इंग्रजी शब्दकोशामध्ये "gyrase" याचा अर्थ

इंग्रजी मध्ये GYRASE चा उच्चार

gyrase  [ˈdʒaɪˌreɪz]

इंग्रजी मध्ये GYRASE म्हणजे काय?

डीएनए ग्रिझ

DNA gyrase

डीएनए ग्रिझ, ज्याला फक्त गइरास असे संबोधले जाते, हे ऍन्झाइम असते जे पोकळीत आराम देते आणि दुहेरी क्षीण डीएनए हेलिसेकद्वारे अपरिहार्य होते. त्यामुळे डीएनएचे नकारात्मक सुपरकोईंग होते. बॅक्टेरिया डीएनए ग्रिझ हे अनेक अँटीबायोटिक्सचे लक्ष्य आहे, जसे नॅलिडिएक्सिक ऍसिड, न्युबिओओसिइन आणि सीप्रोफ्लोक्सासिन. हे डीएनएमध्ये टेम्प्लेट ओपेरकोल्स बनवते जेणेकरून क्रॉसिंग तयार होईल, नंतर दुहेरी हेलिकॉसेसमध्ये एक कापले जाईल आणि ब्रेक सोडण्यापूर्वी त्यातून इतर पुरवणे शक्य होते, प्रत्येक एनझाइमिक स्टेपमध्ये लिंकिंग नंबर दोन ने बदलून. ही प्रक्रिया प्रोकयायरोट्समध्ये होते, ज्याचे एकल परिपत्रक डीएनए डीएनए ग्रिझने कापून टाकले जाते आणि दोन टोक नंतर सुपरकोइल तयार करण्यासाठी एकमेकांभोवती फिरवले आहेत. अगदी अलीकडे, मॅरीअल परजीवी प्लॅस्मिथिअम फॅल्सीपीरम नावाच्या एपिकॉलास्टमध्ये गॅरास सापडला आहे, एक एका कोलाचा युकेरियट. डि.एन.ए. मध्ये नकारार्थी सुपरकोइल परिचय करणारी ग्रिझची अद्वितीय क्षमता म्हणजे जिवाणू डीएनएला मुक्त नकारात्मक सुपरकोलसची परवानगी मिळते. डीएनए प्रतिकृती दरम्यान सकारात्मक supercoils आराम करण्यासाठी gyrase क्षमता नाटक येतो.

DNA gyrase, often referred to simply as gyrase, is an enzyme that relieves strain while double-strand DNA is being unwound by helicase. This causes negative supercoiling of the DNA. Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid, novobiocin, and ciprofloxacin. It supercoils into DNA by looping the template so as to form a crossing, then cutting one of the double helices and passing the other through it before releasing the break, changing the linking number by two in each enzymatic step. This process occurs in prokaryotes, whose single circular DNA is cut by DNA gyrase and the two ends are then twisted around each other to form supercoils. Very recently, gyrase has been found in the apicoplast of the malarial parasite Plasmodium falciparum, a unicellular eukaryote. The unique ability of gyrase to introduce negative supercoils into DNA is what allows bacterial DNA to have free negative supercoils. The ability of gyrase to relax positive supercoils comes into play during DNA replication.

इंग्रजी शब्दकोशातील gyrase व्याख्या

शब्दकोशात गइरासची परिभाषा हा टॉपीओसॉमेरेझ एंजाइम आहे.

GYRASE चे भाषांतर

आमच्या इंग्रजी बहुभाषी भाषांतरकर्त्यासह gyrase चे 25 भाषांमधील भाषांतर शोधा.

या विभागात सादर केलेल्या इंग्रजी चा gyrase इतर भाषेतली भाषांतरे स्वयंचलित सांख्यिकीय भाषांतराद्वारे प्राप्त झाली आहेत; जिथे आवश्यक भाषांतर युनिट इंग्रजी चा «gyrase» हा शब्द आहे.

