10 ENGLISH BOOKS RELATING TO «TOPOISOMERASE»
Discover the use of
topoisomerase in the following bibliographical selection. Books relating to
topoisomerase and brief extracts from same to provide context of its use in English literature.
1
DNA
Topoisomerase Protocols
The method of the unwinding test utilizing plasmid DNA and an eukaryotic type I
DNA topoisomerase has been described by Pommier et al. (5). As illustrated in
Fig. 1, a native supercoiled or relaxed plasmid DNA is first incubated with the test
...
Neil Osheroff, Mary-Ann Bjornsti, 2001
2
DNA Topoisomerases in Cancer Therapy: Present and Future
This volume commemorates the 30th anniversary of the discovery in 1971 of the first DNA topoisomerases, i.e topoisomerase I in E. coli, then provisionally named `omega' protein, by the pioneering work of Jim Wang at Harvard University, who ...
3
A Role for Drosophila
Topoisomerase IIIalpha in the ...
Topoisomerase IIIalpha (Togo IIIalpha), a type IA topoisomerase, has been shown to be essential in mice, although its role in DNA metabolism remains to be elucidated.
4
DNA Topoisomearases: Biochemistry and Molecular Biology: ...
argue strongly that an essential function of topoisomerase IV is in the segregation
of replicated bacterial DNA molecules. Similarly, experiments by Peng and
Marians (1993), using in vitro replication systems for oriC or pBR322, also argue
that ...
5
CDC45 Function Alters Cell Sensitivity to DNA
Topoisomerase ...
The cdc45-10 defects in origin firing and replication fork progression were characterized by isolating replication intermediates and resolving them using 2-D gel electrophoresis.
Cynthia Sue Lancaster, 2008
6
Current Pharmaceutical Design
Type I Enzymes Eukaryotic DNA topoisomerase I is an ubiquitous and abundant
nuclear enzyme that is commonly isolated as a 67-kDa or a 100-kDa monomeric
protein [4,5,26-28]. The lower- molecular-weight enzyme is believed to be a ...
7
Chemical Approaches Towards Capturing and Imaging a ...
Type IIA topoisomerases are essential enzymes necessary for resolving topological problems that arise during the transcription and replication of DNA.
8
Breast Cancer Chemosensitivity
Recent results indicated that MRP1 and MRP2 are also able to confer resistance
to the polyglutamatable antifolate methotrexate (MTX).54 MDR Associated with
Topoisomerase Poisons Topoisomerases are nuclear enzymes that catalyze the
...
Dihua Yu, Mien-Chie Hung, 2009
9
Drug Resistance to
Topoisomerase Directed Chemotherapy in ...
In this dissertation we have shown that myeloma is intrinsically resistant to
commonly used topoisomerase inhibitors by microenvironmental factors that
induce nuclear export of topo IIα. In addition, during disease progression
myeloma ...
10
Drug Targets in Kinetoplastid Parasites
Type I DNA topoisomerases were isolated from L. donovani, Trypanosoma cruzr
and Crithidia fasciculated The purified active enzymes (65 - 79 kDa) were ATP-
independent and found to be sensitive to topoisomerase I specific inhibitor, ...
Hemanta K. Majumder, 2008
10 NEWS ITEMS WHICH INCLUDE THE TERM «TOPOISOMERASE»
Find out what the national and international press are talking about and how the term
topoisomerase is used in the context of the following news items.
Could autism and 'chemo brain' share similar origin?
Neurons expressing the Topoisomerase-1 gene (shown in green): It directs production of ... It inhibits the formation of an enzyme called topoisomerase, which is ... «Charlotte Observer, Feb 15»
IISc: Repurposing existing drugs to fight TB
The two small molecules work by targeting the Topoisomerase I enzyme of the TB ... But human Topoisomerase I enzyme has properties and functions that are ... «The Hindu, Jan 15»
Antibodies Predict Scleroderma Renal Crisis
Several types of these antibodies are SSc-specific, including antibodies against centromeres, topoisomerase I, and RNAP III. "Importantly, antinuclear antibodies ... «MedPage Today, Dec 14»
Biomarker-Driven Trial of Novel Topo-1 Inhibitor Debuted
An international team of investigators is evaluating the novel topoisomerase-1 inhibitor etirinotecan pegol in patients with metastatic breast cancer, and at the ... «Targeted Oncology, Dec 14»
Researchers pinpoint chemo effect on brain cells, potential link to …
In the PNAS paper, the researchers describe how topotecan hits its intended target - the topoisomerase proteins that are integral for cell division, a hallmark of ... «Medical Xpress, Dec 14»
TopBP1 a sweet spot for treatment in multiple cancers
A compound called calcein may act to inhibit topoisomerase IIβ-binding protein 1 (TopBP1), which enhances the growth of tumors, said researchers from Baylor ... «Baylor College of Medicine News, Nov 14»
Team identifies 'molecular scissors' required for successful …
Now, Hughes and R. Scott Hawley, Ph.D., have shown that an enzyme called Topoisomerase II is required for resolving these threads so homologous ... «Phys.Org, Oct 14»
Joints Tell the Future in Scleroderma
Be aware that anti-topoisomerase antibodies also performed well prognostically. Easily assessed clinical signs of joint and tendon involvement early in the ... «MedPage Today, Oct 14»
Determination of Disk Diffusion and MIC Quality Control Guidelines …
GSK2140944 is a novel bacterial type II topoisomerase inhibitor in development for the treatment of conventional and biothreat pathogens, including ... «Journal of Clinical Microbiology, Jun 14»
Untying DNA knots
They have revealed how one unit of the machine, RMI, modulates the workings of an enzyme, topoisomerase IIIα (TopIIIα), thus allowing double Holliday ... «Phys.Org, Feb 14»
