KSIĄŻKI POWIĄZANE ZE SŁOWEM «UPAR»
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1
PNH and the GPI-Linked Proteins - Halaman 108
The role of the urokinase activator receptor (uPAR), a GPI-linked protein, in cell-mediated fibrinolysis has not been substantially investigated and its clinical significance remains in doubt [27, 28]. uPAR serves as a receptor for the inactive ...
Neal S. Young, Joel Moss,
2000
2
Guidebook to the Extracellular Matrix, Anchor, and ... - Halaman 559
The N-terminal growth factor-like domain of uPA has been shown to bind uPA to uPAR. lndeed, the liberated uPA growth factor domain itself and chimeric proteins containing this domain are able to bind uPAR and compete with uPA for cell ...
Thomas Kreis, Ronald Vale,
1999
3
Breast Cancer Advances in Biology and Therapeutics - Halaman 203
All extracts contained measurable amounts of uPAR. Buffer C was the most efficient for extraction of uPAR while buffer B extracted 51% and buffer A 28% of the amount extracted by buffer C. We also studied uPAR in a set of 94 breast tumor ...
Fabien Calvo, Henri Magdelenat,
1996
4
Textbook of Pulmonary Vascular Disease - Halaman 417
Initial studies of the uPAR-deficient mouse failed to identify a significant role of the receptor in fibrinolysis as well as a number of other models [119, 120], but subsequent studies have implicated uPAR in inflammatory cell recruitment in certain ...
Jason X. -J. Yuan, Joe G.N. Garcia, Charles A. Hales,
2011
5
Apoptosis, Cell Signaling, and Human Diseases: Molecular ...
Downregulation of uPAR induces dormancy (44); lack of cellular proliferation by reversing Erk signaling. Higher uPAR expression and its interaction with active 51 integrin is required for phosphorylation of FAK and Src in tumor cells (11).
6
Soluble Factors Mediating Innate Immune Responses to ...
The activity of uPA is regulated by uPAR, plasmin, PAIs and by endocytosis. uPAR is the cellular receptor for uPA [42]. It is a 55-60 kDa single-chain highly glycosylated protein consisting of three homologous domains (uPAR(I), uPAR(II) and ...
7
Brain Tumors - Halaman 237
UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR The receptor for the urokinase-type plasminogen activator (uPAR), also called CD87, is related to members of the human CD59 and the mouse Ly-6 family (89). The uPAR gene ...
8
Matrix Proteases in Health and Disease - Halaman 326
Niels Behrendt. II II II II II II II III III III III III III III I I I II III I II III I I I I uPA uPA uPA P A I-1 uPA uPA Nucleus uPAR Figure 13.1 uPAR, consisting of three structurally homologous domains (I, II, and III), is a cell surface protein anchored to the cell ...
9
Hemostasis and Thrombosis: Basic Principles and Clinical ...
In contrast, an immunochemical study on l.ewis lung carcinoma transplanted in mice showed PAI-1 protein in the tumor cells themselves (149). l.ike PAI-1, uPA and its receptor, uPAR, have also been correlated with a poor prognosis in cancer ...
10
Angiogenesis, Lymphangiogenesis and Clinical Implications:
uPAR forms are unable to bind both uPA and VN, suggesting the cleavage of cellmembrane uPAR as a regulatory mechanism to abolish uPAR activities at the cell surface, i.e. focused proteolysis and binding to the ECM [5]. However, the ...
G. Marone, F. Granata,
2013