• भाषांतरकर्ता इंग्रजी - चीनी: 解旋酶
• भाषांतरकर्ता इंग्रजी - स्पॅनिश: girasa
• इंग्रजी: gyrase
• भाषांतरकर्ता इंग्रजी - हिन्दी: कर्णक
• भाषांतरकर्ता इंग्रजी - अरबी: gyrase
• भाषांतरकर्ता इंग्रजी - रशियन: гираза
• भाषांतरकर्ता इंग्रजी - पोर्तुगीज: gyrase
• भाषांतरकर्ता इंग्रजी - बंगाली: gyrase
• भाषांतरकर्ता इंग्रजी - फ्रेंच: gyrase
• भाषांतरकर्ता इंग्रजी - मलय: Gyrase
• भाषांतरकर्ता इंग्रजी - जर्मन: Gyrase
• भाषांतरकर्ता इंग्रजी - जपानी: ジャイレース
• भाषांतरकर्ता इंग्रजी - कोरियन: 자이라
• भाषांतरकर्ता इंग्रजी - जावानीज: Gyrase
• भाषांतरकर्ता इंग्रजी - व्हिएतनामी: gyrase
• भाषांतरकर्ता इंग्रजी - तमिळ: கிரேஸைத்
• भाषांतरकर्ता इंग्रजी - मराठी: गॅरीस
• भाषांतरकर्ता इंग्रजी - तुर्की: giraz
• भाषांतरकर्ता इंग्रजी - इटालियन: girasi
• भाषांतरकर्ता इंग्रजी - पोलिश: gyraza
• भाषांतरकर्ता इंग्रजी - युक्रेनियन: гіраза
• भाषांतरकर्ता इंग्रजी - रोमानियन: girazei
• भाषांतरकर्ता इंग्रजी - ग्रीक: γυράση
• भाषांतरकर्ता इंग्रजी - अफ्रिकान्स: girase
• भाषांतरकर्ता इंग्रजी - स्वीडिश: gyras
• भाषांतरकर्ता इंग्रजी - नॉर्वेजियन: gyrase

«GYRASE» संबंधित इंग्रजी पुस्तके

खालील ग्रंथसूची निवडीमध्ये gyrase चा वापर शोधा. इंग्रजी साहित्यामध्ये वापराचा संदर्भ देण्यासाठी gyrase शी संबंधित पुस्तके आणि त्याचे थोडक्यात उतारे.

Molecular Biology: Academic Cell Update Edition

Ciprofloxacin kills bacteria by inhibiting DNA gyrase. It is harmless to animals as they do not use DNA gyrase for compacting their DNA. Supercoiled DNA One strand passed through nick and resealed Strand nick Type I topoisomerases one  ...

David P. Clark, 2009

Cancer Research Supported Under Biomed1

Comparison of drug-promoted DNA cleavage mediated by topoisomerase II and hy DNA gyrase (Milan, Newcastle and London) Mammalian topoisomerase II shares structural, functional and mechanistic features with DNA gyrase, the ...

S. S. Baig, 1998

DNA Replication

392 Other Functions of DNA Gyrase chapter 12: Cells maintain the superhelicity of the chromosome within rather narrow Topoisomerases limits. This homeostatic control is achieved by the antagonistic actions of gyrase and topo I.76 Some of ...

Arthur Kornberg, Tania A. Baker, 2005

Infectious Diseases in Immunocompromised Hosts

Currently, two major mechanisms have been defined: (1) alterations in the bacterial DNA gyrase, the molecular target of the quinolone action; and (2) reduction of drug accumulation in the cells.9" 10.2.3.1 Alterations in Bacterial DNA Gyrase ...

Vassil St. Georgiev, 1997

Cell and Molecular Biology of Plastids

1989); E. coli gyrase is comprised of 95 kDa gyrase B and 105 kDa gyrase A subunits (Reece and Maxwell 1991). A more recent proteomic study identified gyrase A- and B-like subunits in proteinnucleic acid particles from purified P. sativum ...

Ralph Bock, 2007

Bacterial Genomes: Physical Structure and Analysis

mutant but not in a gyrase mutant (Adams et al, 1992). However, gyrase does seem to be capable of replacing topoisomerase IV if overexpressed. Gyrase may supplement topoisomerase IV, since shifting a temperature-sensitive gyrase ...

