«SPHINGOMYELIN» 관련 영어 책
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CHAPTER 4 Sphingomyelin: metabolism, chemical synthesis, chemical and
physical properties YECHEZKEL BARENHOLZ and SHIMON GATT Laboratory of
Neurochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel
1.
John Nigel Hawthorne, 1982
2
Principles of Orthomolecularism
PDGF induces sphingomyelin hydrolysis to ceramide (by sphingomyelinase),
which is further metabolised (by ceramidase and sphingosine kinase) to
sphingosine and sphingosine-1-phosphate. TNF-α activates only
sphingomyelinase that ...
3
Advances in Cholesterol Research
Thus, in a cosonicated vesicle of POPC and SSP where sphingomyelin is the
higher melting component, the fluorescent sterol does not show a preferential
interaction with the sphingomyelin. Instead, the cholestatrienol preferentially
interacts ...
Mojtaba Esfahani, John B. Swaney, 1990
4
Sphingolipids as Signaling and Regulatory Molecules
However, in vitro studies of primary hip- pocampal neurons from GCS deficient
mice showed defects in neurite outgrowth in culture.54,55 Sphingomyelin
Synthesis The most abundant complex sphingolipids in mammalian cells are the
...
Charles Chalfant, Maurizio Del Poeta, 2011
5
Bioactive Components of Milk
Important sphingolipids include sphingomyelin, gluco- sylceramide, and
lactosylceramide, while lysophosphatidylcholine and phosphatidic acid are rarely
detected (Christie et al., 1987). Sphingolipids are a class of phospholipids
containing a ...
6
Apoptotis: Pharmacological Implications and Therapeutic ...
of glycerophospholipids in mitogenic pathways, the sphingomyelin cycle was
identified [2]. The sphingomyelin cycle is activated when the binding of an
extracellular ligand to its receptor activates a sphingomyelinase, which
hydrolyzes ...
7
Springer Handbook of Enzymes
... 30-31, 33, 40, 42] Km-Value (mM) 0.00059 <5> (sphingomyelin) [43] 0.024 <3>
(sphingomyelin) [9] 0.025 <3> (sphingomyelin) [14, 33-34] 0.027 <6> (2-n-
hexadecanoylamino-4-nitrophenylphosphorylcholine) [10] 0.032 <3> (
sphingomyelin) ...
Dietmar Schomburg, Ida Schomburg, 2003
Table 3 Distribution and Half-Lives of C18:Sphingomyelin and C24:
Sphingomyelin in Microsomes and Myelin of Rat Brain Microsomes Myelin % of
total t]/2 % of total ti/2 sphingomyelin (days) sphingomyelin (days) CI
Sphingomyelin 82 14 36 ...
Russell E. Martenson, 1992
9
Handbook of Nutraceuticals and Functional Foods, Third Edition
Robert E.C. Wildman, Robert Wildman, Taylor C. Wallace. oil, etc.) that contain
very low amounts of sphingolipids. Sphingomyelin supplementation at 0.1% of
the diet (wt/wt) reduced the number of aberrant colonic crypt foci (an early marker
of ...
Robert E.C. Wildman, Robert Wildman, Taylor C. Wallace, 2000
10
Transmembrane Dynamics of Lipids
There, ceramide has to cross the Golgi membrane to reach the sphingomyelin
synthase SMS1, which is situated with its active center on the lumenal side [58,59
] of the trans-Golgi [33]. It is not fully clear to what extent sphingomyelin is limited
...
Philippe Devaux, Andreas Herrmann, 2012
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Imaging lipid rafts reveals some surprises
Artist's rendering of the distribution of sphingomyelin (red spheres with yellow heads) in a lipid raft. (Image: Mikiko Sodeoka, RIKEN Synthetic Organic Chemistry ... «Nanowerk, 7월 15»
Genetic Underpinnings of Intermediate Phenotypes in Psychosis
... networks, including neurogenesis-axon guidance and cell adhesion, and metabolic networks, including lysophosphatidylserine and sphingomyelin pathways. «Psychiatric Times, 7월 15»
Genzyme kicks off paediatric trial of olipudase alfa
... Niemann-Pick disease type B), a serious and life-threatening disorder caused by insufficient activity of the enzyme ASM, which leads to sphingomyelin toxicity. «PharmaTimes, 6월 15»
Healthcare Stocks in Actions: Sanofi (NYSE:SNY), Eli Lilly and …
... and life-threatening disorder caused by insufficient activity of the enzyme acid sphingomyelinase (ASM), which results in toxic accumulation of sphingomyelin. «StreetWise Report, 6월 15»
Genzyme nabs breakthrough designation for rare enzyme disorder
Genzyme's drug is designed to replace the enzyme, which metabolizes sphingomyelin. When sphingomyelin is not processed properly it accumulates in the ... «BioPharma Dive, 6월 15»
Pre-Market Stocks Roundup: Novogen (NASDAQ:NVGN), Sanofi SA …
Supplementing the defective or deficient native enzyme with olipudase alfa allows for the breakdown of sphingomyelin, whose accumulation is responsible for ... «wsnewspublishers, 6월 15»
Nuclear techniques confirm unique biology of human eye lens
The lipid, a sphingomyelin, is more abundant than another type of phospholipid in the human lens. Lipids in the core of the nucleus are as old as the lens itself. «Phys.Org, 5월 15»
TREM2 function in microglia
... disease (AD)-associated variant (TREM2 R47H) exhibits defective recognition of anionic lipids, such as phosphatidylserine, sulfatides and sphingomyelin, that ... «Nature.com, 4월 15»
DEGS2 polymorphism associated with cognition in schizophrenia is …
Sphingomyelin consists of a ceramide with phosphocholine, and is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin ... «Nature.com, 4월 15»
Genzyme Presents Data from its Phase 1b Program for Niemann …
This enzyme is found in special compartments within cells called lysosomes and is required to metabolize a lipid called sphingomyelin. If ASM is absent or not ... «Business Wire, 2월 15»
