«PARTITION COEFFICIENT»に関連する英語の本
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1
Octanol-Water
Partition Coefficients: Fundamentals and ...
Collander made systematic partition coefficient measurements using isobu- tanol
-water (Collander, 1950), ether-water (Collander, 1949), oleyl or octyl alcohol-
water (Collander, 1951) solvent pairs, and related ether-water partition coefficient
...
2
Introduction to the Pharmaceutical Sciences
However, measurement of partition coefficient provides a simple in vitro method
to make some prediction about the behavior of a compound in the body and to
select the most promising drug candidates from a large pool of compounds.
3
Physiology Cases and Problems
Permeability is related to the diffusion coefficient as follows: P KD x = ∆ where P =
permeability K = partition coefficient D = diffusion coefficient Δx = membrane
thickness The equation states that permeability (P) is directly correlated with the ...
4
Essentials of Pharmaceutical Chemistry
The partition coefficient of the unionised drug (the true partition coefficient)
should remain constant and is given by [drug] in organic phase p= [unionised
drug] in water 0.8 mL-' 0.4 mg mL~' the same answer as obtained above. Using
the total ...
5
Physicochemical Principles of Pharmacy
If ionisation and its consequences are neglected, an apparent partition coefficient
, Papp, is obtained simply by assay of both phases, which will provide information
on how much of the drug is present in each phase, regardless of status.
Alexander Taylor Florence, D. Attwood, 2006
6
Partition and Adsorption of Organic Contaminants in ...
For solid solutes, the heat of fusion (Dfus), which affects the solid solubility in a
single phase (e.g., water), has no net effect on the solute partition coefficient (Ksw
) or on the heat of solute partition (Dsw). H H For most low-polarity organic ...
7
Principles of Pharmacology: The Pathophysiologic Basis of ...
Partition Coefficients The solvent/gas partition coefficient, A.(solvent/gas), defines
the solubility of a gas in a solvent or, in other words, how the gas "partitions"
between its gaseous state and the solution. More specifically, \(solvent/gas) is the
...
8
Pharmacology: Drug Actions and Reactions
This ratio is known as the lipid/water partition coefficient. The lipid phase may be
any fat solvent, such as ether, chloroform or a vegetable oil. Overton chose
cottonseed oil as the lipid phase for his determination of the lipid/water partition ...
Carol T. Walsh, Rochelle D. Schwartz-Bloom, 2004
... 0.5 and 1.5 grams. The results obtained are shown in table 20.1. Table 20.1
Equilibrium concentrations of butanedioic acid in ether and. 20 Equilibria The
equilibrium of a solute between two immiscible solvents - the partition coefficient
294.
Graham Hill, John Holman, 2000
[I2(aq)l = Constant [I2(trichlorocthane)] The constant is called the partition
coefficient or distribution coefficient. It is constant for a particular temperature. The
general form of this equation is expressed as: [Solute in upper layer] = Partition ...
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Liquid chromatography-mass spectrometry platform for both small …
A table with molar mass (Mm), octanol-water partition coefficient (log P) and pKa values of all analytes are included (values obtained from ... «Nature.com, 3月 15»
Making Roads a Safer Place with Headspace GC Analysis
The partition coefficient (K) is simply the ratio of the analyte concentration in the sample (cs) and the analyte concentration in the gas phase (cg) ... «Chromatography Today, 12月 14»
Simulation predicts epidermal responses to compounds
Two key inputs to the model are a compound's molecular weight and its octanol–water partition coefficient (a ratio of concentrations of the ... «Phys.Org, 11月 14»
Using NMR to Measure Lipophilicity
This involves the computation of partition coefficient (Pow) and logarithm (log Pow) of water and 1-octanol. According to Lipinski's "Rule of 5" for ... «Azom.com, 9月 14»
ACD/Labs Releases a New Version of ACD/ChemSketch Freeware
... than 50 atoms and 3 ring structures, and get predictions of the octanol-water partition coefficient, logP, along with other molecular descriptors. «WebWire, 11月 13»
The Kety-Schmidt Technique for Quantitative Perfusion and Oxygen …
... output weighted with a blood-brain partition coefficient, empirically determined to be 1.0 in primates, and a blood-gas partition coefficient. «AJNR, 9月 13»
Clean beans: How washing and boiling affect pesticides on green …
These values were explained in terms of the octanol-water partition coefficients (Kow), supporting the fact that the partition coefficient between ... «separationsNOW.com, 8月 13»
Fuel matters: Insights into enzymatic conversion
Altering the crystalline structure of cellulose from its native form to another can lower its binding partition coefficient for fungal cellulose ... «spectroscopyNOW.com, 6月 13»
Two-pronged pesticide attack: Ionic liquids and magnetic …
As well as diminishing the green credentials of the method, it can also reduce the partition coefficient of the analytes and harm recovery levels. «separationsNOW.com, 2月 13»
All Those Drug-Likeness Papers: A Bit Too Neat to be True?
Why is calculated octanol/water partition coefficient (ClogP) used to specify Ro50s low polarity limit when the high polarity cut off is defined in ... «Corante, 2月 13»
