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1
Abl Family Kinases in Development and Disease
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease.
2
Determining the Critical Downstream Effectors of BCR/
ABL.
The unexpected role for BCR/ABL signaling through the RAL pathway warrants
further investigation. Chapter III explored similarities and differences in BCR/ABL
and TEL/ABL mediated induction of CML and B-ALL. Under myeloid conditions ...
3
The Role of
Abl Tyrosine Kinase in Cell Spreading
Hua Jin. Results Dimerization of Abl-FKBP inhibits cell spreading on fibronectin
We generated an Abl-FKBP, as well as an Abl kinase defective-FKBP (AblKD-
FKBP) fusion protein and adopted the strategy of activating Abl kinase activity
with a ...
4
The Localization of C-
Abl in Alzheimer's Disease
Zheng Jing. Genetic studies of the Drosophila homolog of c-Abl, Drosophila Abl (
D-Abl) suggest that D-Abl integrates the information from axon guidance and
growth factor receptors and mediates to cytoskeleton, thus promoting cytoskeletal
...
5
Regulation of Actin Cytoskeleton Remodeling and Focal ...
Primary structure of Abl family non- receptor tyrosine kinases Abl family proteins
are 150 kDa proteins, and are comprised of the c-Abl and Abl related gene (Arg)
non-receptor tyrosine kinases in mammals (Koleske et al., 1998; Kruh et al., ...
6
Regulation of Cell Adhesion and Cell Death: The Roles of the ...
Abl protein contains three NLSs, each of which can independently direct Abl into
the nucleus [28]. Abl can also undergo nuclear export as it contains a NES at its
Cterminus [29]. In proliferating fibroblasts, Abl is evenly distributed in the ...
7
RIN1 Activates
ABL Oncoproteins and is Required for Full ...
The same pattern is seen regardless of the breakpoint within BCR. Even with
fusion partners other than BCR, the ABL 1 breakpoint resides between the first
alternate exon (lb) and the second exon (2a) [24]. Moreover, oncogenic
translocations ...
8
Two Modes of Auto-regulation in the Cell Signaling Proteins ...
For example, the drug imatinib, which is used to treat chronic myeloid leukemia,
blocks the activity of BCR- Abl, a constitutively activated mutant of the tyrosine
kinase c-Abl, but does not block the activity of c-Src, a close relative of c-Abl.
9
Neoplastic Diseases of the Blood
ABL results in growth arrest of cells during Gl possibly through direct interaction
with the p53 and the retinoblastoma tumor suppressor products.46 It has also
been suggested that ABL is activated in the stress response to DNA damaging ...
10
Blood: Principles and Practice of Hematology
C-ABL has 11 exons and expands over 230 kilobases (kb). It is located on
chromosome 9q34 and encodes a 140-kilodalton (kd) protein, p!40, with weak
tyrosine kinase activity (23). Of importance, C-ABL has to alternate exon 1
sequences ...
Robert I. Handin, Samuel E. Lux, Thomas P. Stossel,
2003