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Meaning of "phenformin" in the English dictionary

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DICTIONARY
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ETYMOLOGY OF THE WORD PHENFORMIN

From phen(yl) + form(aldehyde) +-in.
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Etymology is the study of the origin of words and their changes in structure and significance.
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PRONUNCIATION OF PHENFORMIN

phenformin  [fɛnˈfɔːmɪn] play
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GRAMMATICAL CATEGORY OF PHENFORMIN

noun
adjective
verb
adverb
pronoun
preposition
conjunction
determiner
exclamation
Phenformin is a noun.
A noun is a type of word the meaning of which determines reality. Nouns provide the names for all things: people, objects, sensations, feelings, etc.

WHAT DOES PHENFORMIN MEAN IN ENGLISH?

Phenformin

Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was discovered in 1957 by Ungar, Freedman and Seymour Shapiro, working for the US Vitamin Corporation. Clinical trials begun in 1958 showed it to be effective, but with gastrointestinal side effects.

Definition of phenformin in the English dictionary

The definition of phenformin in the dictionary is a biguanide administered orally in the treatment of diabetes to lower blood concentrations of glucose; it has been largely superseded by metformin. Formula: C10H15N5.

WORDS THAT RHYME WITH PHENFORMIN


adermin
əˈdɜːmɪn
Brahmin
ˈbrɑːmɪn
determine
dɪˈtɜːmɪn
dormin
ˈdɔːmɪn
Emin
ˈiːmɪn
enlumine
ɛnˈljuːmɪn
ermine
ˈɜːmɪn
extermine
ɪkˈstɜːmɪn
haemin
ˈhiːmɪn
hemin
ˈhiːmɪn
illumine
ɪˈluːmɪn
legumin
lɪˈɡjuːmɪn
lumen
ˈluːmɪn
lumine
ˈluːmɪn
metformin
metˈfɔːmɪn
predetermine
ˌpriːdɪˈtɜːmɪn
redetermine
ˌriːdɪˈtɜːmɪn
reillumine
ˌriːɪˈluːmɪn
toxalbumin
ˌtɒksælˈbjuːmɪn
vermin
ˈvɜːmɪn

WORDS THAT BEGIN LIKE PHENFORMIN

phenarsazine chloride
phenate
phenazine
phencyclidine
phene
phenetic
pheneticist
phenetics
phenetidine
phenetole
phengite
phengophobia
phenic
phenix
phenmetrazine
phenobarbital
phenobarbitone
phenocopies
phenocopy
phenocryst

WORDS THAT END LIKE PHENFORMIN

admin
albumin
Amin
benjamin
cobalamin
cosmin
cumin
gamin
Jiang Zemin
maximin
min
multivitamin
provitamin
ramin
saimin
serum albumin
sysadmin
theremin
thiamin
vitamin

Synonyms and antonyms of phenformin in the English dictionary of synonyms

SYNONYMS

Translation of «phenformin» into 25 languages

TRANSLATOR
online translator

TRANSLATION OF PHENFORMIN

Find out the translation of phenformin to 25 languages with our English multilingual translator.
The translations of phenformin from English to other languages presented in this section have been obtained through automatic statistical translation; where the essential translation unit is the word «phenformin» in English.

