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1
Clinical Primer of Rheumatology - 273페이지
But even in these more extreme cases of renal failure, the dose of allopurinol frequently needs to be escalated to achieve normouricemia. Even after allopurinol has been started, it is important to continue to look for and correct any secondary ...
William J. Koopman, Dennis W. Boulware, Gustavo R. Heudebert, 2003
2
Drug Therapy in Nursing - 446페이지
Pharmacotherapeutics Allopurinol is indicated for the management of chronic gout, recurrent calcium renal stones, and hyperuricemia related to cancer or tumor lysis syndrome. Off-label uses include prevention of ischemic reperfusion tissue ...
Diane S. Aschenbrenner, Samantha J. Venable, 2009
3
A Clinician's Pearls & Myths in Rheumatology - 363페이지
For those with bulky tophi, resorption will occur more quickly if a serum level of 3.0–4.0 mg/dL can be achieved (Figure Courtesy of Dr. John Stone) Pearl: Allopurinol is often underdosed. Comment: Allopurinol is approved by the FDA for the ...
4
Therapy of Renal Diseases and Related Disorders - 329페이지
Allopurinol, is frequently utilized to reduce the body urate pool and secondarily decrease the amounts of urate filtered and secreted by the kidneys. Allopurinol has become almost standard therapy for preventing acute uric acid nephropathy ...
Wadi N. Suki, Shaul G. Massry, 2012
5
Primer on the Rheumatic Diseases - 260페이지
The currently available pharmacotherapies for serum urate lowering are: (1) allopurinol, a xanthine oxidase inhibitor, which reduces uric acid production; or (2) uricosuric agents (exemplified by probenecid), which increase renal uric acid ...
John H. Klippel, John H. Stone, L eslie J. Crofford, 2008
6
Worst Pills, Best Pills: A Consumer's Guide to Avoiding ... - 332페이지
Limited Use Allopurinol (al oh pure i nole) ZYLOPRIM (Prometheus) GENERIC: available FAMILY: Drugs for Arthritis and Gout (see pp. 283 and 287) PREGNANCY WARNING There is a published report of allopurinol causing deaths and ...
7
Medical Biochemistry - 657페이지
4 + --" FIGURE 27-17 Inhibition of xanthine oxidase by allopurinol, an analogue of hypoxanthine. N7 and C# of hypoxanthine are reversed in allopurinol. Allopurinol, a suicide enzyme-inactivator, is converted to alloxanthine, which binds tightly ...
8
Hospital for Special Surgery Manual of Rheumatology and ...
If patients have kidney stones or tophi, allopurinol would be the drug of choice. The goal is to decrease serum urate level below 6 mg/dL, and in refractory patients it may need to be maintained below 5 mg/dL. Urate-lowering treatment is not ...
9
Foye's Principles of Medicinal Chemistry - 1001페이지
It was subsequently found that allopurinol serves as a substrate for xanthine oxidase (15 to 20 times the affinity of xanthine) and reversibly inhibits that enzyme. Normally, uric acid is a major metabolic end product in humans. When allopurinol ...
Thomas L. Lemke, David A. Williams, 2008
10
The Australian Drug Guide: Every Person's Guide to ... - 15페이지
After several months dose may be lowered to 100 mg daily. How to take the drug Allopurinol should only be commenced 2-3 weeks after an acute attack has resolved. Once started this drug will need to be taken for some years for chronic gout.
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SK케미칼, 통풍치료 신약 '페브릭'
그러나, 통풍 치료의 1차 선택약으로 사용되어 온 알로푸리놀 계열 약물은 이미 43년 전에 개발된 약물로서, 알로푸리놀 과민성 증후군(AHS) 등의 치명적인 부작용을 ... «헬스코리아뉴스, 7月 11»
