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1
Drug Therapy in Nursing - 188페이지
glaucoma, pilocarpine contracts the ciliary muscle, increasing the outflow of aqueous humor, which reduces intraocular pressure. In closed-angle glaucoma, pilocarpine-induced miosis opens the angle of the anterior chamber of the eye, ...
Diane S. Aschenbrenner, Samantha J. Venable, 2009
2
Clinical Ocular Pharmacology - 47페이지
The pilocarpine contained within the central reservoir is in equilibrium between the ionized, water-soluble form and the unionized, lipid-soluble form. In the aqueous tear layer, the lipid form of the drug is released." During the initial 6 to 8 hours ...
3
Manual of Ocular Diagnosis and Therapy - 270페이지
In younger patients, this is usually a disabling visual side effect that prevents use of pilocarpine. Most patients above the age of 50 years do not develop such pilocarpineinduced myopia, presumably because of an inelasticity of their lens that ...
Deborah Pavan-Langston, 2008
4
Chemical Stability of Pharmaceuticals: A Handbook for ... - 675페이지
NS. mol. wt. 208.25 Forms Available Free base (pi locarpine); pilocarpine hydrochloride; pilocarpine nitrate. Physical Properties 0il or crystals; melting point 34°C. Soluble in water, alcohol, and chloroform; in soluble in ether. At 15°C, pKa1 ...
Kenneth A. Connors, Kenneth Antonio Connors, Gordon L. Amidon, 1986
5
Glaucoma: Expert Consult Premium Edition - Enhanced Online ...
Echothiophate iodide is as effective alone as in combination with pilocarpine.13 Furthermore, pretreating monkeys with echothiophate iodide demonstrated marked subsensitivity to pilocarpine, and required several weeks or months to recover ...
Tarek M. Shaarawy, Mark B. Sherwood, R. A. Hitchings, 2009
6
Models of Seizures and Epilepsy - 435페이지
Pilocarpine can trigger acute seizures after intracerebroventricular (Croiset and De Wied, 1992) and intrahippocampal administration (Millan et al., 1992). In addition, the intrahippocampal administration of pilocarpine in rats is able to trigger ...
Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé, 2005
7
Textbook of Ophthalmology - 1484페이지
Another polymer (Piloplex) when given twice a day has more effect than plain pilocarpine. Recent data have shown that pilocarpine when given in a synthetic biosoluble matrix provides drug release upto 24 hours when placed in the ...
Sunita Agarwal, Athiya Agarwal, Lucio Buratto, 2002
D. Pilocarpine The alkaloid pilocarpine [pye-loe-KAR-peen] is a tertiary amine and is stable to hydrolysis by acetylcholinesterase (see Figure 4.5). Compared with acetylcholine and its derivatives, it is far less potent, but it is uncharged and will ...
Richard Finkel (PharmD.), Michelle Alexia Clark, Luigi X. Cubeddu, 2009
9
Burket's Oral Medicine - 215페이지
More than 24 agents have been proposed as means of stimulating salivary output systemically. Four have been examined extensively in controlled clinical trials; these are bromhexine, anetholetrithione, pilocarpine HCl, and cevimeline HCl.
Lester William Burket, Martin S. Greenberg, Michael Glick, 2008
10
Becker-Shaffer's Diagnosis and Therapy of the Glaucomas - 423페이지
Several formulations containing both pilocarpine and a β-blocking agent have been reported to be synergistic and have the convenience of a twice-daily dosage with a single drop.46–51 These studies encompass most of the available topical ...
Robert L. Stamper, Marc F. Lieberman, Michael V. Drake, 2009
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입마름, 석달이상 땐 내과에 가보세요
쇼그렌 증후군의 주요 증상인 구강 및 안구 건조 증상은 국내에서 유일하게 FDA 승인을 받은 필로카르핀 제제를 복용함으로써 개선이 가능하다. 특히 구강건조 증상 ... «경향신문, 12月 14»
중년 여성, 입 마르고 눈 뻑뻑하면…
국내에서 유일하게 미국 식품의약국(FDA) 승인을 받은 치료제(성분명 필로카르핀)는 구강 및 안구 건조증을 유의하게 개선시켜 일상생활의 편의를 돕고 구강과 안구 ... «경향신문, 11月 14»
입냄새, 본인만 모르는 불쾌함
필로카르핀은 부교감신경촉진제로 장기간 쓰면 녹내장 천식을 유발하거나 악화시키므로 아주 심한 구강건조증에만 쓴다. 이런 약물은 사용할 때만 효과가 나타나는 ... «한국경제, 5月 07»