Translator English - Chinese

苯乙双胍
1,325 millions of speakers

Translator English - Spanish

fenformina
570 millions of speakers

English

phenformin
510 millions of speakers

Translator English - Hindi

phenformin
380 millions of speakers
ar

Translator English - Arabic

فينفورمين
280 millions of speakers

Translator English - Russian

фенформин
278 millions of speakers

Translator English - Portuguese

fenformina
270 millions of speakers

Translator English - Bengali

phenformin
260 millions of speakers

Translator English - French

phenformin
220 millions of speakers

Translator English - Malay

Phenformin
190 millions of speakers

Translator English - German

Phenformin
180 millions of speakers

Translator English - Japanese

フェンホルミン
130 millions of speakers

Translator English - Korean

펜 포르 민
85 millions of speakers

Translator English - Javanese

Phenformin
85 millions of speakers
vi

Translator English - Vietnamese

phenformin
80 millions of speakers

Translator English - Tamil

phenformin
75 millions of speakers

Translator English - Marathi

Phenformin
75 millions of speakers

Translator English - Turkish

fenforminin
70 millions of speakers

Translator English - Italian

fenformina
65 millions of speakers

Translator English - Polish

fenformina
50 millions of speakers

Translator English - Ukrainian

фенформин
40 millions of speakers

Translator English - Romanian

phenformin
30 millions of speakers
el

Translator English - Greek

phenformin
15 millions of speakers
af

Translator English - Afrikaans

phenformin
14 millions of speakers
sv

Translator English - Swedish

fenformin
10 millions of speakers
no

Translator English - Norwegian

phenformin
5 millions of speakers

Trends of use of phenformin

TRENDS

TENDENCIES OF USE OF THE TERM «PHENFORMIN»

The term «phenformin» is normally little used and occupies the 143.250 position in our list of most widely used terms in the English dictionary.
0
100%
FREQUENCY
Little used
33
/100
The map shown above gives the frequency of use of the term «phenformin» in the different countries.
Principal search tendencies and common uses of phenformin
List of principal searches undertaken by users to access our English online dictionary and most widely used expressions with the word «phenformin».

FREQUENCY OF USE OF THE TERM «PHENFORMIN» OVER TIME

The graph expresses the annual evolution of the frequency of use of the word «phenformin» during the past 500 years. Its implementation is based on analysing how often the term «phenformin» appears in digitalised printed sources in English between the year 1500 and the present day.

Examples of use in the English literature, quotes and news about phenformin

EXAMPLES

10 ENGLISH BOOKS RELATING TO «PHENFORMIN»

Discover the use of phenformin in the following bibliographical selection. Books relating to phenformin and brief extracts from same to provide context of its use in English literature.
1
Endocrine Pharmacology: Physiological Basis and Therapeutic ...
Such a process is consistent with the occurrence of lactic acidosis, which in certain clinical circumstances may occur when phenformin is being used. c. It has also been suggested that these drugs produce a decline in gluconeogenesis from ...
P. J. Bentley, 1980
2
The Dictionary of Substances and Their Effects: O-S
phenformin. O". NH. NH. II. II. CH2CH2—. NH—. C—. NH—. C—. NH2. C10H15N5 Mol. Wt. 205.26 CAS Registry No. 114-86-3 Synonyms N-(2- phenylethyl)imidodicarbonimidic diamide; 1-phenethylbiguanide; Azucaps; fenformin; Glyphen; ...
S. Gangolli, Royal Society of Chemistry (Great Britain), 1999
3
Lewis' Dictionary of Toxicology
Upon decomposition by heating, it emits very toxic fumes (Cl" and NOX). phenestrin. fenesterine. phenethyl diguanide. phenformin. phenethylamine 03- phenethylamine; benzene- ethanamine; 0-phenylethylamine; 2- phenylethylamine; ...
Robert Alan Lewis, 1998
4
Frontiers in Neurodegenerative Disorders and Aging: ...
Vinnitski and lakumenko [135] have shown that treatment with phenformin increased the immunological reactivity and inhibited carcinogenesis induced by s.c. administration of 20- methylcholanthrene in BALB/c mice. 1n high fat-fed hamsters, ...
Tomris Özben, Mordechai Chevion, 2004
5
Clinical Drug Trials and Tribulations, Revised and Expanded, ...
Shortly afterwards, the labeling of phenformin was again changed in indicated that the drug should be considered only as a last resort when other oral agents were ineffective and insulin could not be used. This labeling change was a ...
Allen Cato, Lynda Sutton, Allen Cato III, 2002
6
Insulin Resistance and Cancer: Epidemiology, Cellular and ...
This notion is especially appealing since AMPK activators, such as metformin/ phenformin and TZDs, are already widely used for type 2 diabetes treatment and additional novel AMPK activators are being actively developed [15]. Indeed, in ...
I. George Fantus, 2011
7
ClinicalTrials: Design, Conduct and Analysis
The patient should be informed of the potential risks and This study providedno evidence that phenformin was more efficacious than diet alone or than diet and insulin in prolonging life for the patients studied. In fact, the observed mortality from ...
Curtis L. Meinert, 2012
8
Clinical Diabetes Mellitus: A Problem-oriented Approach
That phenformin was also associated with excess cardiovascular mortality in the UGDP study3 was hardly noticed; in fact, in this study, phenformin was also found to be associated with an increase in blood pressure, an observation that was ...
John K. Davidson, 2000
9
Consolidated List of Products Whose Consumption And/or Sale ...
BRA 14 Dec 1977 Combination products containing phenformin are prohibited. ( Reference: (BRAPT) Portaria do Servico Publico Federal, No.30, , Dec 1977) DNK 1978 Withdrawn following reports of occasional but sometimes fatal cases of ...
United Nations, 1983
10
PROGRESS IN MEDICINAL CHEMISTRY
Phenformin (/3-phenethylbiguanide, Dibotin) forms metal complexes with Cu and Ni, but not with Zn, Cd, Mg and the alkali earthsuzb. Assuming that chlorhexidine itself does not form a complex with Mg, then the observations that Mg++ ...
Gwynn Pennant Ellis, Geoffrey Buckle West, 2011

