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azathioprine

Meaning of "azathioprine" in the English dictionary

DICTIONARY

ETYMOLOGY OF THE WORD AZATHIOPRINE

From aza- + thio- + p(u)rine.

Etymology is the study of the origin of words and their changes in structure and significance.

PRONUNCIATION OF AZATHIOPRINE

ˌæzəˈθaɪəˌpriːn


GRAMMATICAL CATEGORY OF AZATHIOPRINE

noun
adjective
verb
adverb
pronoun
preposition
conjunction
determiner
exclamation
Azathioprine is a noun.
A noun is a type of word the meaning of which determines reality. Nouns provide the names for all things: people, objects, sensations, feelings, etc.

WHAT DOES AZATHIOPRINE MEAN IN ENGLISH?

Azathioprine

Azathioprine is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues. Synthesized originally as a cancer drug and a prodrug for mercaptopurine in 1957, it has been widely used as an immunosuppressant for more than 50 years. Azathioprine acts as a prodrug for mercaptopurine, inhibiting an enzyme that is required for the synthesis of DNA. Thus it most strongly affects proliferating cells, such as the T cells and B cells of the immune system. The main adverse effect of azathioprine is bone marrow suppression, which can be life-threatening, especially in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. It is also listed by the International Agency for Research on Cancer as a Group 1 carcinogen. Azathioprine is produced by a number of manufacturers under different brand names. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Definition of azathioprine in the English dictionary

The definition of azathioprine in the dictionary is a synthetic drug that suppresses the normal immune responses of the body and is administered orally during and after organ transplantation and also in certain types of autoimmune disease. Formula: C9H7N7O2S.

WORDS THAT RHYME WITH AZATHIOPRINE

Adiprene · chloroprene · evergreen · figurine · green · Greene · isoprene · isoxsuprine · marine · neoprene · on-screen · outpreen · polychloroprene · polyisoprene · preen · screen · submarine · vitrine · widescreen · wolverine

WORDS THAT BEGIN LIKE AZATHIOPRINE

az · az. · azalea · azan · Azania · Azanian · AZAPO · Azazel · Azbine · azedarach · azeotrope · azeotropic · azeotropy · Azerbaijan · Azerbaijani · Azeri · AZERTY · azerty keyboard · azide · azido

WORDS THAT END LIKE AZATHIOPRINE

aquamarine · brine · caprine · Catherine · chlorine · cyprine · doctrine · endocrine · exocrine · Katharine · Katherine · margarine · murine · poitrine · serine · shrine · tangerine · trine · urine · uterine

Synonyms and antonyms of azathioprine in the English dictionary of synonyms

SYNONYMS

Translation of «azathioprine» into 25 languages

TRANSLATOR

TRANSLATION OF AZATHIOPRINE

Find out the translation of azathioprine to 25 languages with our English multilingual translator.

The translations of azathioprine from English to other languages presented in this section have been obtained through automatic statistical translation; where the essential translation unit is the word «azathioprine» in English.
zh

