«INTERNUCLEOTIDE»に関連する英語の本
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1
Molecular Biology of Nucleases
NATURE OF ENZYMATIC REACTION CATALYZED BY NUCLEASES Nucleases
are in essence phosphoesterases which hydrolyze the internucleotide linkage in
a nucleic acid molecule. There are different kinds of phosphoesterases.
2
Nucleic Acids in Chemistry and Biology
Phosphoramidates are internucleotide linkages in which either the 3- or 5-
oxygen of the phosphodiester is replaced by an amino group. Much of the work
with 3-phospho- ramidates was pioneered by Sergei Gryaznov.32 In general
these are ...
G. Michael Blackburn,
2006
3
Frontiers in Medicinal Chemistry
Modification of the internucleotide phosphate bond of the active dinucleotides
results in loss of anti-integrase activity. Also, there appears to be no major
advantage in terms of anti-integrase activity in going to higher molecular weight
analogs ...
Atta-ur- Rahman, Allen B. Reitz,
2005
4
Advanced Organic Chemistry of Nucleic Acids
The stability of internucleotide linkages in RNAs and DNAs has already been
discussed at length. It was pointed out that the sharp difference between the two
in this respect stems from the presence or absence of a hydroxyl at the C2' atom ...
Zoe A. Shabarova, Alexey A. Bogdanov,
2008
5
Spectroscopy of Biological Molecules: Modern Trends: Modern ...
IMPACT OF THE INTERNUCLEOTIDE LINKAGE MODIFICATION ON THE
CONFORMATION AND STRUCTURAL PROPERTIES OF "ANTISENSE"
OLIGONUCLEOTIDES: RAMAN SPECTROSCOPY J. STEPANEKa, J. HANUS',
M. ENDOVAb, ...
P. Carmona, R. Navarro, A. Hernanz,
1997
6
Photochemistry and Photobiology of Nucleic Acids
mental and theoretical considerations which cast doubt on this assignment. First
we note that while at the internucleotide separation of 3.4 A no exciton splitting is
detectable in absorption, the “normal” fluorescence of ApA is red-shifted by an ...
7
Organophosphorus Chemistry
Other internucleotide linkages that have been examined include triazole, formed
by a Click reaction. Stepwise synthesis of oligomers has been carried out
between 30-azido and 50-acetylene nucleosides, protecting the acetylene
groups with ...
D. W. Allen, J. C. Tebby, John C. Tebby,
2010
8
New Aspects in Phosphorus Chemistry I
Configurational assignments based upon known stereochemistry of the
condensation process (see above) allowed us to conclude that the slow- and fast
-[18O]-15 provide [18O]phosphorothioate internucleotide bonds of SP and RP
absolute ...
Jean-Pierre Majoral,
2002
9
HIV-1 Integrase: Mechanism and Inhibitor Design
Mechanism and Inhibitor Design Nouri Neamati. Almost as important as the
discovery of IN inhibitory activity of these dinucleotides with isomeric
deoxynucleoside components is that the internucleotide bond exhibits resistance
to cleavage by ...
10
Stereoselective Synthesis of Drugs and Natural Products
A novel palladium-catalyzed coupling strategy for the rapid synthesis of nucleic
acid analogues bearing modified backbones. Synlett 1999;7:1124—1126.
Bertram RD, Hayes CJ, Soultanas P. Vinylphosphonate internucleotide linkages
inhibit ...
Vasyl Andrushko, Natalia Andrushko,
2013
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RONALD R. BREAKER
That's because the sugar-phosphate internucleotide linkages of RNA can undergo nucleophilic attack: The sugar's 2' hydroxyl attacks the ... «Chemical & Engineering News, 3月 04»