10 NEWS ITEMS WHICH INCLUDE THE TERM «PHENFORMIN»

Find out what the national and international press are talking about and how the term phenformin is used in the context of the following news items.
1
Discover China metformin market analysis and 2019 forecasts
However, influenced by the side effects of phenformin, metformin was once suggested to exit the market. Under the persistent exploration of ... «WhaTech, Jul 15»
2
Metformin induces ER stress-dependent apoptosis through miR-708 …
... Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates ... «Nature.com, Jun 15»
3
Landmarks in Diabetes: 1995 to 2015
... while the US Food and Drug Administration (FDA) focused on removing a related but more toxic compound, phenformin, from the market. «Medscape, May 15»
4
What's more scary? Diabetes drugs, not disease, says doctor
There was a more dangerous form of the drug called phenformin. But following widespread report of complications, it was withdrawn. CVK ... «Times of India, Apr 15»
5
Nano packages for anti-cancer drug delivery
Phenformin-loaded nanoparticles kill both cancer cells and cancer stem cells, leading to tumor regression. Credit: A*STAR Institute of ... «Phys.Org, Mar 15»
6
Niewydolność serca a cukrzyca
BMJ, 2007; 335: 497 43. Misbin R.I.: Phenformin-associated lactic acidosis: pathogenesis and treatment. Ann. Intern. Med., 1977; 87: 591–595 «Medycyna Praktyczna, Jan 15»
7
Metformin Label Too Restrictive on Renal Grounds, Limits Use
The rationale behind the current FDA label for metformin was established in 1994, when there was strong evidence that phenformin, another ... «Medscape, Jan 15»
8
Outdated Warning on Antidiabetic Drug Curtails Its Use
The agency based its safety recommendations on the experience of phenformin, a similar drug that was implicated in fatal cases of lactic ... «Cornell Chronicle, Jan 15»
9
Regulated vs unregulated
This is why the public will hear of some drugs, for example Vioxx, Propulsid, Fen-Phen, Phenformin, and Melleril, that were withdrawn from the ... «Jamaica Observer, Sep 14»
10
The Vicious Cycle of Dangerous Diabetes Drugs
Two drugs in this class, Phenformin and Buformin, have been withdrawn from the market due to their tendency to cause lactic acidosis – a ... «Injury Lawyer News, Jan 14»

REFERENCE
« EDUCALINGO. Phenformin [online]. Available <https://educalingo.com/en/dic-en/phenformin>. May 2024 ».
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