APAKAH MAKSUD ANTISENSE RNA dalam CORSICA?
RNA antisense
RNA antisense adalah RNA tunggal terkandas yang melengkapkan pelindung RNA messenger dalam sel. Beberapa penulis telah menggunakan istilah micRNA untuk merujuk kepada RNA ini tetapi tidak digunakan secara meluas. RNA antisense boleh diperkenalkan ke dalam sel untuk menghalang terjemahan mRNA pelengkap dengan berpasangan asas dan menghalang jentera penterjemahan secara fizikal. Oleh itu, kesan ini adalah stoikiometri. Satu contoh mekanisme antisense mRNA yang semulajadi adalah sistem hok / sok dari plasmid E. coli R1. RNA antisense telah lama dianggap sebagai teknik yang menjanjikan untuk terapi penyakit; satu-satunya kes yang telah sampai ke pasaran adalah fomivirsen dadah. Seorang pengulas telah mencirikan RNA antisense sebagai salah satu daripada "berpuluh-puluh teknologi yang cantik dalam konsep, tetapi mengecewakan dalam". Pada umumnya, RNA antisense masih kurang reka bentuk yang berkesan, aktiviti biologi, dan pentadbiran laluan yang cekap.
Definisi antisense RNA dalam kamus Corsica
Takrif RNA antisense dalam kamus adalah molekul yang ditranskripsikan, bukan dari DNA dengan cara biasa, tetapi dari helai DNA yang melengkapi kepada mereka yang menghasilkan RNA messenger biasa. RNA antisense berlaku dalam alam semula jadi dan menghalang tindakan gen. Ia boleh dihasilkan secara sintetik dan menawarkan kemungkinan terapeutik seperti mematikan gen virus.
CORSICA BUKU YANG BERKAIT DENGAN «ANTISENSE RNA»
Ketahui penggunaan
antisense RNA dalam pilihan bibliografi berikut. Buku yang berkait dengan
antisense RNA dan ekstrak ringkas dari yang sama untuk menyediakan konteks penggunaannya dalam kesusasteraan Corsica.
1
Antisense oligodeoxynucleotides and
antisense RNA: novel ...
This book is a practical, state-of-the-art treatise on antisense oligodeoxynucleotide and antisense RNA technology and the potential application of these strategies in therapeutics.
2
Gene regulation: biology of
antisense RNA and DNA
Natural antisense activities & mediators; ribozyme approach to antisense control; antisense RNA mechanisms/modifications
Robert P. Erickson, Jonathan G. Izant,
1992
It makes use of "antisense" RNA to block the expression of a gene. Increasing the
expression of a particular gene — increasing the rate at which it is "read" such
that it produces large quantities of hormone or enzyme, for example — has been
...
4
Biotechnology: Academic Cell Update Edition
In some organisms, antisense RNA is one way by which RNA controls protein
translation. Antisense RNA binds to the complementary mRNA and blocks
translation. From this discovery came the potential use of antisense RNA to block
or ...
David P. Clark, Nanette J. Pazdernik,
2011
The discovery of the natural biological function of antisense RNA was made in
1981 by Jun-ichi Tomizawa (Tomizawa et ai, 1982). In the past 5 years, this new
technology has been extensively developed. It has been applied in vitro and in ...
Louis-Marie Houdebine,
1997
6
Antisense Research and Applications
Modes of antisense RNA production from sense chs transgenes. (A) Generation
of antisense RNA due to transcription readthrough from the promoter of the nptll
antibiotic resistance gene into the chs gene. (B) Generation of antisense RNA ...
Stanley T. Crooke, Bernard Lebleu,
1993
7
Antisense Technology, Part A, General Methods, Methods of ...
[28] Antisense RNA and DNA in Escherichia coli Antisense RNA (asRNA) has
been shown to be utilized effectively in Escherichia coli as a natural regulatory
factor to control a variety of important biological processes. Among them are
plasmid ...
8
RNA Methodologies: A Laboratory Guide for Isolation and ...
Antisense RNA was also shown to regulate gene expression in mammalian
systems in vitro (Nishikura and Murray, 1987); in phages, bacteria, and plants (
Green et al., 1986); and in animals (Knecht and Loomis, 1987). Previous attempts
to ...
Robert E. Farrell, Jr.,
2010
9
Antisense Nucleic Acids and Proteins: Fundamentals and ...
In the design of efficient artificial antisense RNA control of gene expression, it
may be sufficient to engineer the antisense RNA so that it is complementary to
the translation initiation site of the target gene, thereby avoiding the need to
design ...
Joseph N. M. Mol, Alexander R. van der Krol,
1991
10
RNA Infrastructure and Networks
By employing in vitro strategies, the antisense RNA was found to silence the p15
promoter in cis or in trans and to be involved in the establishment but not in the
maintenance of silencing, which persisted even in the absence of the antisense ...
BARANGAN BERITA YANG TERMASUK TERMA «ANTISENSE RNA»
Ketahui apa yang diterbitkan oleh akhbar nasional dan antarabangsa dan cara istilah
antisense RNA digunakan dalam konteks perkara berita berikut.
Bacterial physiology Obg controls bacterial persistence
Conversely, decreasing Obg using antisense RNA significantly reduced survival, demonstrating that Obg concentration controls persistence in ... «Nature.com, Jun 15»
Strand-specific RNA sequencing in Plasmodium falciparum malaria …
Using this approach, we identified 660 intergenic lncRNA (647 unique loci), 474 antisense RNA (467 unique loci), and 1381 circRNA ... «BMC Blogs Network, Jun 15»
Arcturus, Janssen Collaborate to Commercialize RNA-Based Drugs …
... antisense RNA, microRNA and gene editing therapeutics. The company owns unlocked nucleomonomer agent (UNA) technology including ... «AZoNano.com, Jun 15»
Arcturus Therapeutics Announces Strategic Collaboration with …
... antisense RNA, microRNA and gene editing therapeutics. The company owns unlocked nucleomonomer agent (UNA) technology including ... «MarketWatch, Jun 15»
Unravelling the mystery of the most common genetic cause of motor …
“This intriguing observation suggests that antisense RNA foci may occupy a key position in the cascade of disease pathogenesis in C9ORF72 ... «University of Sheffield News, Mei 15»
Antisense RNA from C9ORF72 Repeats Is Likely Culprit in Patient …
More telling, the antisense RNA was more often accompanied by mislocalized TDP-43, a hallmark of ALS and some FTDs. “This suggests the ... «Alzforum, Mei 15»
DEGS2 polymorphism associated with cognition in schizophrenia is …
... expression of MARCKS in post-mortem brain of violent suicide completers is related to transcription of a long, noncoding, antisense RNA. «Nature.com, Apr 15»
Research and Markets: Nucleic Acid Therapies in Oncology Drug …
... Therapy, DNA vaccine, Other DNA technologies, RNA Interference (RNAi), Small interfering RNA (siRNA), Antisense RNA and Ribozymes. «Business Wire, Jan 15»
Novartis gets allies in gene editing field
... gene editing uses a protein that acts as a scissors as well as a targeting strain of antisense RNA that binds to the scissors and guides it to a ... «Boston Globe, Jan 15»
Arcturus Therapeutics Announces the Appointment of Michael R …
... antisense RNA, and microRNA oligotherapeutics. The company's UNA Oligomer™ chemistry technology and patent portfolio (34 patents, ... «PR Newswire, Dis 14»