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Although the reasons for Michigan's malaise are varied, one big reason is our state's almost uniquely uncompetitive tax structure, which one General Motors official called the costliest of all jurisdictions where GM operates.
The evidence is inarguable that Australia is becoming too expensive and too uncompetitive to do export-oriented business. Africans want to work, and its workers are willing to work for less than $2 per day. Such statistics make me worry for this country's future. We are becoming a high-cost and high-risk nation for investment.
I think at the end of the day, the real sick man of Europe is liable to turn out to be France, not Greece, not Portugal, not Spain, not Italy. The reason is France is very uncompetitive to begin with on a global scale, and the measures that Hollande has been putting in have been very, very negative from the point of view of economic growth.
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1
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide ...
Hence the augmentation of the affinity of an uncompetitive inhibitor that
accompanies ES complex formation must be balanced by an equal augmentation
of substrate affinity for the El complex. The result of this is that the apparent
values of ...
2
Handbook of Neurochemistry and Molecular Neurobiology: ...
Figure 4-11 Full and partial uncompetitive inhibitory mechanisms. (a) Reaction
scheme for full uncompetitive inhibition indicates ordered binding of substrate
and inhibitor to two mutually exclusive sites. The presence of inhibitor prevents ...
Glen Baker, Susan Dunn, Abel Lajtha, 2007
3
Drug Metabolism in Drug Design and Development
4.7.5 Uncompetitive Inhibition The final type of inhibition that will be discussed is
that of uncompetitive inhibition. In this case, the inhibitor decreases the apparent
value of Vmax but has no effect on Vmax/Km; in other words, both Vmax and Km
...
Donglu Zhang, Mingshe Zhu, William G. Humphreys, 2007
4
Glutamate Receptors in Peripheral Tissue: Excitatory ...
It has since been well characterized electrophysiologically and shown to be an
uncompetitive NMDA receptor antagonist with an IC50 of ~2 p.M. The therapeutic
index is much better than the high-affinity uncompetitive antagonist MK-801.
Santokh Gill, Olga Pulido, 2007
5
Textbook of Drug Design and Discovery, Third Edition
Nevertheless, continued research will be required to provide additional drugs,
hopefully ones that are more refractory to target mutations, for the treatment of
this devastating disease. An uncompetitive inhibitor is one that binds exclusively
to ...
Tommy Liljefors, Povl Krogsgaard-Larsen, Ulf Madsen, 2003
6
Enzyme Kinetics for Systems Biology
Uncompetitive inhibition occurs when an inhibitor only binds when substrate is
bound to the enzyme, Figure 4.2(b). One could imagine that substrate binding
causes a conformational change which allows the inhibitor to subsequently bind.
7
Fundamentals of Enzyme Kinetics
KgrP. The uncompetitive inhibition constant Kiu may be symbolized simply as K,-
when the uncompetitive character can be assumed, but as this will be rather
unusual it is best to use the more explicit symbol. Comparison of equations 6.9-
6.11 ...
Athel Cornish-Bowden, 2013
8
Molecular Pharmacology V3: The Model of Action of Biology ...
In the case of an uncompetitive interaction, the presence of a molecule of drug A
on the receptor is a prerequisite for its occupation by the molecule of a drug B. In
fact, the drug A together with its specific receptor takes part in the formation of ...
9
Comprehensive Toxicology
For an irreversible inhibitor, the Vmax versus [E]T plot has the same slope as the
control reaction but intercepts at a lower [E]T corresponding to the amount of
active enzyme remaining (Segel 1975, pp 100–226). Uncompetitive inhibitors
bind ...
10
International Antitrust Law & Policy: Fordham Corporate Law 2001
A concentrated market is not necessarily an uncompetitive market. If there is an
antitrust problem in a concentrated market, it is because there is too little
competition, not primarily because it is concentrated. A market may be
uncompetitive for, ...
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Are uncompetitive Japanese contractors to blame for Zaha's New …
Zaha Hadid Architects is not going away quietly, but cogently. In a statement forwarded by the Japan Olympic Committee, ZHA details the origins of what would ... «Archinect, 7월 15»
Dodd-Frank Making U.S. Banks Uncompetitive, Says White & Case …
NEW YORK (TheStreet) -- America's banks are indeed safer and sounder than they were prior to the passage of Dodd-Frank five years ago this week. «TheStreet.com, 7월 15»
Most Russian car plants are uncompetitive, AvtoVAZ CEO says
BIRMINGHAM, England -- Most vehicle assembly plants in Russia are not cost competitive because they are not producing enough vehicles, said Bo Andersson, ... «Automotive News, 6월 15»
Limited FDI inflows show that the Philippines is uncompetitive
It's crunch time. ASEAN integration is upon us. We have reasons to rejoice for the potentially large markets and higher investor interests that ASEAN economic ... «BusinessWorld Online Edition, 5월 15»
Indian REITs hobbled by taxes making yields uncompetitive to RMZ
REITs have the potential to provide a new source of cash to Indian developers that have struggled to reduce debt with interest rates among the highest in Asia, ... «Livemint, 3월 15»
'Green power levies making British steel uncompetitive'
Britain's steel industry is calling for the Chancellor to give it a £135m boost so it can compete with foreign rivals as UK producers struggle in the face of soaring ... «Telegraph.co.uk, 3월 15»
Hike in service tax will make industry uncompetitive: AEPC
Unhappy with certain Budget proposals, Garment exporters body AEPC today said increase in service tax would make the industry uncompetitive in the global ... «Business Standard, 3월 15»
Help to Buy 'makes shared ownership uncompetitive in north'
Providers are not offering shared ownership properties in low-value areas of the north of England, because it is 'impossible' to make it competitive against Help ... «Inside Housing, 2월 15»
Energy costs are making the UK uncompetitive, says power …
Energy company boss Guss Weiss believes high power costs are making UK business 'dangerously' uncompetitive, and has doubts they are achieving their ... «The Journal, 2월 15»
Union challenges Rauner charge of 'uncompetitive bidding' on …
Gov. Bruce Rauner looks to amend the criminal justice system by reforming parole and preventing crime. Gov. Bruce Rauner looks to amend the criminal justice ... «Chicago Tribune, 2월 15»
