10 ENGLISH BOOKS RELATING TO «TACRINE»
Discover the use of
tacrine in the following bibliographical selection. Books relating to
tacrine and brief extracts from same to provide context of its use in English literature.
1
Design and Analysis of Clinical Trials: Concepts and ...
Table 5.5.3 Forced Dose-Escalation Design for 12-Week Trial of Tacrine in
Alzheimer's Disease Randomized Double-Blind Double-Blind Sequences Phase
I Weeks 1 to 6 Phase II Weeks 7 to 12 1 Placebo Placebo 2 Placebo Tacrine 20
mg/d ...
Shein-Chung Chow, Jen-Pei Liu, 2013
2
Lexicon of Psychiatry, Neurology, and the Neurosciences
tacrine + cimetidine tacrine/long-term follow-up with a modulating effect of
apparent volume of distribution. The authors of the study suggested that use of
tacrine for treatment of Alzheimer s disease will be confounded by high
interindividual ...
3
Psychiatric Side Effects of Prescription and ...
Patients with preexisting parkinsonism are likely at increased risk of worsening of
their disease when taking tacrine. Untreated tacrine-related encephalopathy has
been associated with lasting neuropsychiatric deficit (Trzepacz et al. 1996).
Thomas Markham Brown, Alan Stoudemire, 1998
4
Worst Pills, Best Pills: A Consumer's Guide to Preventing ...
ARICEPT (Pfizer) Tacrine (ta crin) COGNEX (Parke-Davis) FAMILY:
Cholinesterase Inhibitors Tacrine was the first drug approved by the FDA
exclusively for Alzheimer's disease, and donepezil the second. The action of both
drugs is to inhibit ...
5
The Practice of Medicinal Chemistry
The determination of the crystal structures of bis(5)tacrine and bis(7)-tacrine (
Figure 18.38) gave the structural basis for the observation that bis(7)-tacrine is an
optimal inhibitor (Torpedo californica IC50 1.5 nM).99 It forms favorable sandwich
...
Camille Georges Wermuth, 2011
6
CRC Desk Reference of Clinical Pharmacology
TACRINE HYDROCHLORIDE (Cognex) Tacrine (initially 10 mg p.o. q.i.d.) is
indicated in the treatment of mild to moderate dementia of the Alzheimer's type.
While many neuronal systems are affected in Alzheimer's disease. the decline in
...
7
Worst Pills, Best Pills: A Consumer's Guide to Avoiding ...
Donepezil (doe nepezil) ARICEPT (Pfizer) Tacrine (tacrin) COGNEX (Parke-
Davis) FAMILY: Cholinesterase Inhibitors Tacrine was the first drug approved by
the FDA exclusively for Alzheimer's disease, and donepezil the second. The
action of ...
8
Clinical Trial Methodology
Following the screening phase, patients who met entry criteria were randomized
in double-blind fashion to three possible sequences of treatment with tacrine
during the titration phase. Sequence I patients received 0 mg tacrine (placebo)
daily ...
Karl E. Peace, Ding-Geng (Din) Chen, 2010
9
Alzheimer's Disease: A Century of Scientific and Clinical ...
Of the ninety plus derivatives of monoamine acridine synthesized, Dr. Albert was
most intrigued by tacrine [1]. Tacrine is a planar three-ring acridine with minimal
substitution of an amino group in the five posi- tion (Fig. 1). Chemically tacrine ...
G. Perry, J. Avila, J. Kinoshita, 2006
10
Meyler's Side Effects of Psychiatric Drugs
Simon T, Becquemont L, Mary-Krause M, de Waziers I, Beaune P, Funck-
Brentano C, Jaillon P. Combined glutathione-S-transferase M1 and T1 genetic
polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther 2000;67(4):432–7
. 22.
10 NEWS ITEMS WHICH INCLUDE THE TERM «TACRINE»
Find out what the national and international press are talking about and how the term
tacrine is used in the context of the following news items.
Solanezumab Analysis Positive, But Clinical Benefits Unclear
Some studies of the acetylcholinesterase inhibitors donepezil (Aricept) and tacrine (Cognex) had used the design, which was developed by Paul Leber of FDA ... «MedPage Today, Jul 15»
Brief test can spot early stages of Alzheimer's
Those drugs are donepezil (Aricept), galantamine (Razadyne), memantine (Namenda), rivastigmine (Exelon) and tacrine (Cognex). So the search is on for tests ... «NWAOnline, Jul 15»
UNTHSC and CTT Researchers Test Novel Alzheimer's Drug
Donepezil, galantamine, memantine, rivastigmine and tacrine are the only drugs with an FDA approval so far. According to a press release, investigations ... «BioNews Texas, Apr 15»
Southern Illinois University researcher discusses Alzheimer's
... Seelbach said a variety of medications have been approved to slow the devastation, including donepezil, galantamine and tacrine. Seelbach noted, however ... «Effingham Daily News, Apr 15»
Acetylcholinesterase Inhibitors in Advanced AD: Stop or Go?
Tacrine, the first drug in this class approved for the treatment of AD, was discontinued in the United States in May 2012. Donepezil 10 mg daily has been shown ... «Medscape, Feb 15»
Thuốc Donepezil và Tacrine có chữa được chứng sa sút trí tuệ
em có thể cho ông dùng thuốc Donepezil và Tacrine được không ạ. Ông em vừa “chớm” bị, liệu 2 loại thuốc này có chữa khỏi được bệnh không ạ. Xin cảm ơn ... «Alobacsi.vn, Jan 15»
Douglas Institute researcher among new members of the Order of …
Indeed, Dr. Gauthier is credited with setting up the first multicentre Canadian study of tacrine as a treatment for Alzheimer's disease. He also founded the ... «Canada NewsWire, Jan 15»
Prominent McGillians named to Order of Canada
Gauthier is credited with setting up the first multicentre Canadian study of tacrine as a treatment for Alzheimer's disease. Robert Mellin, an associate professor in ... «McGill Reporter, Dec 14»
New Developments in Alzheimer's Disease Treatment
Donepezil, galantamine, rivastigmine, and tacrine are all cholinesterase inhibitors. They work by slowing down acetylcholinesterase, an enzyme that breaks ... «Pharmacy Times, Dec 14»
Existe-t-il un traitement contre la maladie d'Alzheimer ?
Dans les années 90, la tacrine avait été mise sur le marché et bien que porteuse de résultats satisfaisants, elle avait dû être retirée car jugée toxique pour le foie ... «Allo-Médecins.fr, Dec 14»