Translator English - Chinese

硫唑嘌呤
1,325 millions of speakers
es

Translator English - Spanish

azatioprina
570 millions of speakers
en

English

azathioprine
510 millions of speakers
hi

Translator English - Hindi

azathioprine
380 millions of speakers
ar

Translator English - Arabic

الآزوثيوبرين
280 millions of speakers
ru

Translator English - Russian

азатиоприн
278 millions of speakers
pt

Translator English - Portuguese

azatioprina
270 millions of speakers
bn

Translator English - Bengali

azathioprine
260 millions of speakers
fr

Translator English - French

azathioprine
220 millions of speakers
ms

Translator English - Malay

Azathioprine
190 millions of speakers
de

Translator English - German

Azathioprin
180 millions of speakers
ja

Translator English - Japanese

アザチオプリン
130 millions of speakers
ko

Translator English - Korean

아자 티오 프린
85 millions of speakers
jv

Translator English - Javanese

Azathioprine
85 millions of speakers
vi

Translator English - Vietnamese

azathioprine
80 millions of speakers
ta

Translator English - Tamil

அசாதியோப்ரின்
75 millions of speakers
mr

Translator English - Marathi

अझॅथीओप्रिन
75 millions of speakers
tr

Translator English - Turkish

azatioprin
70 millions of speakers
it

Translator English - Italian

azatioprina
65 millions of speakers
pl

Translator English - Polish

azatiopryna
50 millions of speakers
uk

Translator English - Ukrainian

азатіоприн
40 millions of speakers
ro

Translator English - Romanian

azatioprina
30 millions of speakers
el

Translator English - Greek

αζαθειοπρίνη
15 millions of speakers
af

Translator English - Afrikaans

azathioprine
14 millions of speakers
sv

Translator English - Swedish

azatioprin
10 millions of speakers
no

Translator English - Norwegian

azatioprin
5 millions of speakers

Trends of use of azathioprine

TRENDS

TENDENCIES OF USE OF THE TERM «AZATHIOPRINE»

Principal search tendencies and common uses of azathioprine
List of principal searches undertaken by users to access our English online dictionary and most widely used expressions with the word «azathioprine».

Examples of use in the English literature, quotes and news about azathioprine

EXAMPLES

10 ENGLISH BOOKS RELATING TO «AZATHIOPRINE»

Discover the use of azathioprine in the following bibliographical selection. Books relating to azathioprine and brief extracts from same to provide context of its use in English literature.
1
Current Therapy in Neurologic Disease
Because the beneficial effects of azathioprine may take more than 6 months to appear, the combination of azathioprine and steroids or azathioprine and IVIg affords the relatively rapid onset of immunosuppression produced by the steroids or ...
Richard Tidball Johnson, John W. Griffin, Justin C. McArthur, 2006
2
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal ...
Intrauterine growth restriction also has been reported, but this effect may have been a consequence of multiple factors, one of which was azathioprine, working in combination. Taken in sum, however, the evidence suggests that the maternal  ...
Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe, 2011
3
Chemical Stability of Pharmaceuticals: A Handbook for ...
4. cx>. C9H7N702S mol. wt . 277.3 Forms Available Free acid ( az a t h 1 o pr i ne ) ; sodium a z a t h i op r i ne , Na( C9H6N702S) . Physical Properties Azathioprine melts at approximately 240°C (1). Solubility: 0.130 mg/mL in water at 25°C (2) ...
Kenneth Antonio Connors, 1986
4
Pediatric Gastrointestinal Disease: Pathophysiology, ...
or colonic resection.162 Another study suggested that aza- thioprine heals recurrent ileitis developing in the neoter- minal ileum.163 Azathioprine also has been widely used in the therapy of inflammatory bowel disease. The results suggest ...
W. Allan Walker, 2004
5
Advanced Therapy of Inflammatory Bowel Disease: Ulcerative ...
CONCLUSION In summary, the immunomodulators 6-MP and azathioprine are some of the best therapies currently available for the treatment of chronic UC. They are usually well tolerated and easy to dose. Unfortunately, many clinicians ...
Theodore M. Bayless, Stephen B. Hanauer, 2011
6
Textbook of Atopic Dermatitis
o Subjects receiving azathioprine 2.5 mg/kg/day (n = 18) followed by placebo (n = 1 1 ) 0 Subjects receiving placebo (n = 17) followed by azathioprine (n = 15) Figure 18.4 Mean SASSAD scores during treatment for 3 months with azathioprine ...
Sakari Reitamo, Thomas A. Luger, Martin Steinhoff, 2008
7
A Manual of Adverse Drug Interactions
In the treatment of psoriatic arthritis there is the clinical belief that azathioprine is more effective for the arthritic element and methotrexate for the dermatological manifestations. In myasthenia gravis where thymectomy is not advisable ...
J.P. Griffin, P.F. D'Arcy, 1997
8
European Drug Index: European Drug Registrations, Fourth Edition
Azathioprinum 50mg (L04AX01) (BG) Azathioprine (Generics) tab.: Azathioprinum 50mg(L04AX01)(BG) Azathioprinetablets 50 mg Azathioprine ( L04AX01)(RUS) Azathioprine 50mg(Medexport V/O Moscow) tab.: Azathioprinum (L04AX01) ...
Muller, 1998
9
Kidney Transplantation - Principles and Practice
Azathioprine and 6-mercaptopurine are thiopurines, and azathioprine is an imidazolyl derivative of 6-mercaptopurine. Azathioprine is metabolized in the liver before becom- ing active. One metabolic pathway is through its con- version to ...
Peter Morris, Stuart J. Knechtle, 2013
10
Concepts in Immunology and Immunotherapeutics
The therapeutic use of azathioprine in renal transplantation. Pharmacotherapy. 1987; 7(5):165–177. 96. Van Scoik KG, Johnson CA, Porter WR. The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine.
Blaine T. Smith, 2008

