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1
Foye's Principles of Medicinal Chemistry
40.9) has been attributed to formation of testosterone via systemic ester
hydrolysis of lymphatically transported testosterone undecanoate (73). Its oral
bioavailability was approximately 3%. Lymphatically transported testosterone
undecanoate ...
Thomas L. Lemke, David A. Williams, 2012
2
Drug Targeting Technology: Physical Chemical Biological Methods
Most of the mass of lymphatically transported drugs appears to be contained
within the chylomicron and VLDL fraction of the lymph. A small proportion is also
associated with the nonlipoprotein fraction because of re-equilibration of drug
within ...
3
New Frontiers in Angiogenesis
As with LYVE-1 and VEGFR-3, podoplanin expression continues in these
lymphatically-committed cells but is progressively down-regulated in venous
endothelial cells178. By the time of birth, podoplanin expression is generally
restricted to ...
4
Prodrugs: challenges and rewards. P. 1
Recently, we investigated the quantitative contributions of lymphatically absorbed
TU to systemic T exposure (Shackleford et al., 2003). In this study, TU was
administered orally to postprandial thoracic lymph duct-cannulated dogs and the
...
Valentino J. Stella, 2007
5
Molecular Biology of the Cell
Lymphatically differentiating budding endothelial cells and resident endothelial
cells in a newly formed lymphatic vessel are costained positively for Proxl and for
FGFR-3 (D). Similarly, LYVE-1 -positive lymphatic endothelial cells express ...
6
Secrets about Bioidentical Hormones to Lose Fat and Prevent ...
It is absorbed lymphatically. Testosterone undecanoate is a testosterone ester (
not bioidentical). It is absorbed through the small intestine into the lymphatic
system. Because it circumvents the liver, it is a safer oral form of testosterone.
7
Kaplan Medical PANCE: The Complete Guide to Licensing Exam ...
Chlamydia psittaci (choice E) causes psittacosis from contact with birds and is not
sexually transmitted. 2. The correct choice is A. Papillary carcinoma of the thyroid
makes up 80% of all thyroid cancers. The disease spreads lymphatically and ...
8
Intracellular Delivery: Fundamentals and Applications
Similarly, after subcutaneous injection of phosphatidylserine containing
liposomes into rats the retention of the lymphatically available dose in regional
lymph nodes is over 300% of the injected dose per gram, approximately three-
fold higher ...
9
Applied Veterinary Clinical Nutrition
The percentage absorbed via lymphatics increases from less than 10% to 80%
as chain length increases from capric acid (8:0) to lauric acid (12:0), while the
MAG is still absorbed lymphatically (Mu and Hoy 2000). Thus, such medium-
chain ...
Andrea J. Fascetti, Sean J. Delaney, 2012
10
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery
J Pharm Pharmacol 2002; 54:29-41. Shackleford DM, Faassen WA, Houwing N,
Lass H, Edwards GA, Porter CJ, Charman WN. Contribution of lymphatically
transported testosterone undecanoate to the systemic exposure of testosterone
after ...
Ronald Borchardt, Edward Kerns, Michael Hageman, 2007
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Comparative Analysis Reveals Undervalued Asset In Antares …
The developers of oral testosterone overcame this problem by changing the drug's structure, so that it is absorbed lymphatically instead of ... «Seeking Alpha, 9月 14»