TERM «THIOTEPA»
Find out what the national and international press are talking about and how the term
thiotepa is used in the context of the following news items.
Effect of the order of TBI and cyclophosphamide administration on …
Patients who received conditioning agents such as cytarabine, thiotepa and etoposide in addition to CY and TBI and those subjected to ex vivo or in vivo T-cell ... «Nature.com, Jul 15»
Hikma receives approval for thiotepa injection in the US
Thiotepa is indicated for the palliation of a wide variety of neoplastic diseases, with the most consistent results seen in tumors related to adenocarcinoma of the ... «PharmiWeb.com, Jul 15»
BRIEF-Hikma Pharma receives approval for thiotepa injection in US
Thiotepa is currently on FDA's drug shortages list and Hikma has only approved active US ANDA Source text (bit.ly/1HtOToy) Further company coverage: ... «Reuters, Jul 15»
Neoadjuvant chemotherapy demonstrates favorable outcomes in …
... or without second-look surgery went on to receive high-dose chemotherapy with thiotepa and etoposide and autologous peripheral blood stem cell rescue. «Healio, Jul 15»
Adding Rituximab and Thiotepa to Chemo Doublet Improves …
The MATRIX regimen, comprised of a methotrexate/cytarabine backbone plus thiotepa and rituximab, improved outcomes in patients with primary CNS ... «OncLive, Jun 15»
CME - Frequently Asked Questions in Improving Detection and Initial …
Thiotepa (triethylenethiophosphoramide) is an alkylating agent. Introduced in 1961, thiotepa is the oldest and one of the least expensive of the intravesical ... «UroToday, Oct 14»
Salem man fights cancer a second time with help
Next week Yunker will get tested to see whether he's a good candidate for treatment that includes Thiotepa, a chemotherapy drug in short supply. His dad said it ... «Statesman Journal, Oct 14»
Parents of boy who died from effects of cancer treatment call for …
But he was then put on a further chemotherapy course with a drug called Thiotepa in accordance with the Milan protocol – a regime that had been reported to ... «The Guardian, Sep 14»
High-Dose Chemo Before RT Results in High Survival in Pediatric …
After biopsy or initial surgery patients received postoperative induction chemotherapy two cycles of etoposide/carboplatin, followed by two courses of thiotepa ... «Cancer Network, Jun 14»
Drug Shortages: New Ones Down, Old Ones Persist
She said multiple shortages -- cancer drug thiotepa (Tepadina), ethiodized oil (Ethiodol), and trace element products -- rely on imported drugs when ... «MedPage Today, Aug 13»