10 NEWS ITEMS WHICH INCLUDE THE TERM «AZATHIOPRINE»

Find out what the national and international press are talking about and how the term azathioprine is used in the context of the following news items.
1
Kansas senior's battle with rare disease and how to help. What is …
Immunosuppressant drugs, such as azathioprine and methotrexate, may reduce inflammation in people who do not respond well to prednisone ... «Outbreak News Today, Jul 15»
2
SIMPONI® Receives European Commission Approval for Treatment …
... including corticosteroids and 6-mercaptopurine or azathioprine, or who are intolerant to or have medical contraindications for such therapies. «PharmiWeb.com, Jul 15»
3
Pfizer Announces FDA Acceptance for Review of New Drug …
Use of XELJANZ in combination with biologic DMARDs or potent immunosuppressants, such as azathioprine and cyclosporine is not ... «MarketWatch, Jul 15»
4
Necrotizing Myopathy: Are Statins to Blame?
Treatment of these patients has included prednisone, azathioprine, methotrexate, rituximab, and intravenous immunoglobulin (IVIG). «MedPage Today, Jul 15»
5
Psoriatic Arthritis Pharmacotherapy Market Segment Forecasts up to …
While immunosuppressant helps to control the immune system including azathioprine and cyclosporine. TNF-α inhibitors assist reducing pain, ... «CSO Australia, Jul 15»
6
As PGx Program Grows, Vanderbilt Hoping to Expand Reported …
... at Vanderbilt have TPMT alleles that placed them at risk for responding poorly to thiopurines — drugs such as azathioprine, mercaptopurine, ... «GenomeWeb, Jun 15»
7
mTOR inhibitor versus mycophenolic acid as the primary …
Since mycophenolic acid (MPA) was introduced into solid organ transplantation, it has largely replaced azathioprine (AZA) as the ... «BMC Blogs Network, Jun 15»
8
EU approves Simponi to treat non-radiographic axial spondyloarthritis
... including corticosteroids and 6-mercaptopurine or azathioprine, or who are intolerant to or have medical contraindications for such therapies. «pharmabiz.com, Jun 15»
9
Infections, age and medications linked to death in patients with …
... followed by intravenous glucocorticoids in 64%, cyclophosphamide in 43%, pulse cyclophosphamide in 49% and azathioprine in 25%. «Healio, Jun 15»
10
Early treatment best for rheumatoid arthritis
Commonly prescribed DMARDs include methotrexate, sulfasalazine, penicillamine, leflunomide, azathioprine, cyclosporin and mycophenolate. «Stuff.co.nz, Jun 15»
REFERENCE
« EDUCALINGO. Azathioprine [online]. Available <https://educalingo.com/en/dic-en/azathioprine>. Apr 2024 ».
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