QUÉ SIGNIFICA DOWNREGULATION EN INGLÉS
Regulación negativa y regulación positiva
La regulación negativa es el proceso mediante el cual una célula disminuye la cantidad de un componente celular, tal como ARN o proteína, en respuesta a una variable externa. Un aumento de un componente celular se llama upregulation. Un ejemplo de downregulation es la disminución celular en el número de receptores a una molécula, tal como una hormona o un neurotransmisor, que reduce la sensibilidad de la célula a la molécula. Este fenómeno es un ejemplo de un mecanismo de retroalimentación negativa de acción local. Un ejemplo de la regulación positiva es el aumento del número de enzimas del citocromo P450 en las células hepáticas cuando se administran moléculas xenobióticas tales como la dioxina. Algunos agonistas del receptor pueden provocar una regulación negativa de su respectivo receptor, mientras que la mayoría de los antagonistas del receptor pueden aumentar temporalmente su receptor respectivo. El desequilibrio causado por estos cambios a menudo provoca la retirada cuando se suspende el uso a largo plazo de un medicamento o fármaco. Sin embargo, típicamente el uso de ciertos antagonistas de receptores puede dañar también los receptores más rápidamente que el upregulate. Upregulation y downregulation también puede ocurrir como una respuesta a toxinas u hormonas.
definición de downregulation en el diccionario inglés
La definición de downregulation en el diccionario es una disminución de la sensibilidad, a través de la sobreexposición, a un fármaco u otro producto químico causado por una reducción en el número o la densidad de los receptores en las superficies celulares.
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10 LIBROS DEL INGLÉS RELACIONADOS CON «DOWNREGULATION»
Descubre el uso de
downregulation en la siguiente selección bibliográfica. Libros relacionados con
downregulation y pequeños extractos de los mismos para contextualizar su uso en la literatura.
1
Identification of Signal Transduction Pathways Mediating the ...
Activating mutations in the Fibroblast Growth Factor Receptor-3 gene (FGFR3) cause a number of chondrodysplasia in human, including achondroplasia (ACH) the most common form of inherited dwarfism.
2
Vesicle Trafficking in Cancer
No direct evidence of ubiquitination EphA4 Activation induced Cbl
phosphorylation, association with EphA4, [169] and Cbl induced downregulation.
No direct evidence of ubiquitination EphBl Activation does not induce Cbl
phosphorylation or ...
Yosef Yarden, Gabi Tarcic,
2013
3
HIV: Molecular Biology and Pathogenesis: Viral Mechanisms: ...
Downregulation of MHC Class 1 Nef has also been reported to downregulate the
surface expression of the major histocompatibility complex class I (MHC I) (
Schwartz et al., 1996). Similarly to CD4, sequences in the HLA cytoplasmic
domain ...
4
Characterization of ICOS-mediated B7h Shedding
The mutant clone is not defective in PMA-mediated B7h downregulation As
mentioned previously, B7h downregulation can occur in response to either BCR
signaling or ICOS binding. B7h downregulation can also occur in response to ...
5
Signal Transduction: Pathways, Mechanisms and Diseases: ...
2.4.3.4 Function of Downregulation There is probably a functional link between
the decrease in number of membrane GPCRs after chronic stimulation and the
changes in functions that are regulated by this receptor. For example, in vitro data
...
6
Nitric Oxide: Biology and Pathobiology
(1996) aDiscrepant findings in nonpulmonary endothelial cells; both upregulation
(Arnet et al., 1996; Zhang et al., 1993) and downregulation (McQuillan et al.,
1994; Phelan and Faller, 1996) of NOS III have been reported. bDiscrepant
findings ...
7
Reelin Glycoprotein: Structure, Biology and Roles in Health ...
Reelin downregulation in psychosis has been linked to GABAergic tone deficit (
Costa et al., 2001; Carboni et al., 2004). Glutamic acid decarboxylases 65, 67 (
GAD65, 67) catalyze the synthesis of the inhibitory neurotransmitter γ-aminobu-
tyric ...
Table 5.3. Alterations of miRNA Expression Related to Prognosis of Cancers
miRNA Cancer type Associated characteristics (case number) Reference [
PubMed ID] let-7 Lung cancers Downregulation, poor survival (N1⁄4143)
Takamizawa et al ...
9
MicroRNA Cancer Regulation: Advanced Concepts, ...
Table 5.1 (continued) rniRNA- gene Tumor type Mechanism Frequency [%] n =
References Prostate cancer Downregulation 63 [88] miR-192 Colorectal cancer
— p53 Mutation 34 [107] Colorectal cancer Downregulation 54 (+20 [108] (M51)
...
Ulf Schmitz, Olaf Wolkenhauer, Julio Vera,
2013
10
Mechanisms Underlying the
Downregulation of the Transporter ...
In order to examine genetic heritability of regulators of TAP-1 promoter activity, TAP- and MHC class I-deficient cells of H-2b origin were fused with wild-type fibroblasts of H-dk origin.
Alvernia Francesca Setiadi,
2007
10 NOTICIAS EN LAS QUE SE INCLUYE EL TÉRMINO «DOWNREGULATION»
Conoce de qué se habla en los medios de comunicación nacionales e internacionales y cómo se emplea el término
downregulation en el contexto de las siguientes noticias.
FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus …
The severe inhibition of HCV replication in FBP1-knockdown Huh7.5 cells was restored to a normal level by downregulation of either p53 or ... «Journal of Virology, Jul 15»
Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins …
... that EBOV IRADs have profound effects on the host adaptive immune response through massive transcriptional downregulation of DC. «Journal of Virology, Jul 15»
Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells …
These results were confirmed using short interfering RNA (siRNA)-mediated ErbB3 downregulation. MCF7 cells expressing LRIG1WT, ... «Nature.com, Jul 15»
Published Data Support Scientific Basis for Ganaxolone Use in …
... crucial neurosteroid-metabolizing enzymes and showed that downregulation of the AKR1C3 and AKR1C2 genes leads to allopregnanolone ... «MarketWatch, Jul 15»
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in …
The results showed that in MCF-7 cells OTUB1 depletion culminated in the downregulation of FOXM1, but not vice versa (Figure 2c), ... «Nature.com, Jul 15»
BIRC5/Survivin as a target for glycolysis inhibition in high-stage …
This is in line with results from Sandebring et al. who observed fragmented mitochondria after PINK1 downregulation. Parkin protein levels ... «Nature.com, Jul 15»
Differential miRNA expressions in peripheral blood mononuclear …
miR-29 downregulation is a poor prognostic marker in aggressive B-CLL. Furthermore, miR-29 can downregulate function of Tcl1, an important ... «Nature.com, Jul 15»
RhoB loss induces Rac1-dependent mesenchymal cell invasion in …
In addition, downregulation of RhoB induced Akt1 activation, which in turn activated Rac1 through the guanine-exchange factor Trio to control ... «Nature.com, Jul 15»
Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation
Downregulation of galectin-3 by EGF mediates the apoptosis of HepG2 cells. Mol Cell Biochem 2012;369:157–165. | Article | PubMed |. «Nature.com, Jul 15»
Ecophysiology of an uncultivated lineage of Aigarchaeota from an …
Flagellar synthesis may be more important during streamer formation and could explain the downregulation of these genes in this 'mature' ... «Nature.com, Jul 15»