«INTERSTRAND»に関連する英語の本
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1
The Role of A-family DNA Polymerases in DNA
Interstrand ...
One lesion repaired this way is the DNA interstrand cross-link (ICL). The ICL is a
unique type of damage in which the two strands are covalently linked. ICLs are
difficult to repair since there is no undamaged template to provide the original ...
2
Synthesis and Characterization of
Interstrand Crosslink and ...
In the latter part of this thesis, we discuss the successful preparations of phosphoramidite building blocks of thymidine glycol and 8-oxo-2'-deoxyguanosine (8-oxodG) and the dual insertion of the two single-base lesions into ODNs.
3
Advances in DNA Repair in Cancer Therapy
Kiakos K, Hartley JM et al (2010) Measurement of DNA interstrand crosslinking in
naked DNA using gel-based methods. Methods Mol Biol 613:283–302 Wang AT,
Sengerova B et al (2011) Human SNM1A and XPF-ERCC1 collaborate to ...
Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali,
2012
4
Issues in Life Sciences: Molecular Biology: 2011 Edition
in individual cells, has been adapted to measure DNA interstrand cross-links.
DNA interstrand cross-links are formed in cells by a number of commonly used
cancer chemotherapy agents and are considered to be the critical lesion formed
by ...
5
Platinum and Other Metal Coordination Compounds in Cancer ...
Interstrand cross-links continued to form in all cell lines following removal of drug,
reaching a maximum at 3-8 hours after removal of drug (data not shown) and
were subsequently repaired only slowly. In fact, in the L1210/DDP cell line ...
H. M. Pinedo, J.H. Schornagel,
1996
6
Metal Complex - DNA Interactions
An in vitro NER of a site-specific cisplatin interstrand crosslink has also been
studied using mammalian cell-free extracts containing HMG-domain proteins at
levels insufficient to block NER of the 1,2-intrastrand adducts.61 Repair of the ...
Nick Hadjiliadis, Einar Sletten,
2009
7
The Cellular Response to the Genotoxic Insult: The Question ...
Cisplatin is a commonly used chemotherapeutic agent that forms both intrastrand
and interstrand DNA crosslinks in cells.84–86 Although interstrand crosslinks are
considered more toxic to cells than intrastrand crosslinks, only about 2% of the ...
Helmut Greim, Richard J. Albertini,
2012
8
Medical Defense Against Mustard Gas: Toxic Mechanisms and ...
Lawley et a/.49 used SM-treated DNA's ability to be renatured to estimate the
proportion of G-alkyl-G adducts present in interstrand cross-linkages. Between
one-third and one-fourth of G-alkyl-G adducts are accounted for as interstrand
cross- ...
9
Triplex-forming Oligonucleotide Directed Psoralen ...
Gene targeting is a strategy used to manipulate DNA sequences at a specific site in genomes, which is valuable as a molecular tool in basic scientific research and a promising application for gene therapy.
10
DNA-protein Interactions: A Practical Approach
These results and the maximum retardation observed for the linear multimers of
the duplexes (23 bpl suggest that the natural 10.5bp repeat of B- DNA and that of
DNA fragments modified by the interstrand crosslinks are different as a ...
Andrew Arthur Travers, Malcolm Buckle,
2000
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Researchers Use Mass Spec Method to ID Proteins Involved in DNA …
As they illustrated in their paper, they monitored the action of protein complexes on replicating chromatin containing DNA interstrand crosslinks ... «GenomeWeb, 5月 15»
Nuclease-resistant synthetic drug-DNA adducts: programmable drug …
... van Rosmalen, A., Cullinane, C., Cutts, S. M. & Phillips, D. R. Stability of adriamycin-induced DNA adducts and interstrand crosslinks. Nucleic ... «Nature.com, 3月 15»
Viral DNA Becomes Less Solid, More Liquid during Infection
“We found that the sliding friction between closely packaged DNA strands, caused by interstrand repulsive interactions, is reduced by the ionic ... «Genetic Engineering & Biotechnology News, 10月 14»
Keep your cool: Isothermal PCR for next-generation sequencing
Moreover, the team also demonstrated an alternative paired-end sequencing method that uses interstrand DNA photo cross-linking to ... «Medical Xpress, 8月 13»
Protein engineering - from the humble spider to the nanotechnology …
Interstrand H-bonds (thick yellow lines in insert) act as mechanical clamps that resist unfolding. (Image: Dr. Buehler, MIT). Buehler's group has ... «Nanowerk LLC, 2月 08»