CO OZNACZA SŁOWO AMES TEST
Test Amesa
Test Amesa jest szeroko stosowaną metodą, która wykorzystuje bakterie w celu sprawdzenia, czy dana substancja chemiczna może powodować raka. Bardziej formalnie jest to biologiczny test do oceny mutagennego potencjału związków chemicznych. Pozytywny test wskazuje, że substancja chemiczna jest mutagenna, a zatem może działać jako rakotwórcza, ponieważ rak jest często związany z mutacją. Test służy jako szybki i wygodny test w celu oszacowania rakotwórczego potencjału związku, ponieważ standardowe próby rakotwórcze u myszy i szczurów są czasochłonne i kosztowne. Jednak fałszywie dodatnie i fałszywie negatywne są znane. Procedura została opisana w serii dokumentów na początku lat 70. przez Bruce Amesa i jego grupę na Uniwersytecie Kalifornijskim w Berkeley.
Definicja słowa Ames test w słowniku
Definicja testu Amesa w słowniku jest metodą wstępnego badania przesiewowego czynników rakotwórczych, opartą na ich zdolności do wywoływania mutacji w bakteriach.
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1
Molecular Biology: Genes to Proteins
Although other tests also have been developed to detect mutagens and
carcinogens, the Ames test remains the most widely used. The Ames test has
now been used with tens of thousands of substances and mixtures (such as
industrial ...
2 days ,—1 incubation \S at 37°C Colonies of mutant bacteria Diagram showing
the simple steps in the Ames test for mutagens understood. Basically though they
are planar molecules which can slip between the "stacked" nucleotide bases in ...
Ames Test A test for determining if a chemical is a mutagen. Named for its
developer, Bruce Ames. The use of the Ames test is based on the assumption
that any substance that is mutagenic (for the bacteria used in his test) may also
turn out to ...
Some mutagens are positive in the Ames test even in the absence of S9; certainly
, DNA-reactive alkylating agents such as Af-ethyl- N-nitrosourea (ENU; see
chapter 15) fall into this class. Such compounds are often called "direct-acting" ...
P. David Josephy, Bengt Mannervik,
2006
5
Principles of Environmental Toxicology
5.2.4.1 The Ames Test Bruce Ames is an American scientist who has been
working on carcinogenicity for many years. He devised a test that utilises a
mutant of the bacterium Salmonella typhimurium which is unable to synthesise its
own ...
I. Shaw, J. Chadwick,
1998
6
Quality Assurance for Environmental Measurements: A Symposium
Llewellyn R. Williams1 Quality Assurance Considerations in Conducting the
Ames Test REFERENCE: Williams, L. R., "Quality Assurance Considerations in
Conducting the Ames Test," Quality Assurance for Environmental Measurements,
...
John Keenan Taylor, Thomas W. Stanley,
1985
7
Carcinogenicity: Testing: Predicting, and Interpreting ...
As stated in the introduction, few tests have been found to complement the Ames
test, the most widely used CST. In our earlier study of kc complementing the
Ames test and SAs, 107 chemicals classified as rodent carcinogens by the NCI/
NTP ...
8
Ozone in Water Treatment: Application and Engineering
Ames test (Salmonella back-mutation assay). The Ames test is based on the use
of mutants of Salmonella typhimurium that are deficient in the histidine operon. A
reverse mutation, resulting from the effect of some mutagenic agent, enables the
...
Am Water Works Res F, Bruno Langlais, David A. Reckhow,
1991
9
Optimization in Drug Discovery: In Vitro Methods
When using a crude human liver S9 fraction, which is obtained following the
centrifugation of the tissue homogenate for 20 min at 9000g, in the Ames test, we
may sometimes find contaminating bacterial colonies and/or an increasing
number ...
Zhengyin Yan, Gary Caldwell,
2004
10
Toxicological Chemistry and Biochemistry, Third Edition
8.4.2 The Bruce Ames Test and Related Tests The most widely used test for
mutagenicity is the Bruce Ames test, named after the biochemist who developed
it. A number of variations and improvements of this test have evolved since it was
first ...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «AMES TEST»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
Ames test w wiadomościach.
FDA Regulation of Adhesives in Food Packaging
For low dietary intakes of up to 50 ppb, this means submitting reports of in vitro genotoxicity assays, such as an Ames test and mouse lymphoma or chromosome ... «Food Safety Magazine, Cze 15»
Baldwin School senior Jasmine Syed is Main Line Student of the Week
My project was called “Mutagenesis of Diesel and Biodiesel” and for the project I used the Ames test to see if diesel exhaust or biodiesel ... «Main Line, Maj 15»
Bad Medicine? New Disposal Option
... waste was subjected to a battery of tests including corrosiveness, reactivity, acute toxicity LD50, leachate eco-toxicity, and mutagenicity assay (Ames test). «Waste Management World, Lut 15»
JRC launches genotoxic and carcinogenic chemicals database
The European Commission's Joint Research Centre (JRC) has launched a database of chemicals testing positive in the Ames test – a ... «Chemical Watch, Gru 14»
Styrene oligomers extracted from food contact plastic not genotoxic
... oligomers from food-grade plastic and then used this to prepare samples for use at a range of doses in the Ames test – a bacterial in vitro test ... «Chemical Watch, Lis 14»
The REACH data market: a major players' view
At present, the Qsar model is able to predict the data for three specific endpoints: bacterial reverse mutation assay (in particular the Ames test), acute fish toxicity; ... «Chemical Watch, Paz 14»
Investigating the genotoxicity of iron oxide nanoparticles
... surface coatings are assessed using three standard genotoxicity assays: the Salmonella typhimurium reverse mutation assay (Ames test), the ... «nanotechweb.org, Paz 14»
Life is about Moderation
His name is Dr. Bruce Ames, and his test, the Ames Test, is still used to determine if chemicals can cause cancer. It was his test that determined ... «KING5.com, Wrz 14»
Ames test successfully adapted for use with cigarette smoke and …
The Ames test, a widely used method to determine whether a chemical has the potential to cause cancer, has been successfully adapted for ... «News-Medical.net, Sie 14»
Ames test adapted successfully to screen complex aerosols
The Ames test, a widely used method to determine whether a chemical has the potential to cause cancer, has been successfully adapted for ... «EurekAlert, Sie 14»