F.J. de Bruijn, James R. Lupski, George M. Weinstock, 1998

Molecular Biology of DNA Topoisomerases and Its Application ...

DNA gyrase: structure and function. CRC Crii. Rev. Biochem MolBioL.2b. 335. 199L 4. Gellert. M.. Mizuuchi. K.. O'Dea. M. H.. and Nash. H. A.. DNA gyrase: an enzyme that introduces superhelical turus into DNA. Proc. Natl Acad. Sci. USA.. 73.

Toshiwo Andoh, Masao Oguro, Hideo Ikeda, 1992

Hyperthermophilic Enzymes

and ParE, which are homologous to GyrA and GyrB, respectively.9 However, Topo IV has no DNA gyrase activity but, as is the case with the eukaryotic enzyme, can relax both positively and negatively supercoiled DNA.10 In the absence of ...

‎2001

Links Between Recombination and Replication: Vital Roles of ...

and not (+), the true substrates for unlinking during replication. This is because the systems used to produce the stalled replication intermediates contained sufficient DNA gyrase to (?) supercoil the intermediates before or after stalling.

Proceedings of the National Academy of Sciences, 2002

Technological and Medical Implications of Metabolic Control ...

will lead to a change in DNA supercoiling, which in turn leads to a change in transcription rates of topoisomerase I and DNA gyrase genes. Thus a change in the level of DNA supercoiling in the global steady state is not only the result of the  ...

Athel Cornish-Bowden, Maria Luz Cárdenas, 2000

नवीन गोष्टी ज्यामध्ये «GYRASE» ही संज्ञा समाविष्ट आहे

खालील बातम्यातील आयटमच्या संदर्भात राष्ट्रीय आणि आंतरराष्ट्रीय पत्रकार कशाबद्दल बोलले आहेत आणि gyrase ही संज्ञा कशी वापरली आहे ते शोधा.

So You Actually Drank the Water During Your Vacation?

Like other fluoroquinolones, ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV. It is bactericidal, and active against Gram ... «MedPage Today, जून 15»

Choppy waters

The standalone company will deal with early stage antibiotics R&D including the novel gyrase inhibitor AZD0914, currently in phase II for the ... «Financial Express, जून 15»

Say it with proteins: an alphabet of crystal structures

... recognition; and for proteins with holes that enclose DNA (A, from DNA gyrase) or puncture the membrane (O, from the toxin cytolysin A). «Nature.com, मे 15»

AstraZeneca spins out early-stage R&D for antibiotic compounds

The new unnamed company will take over development of AstraZeneca's novel gyrase inhibitor AZD0914 for gonorrhoea, currently in phase ll ... «The Pharmaceutical Journal, मार्च 15»

Antibiotic linked to nerve damage

All Fluoroquinolone Antibiotics are Topoisomerase Inhibitors, which means they work by attacking DNA gyrase and topoisomerase IV on ... «KING5.com, मार्च 15»

AZ spins out antibiotics R&D biz to focus on key pipelines

The stand-alone company will exclusively deal with early-stage antibiotics R&D, including the novel gyrase inhibitor AZD0914, currently in ... «In-PharmaTechnologist.com, मार्च 15»

AstraZeneca to spin off anti-infectives research

The new company's principal asset will be the novel gyrase inhibitor AZD0914, which is currently in Phase II clinical trials for treating ... «Royal Society of Chemistry, मार्च 15»

AstraZeneca Launches $40M Early-Stage Anti-Infectives R&D Unit

The new subsidiary will focus exclusively on R&D for AstraZeneca's early-stage antibiotic pipeline, including the gyrase inhibitor AZD0914, now ... «Genetic Engineering & Biotechnology News, फेब्रुवारी 15»

Cystic Fibrosis Drug Quinsair For Pseudomonas Aeruginosa …

Specifically, the drug acts by inhibiting important bacteria enzymes for DNA replication, the bacterial DNA gyrase and topoisomerase IV ... «Cystic Fibrosis News Today, डिसेंबर 14»

Researchers discover bacteria-killer from natural source

"We were able to show that cystobactamides act as gyrase inhibitors. They prevent the DNA of the bacteria from being compacted in a ... «HealthCanal.com, डिसेंबर 14»