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1
BCL‑2 Protein Family: Essential Regulators of Cell Death
As critical control points of the intrinsic apoptotic pathway, the BCL-2 family of cell
death regulators plays an important role in cellular homeostasis.1-3 The different
anti- and pro-apoptotic members of this family form a highly selective network ...
2
The Roles of the Anti-apoptotic Proteins
Bcl-2 and Mcl-1 in ...
The requirement for Bcl-2 in lymphoid cell development 5.1 Bcl-21' LckCre mice
Bcl-2"'" Bcl-2lox LckCre mice (herein referred to as Bcl-2"7" LckCre) were
generated, but our PCR screening strategy did not allow us to distinguish
between ...
Ivan Lilyanov Dzhagalov, 2007
3
BCL-2 Genotypes and Outcomes After Traumatic Brain Injury
Table 2-2: Bcl-2 and Traumatic Brain Injury in Humans: Literature Review Table 2
-2 continued. 53. Bcl-2 and Traumatic Brain Injury in Humans: Literature Review
1960-2008 Population Subjects (n) Severity of Injury Tissue Analyzed ...
Nicole Zangrilli Hoh, 2008
4
Rational Design, Synthesis, and Biological Evaluation of ...
The most potent candidate, 3g, exhibited more than a 3-fold increase in the
binding affinity to the three anti-apoptotic Bcl-2 proteins and greater than a 13-
fold increase of in vitro cytotoxicity among the four tumor cell lines tested. HA 14-
1 and ...
The 25kD form of Bcl-2, termed Bcl-2a, is encoded by a 6 kb mRNA and
represents the predominant bcl-2 gene product (Cleary et al., 1986; Tsujimoto
and Croce, 1986). An additional Bcl-2 isoform, Bcl-26, is generated by an
alternatively ...
James W. Wilson, Catherine Booth, C. S. Potten, 1998
6
Vascular Endothelial Growth Factor (VEGF),
BCL-2, and Bax ...
But ultimately what determines whether a cell lives or dies is now known to be a
balance between apoptotic and survival pathways, specifically pathways
involving proteins of the BCL-2 family (Tang and Kehrer 2007). Members of this
BCL-2 ...
Angela Bancalari-Schmidlapp, 2009
7
Apoptotic Pathways as Targets for Novel Therapies in Cancer ...
In an initial computer-assisted screen based on the 3D structure of Bcl-2, 35
compounds were identified. The compounds were subsequently tested in in vitro
FP-based Bcl-2 binding assays and 7 were found to disrupt Bak BH3 peptide/Bcl-
2 ...
Marek Los, Spencer B. Gibson, 2006
histotypes.17-19 Using bcl-2 overexpressing clones, obtained after transfection
of breast MCF7 ADR, melanoma M14 and prostate carcinoma PC3, LNCaP, and
DU-145 cell lines, it was found that bcl-2 overexpression substantially increases
...
9
Bcl-2 Family Members PUMA, Noxa and Mcl-1, in P53 Mediated ...
Involvement of Bcl-2 family proteins has been implicated in neuronal survival, injury and a number of neurodegenerative disorders.
10
Paradoxical Effects of Bax and
Bcl-2 on Oncogenesis
The primary function of the Bcl-2 family is to regulate apoptosis; however,
numerous studies have shown that members of this family have paradoxical
effects on cancer. As mentioned in the introduction, several studies have
ascribed these ...
Christopher van de Wetering, 2007
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «BCL»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
BCL w wiadomościach.
BCL Refurbishes Smelter
Selibe Phikwe — The BCL Mine smelter has been shutdown to modernise and upgrade it to run for a longer service campaign. «AllAfrica.com, Lip 15»
Titumir college BCL men go on rampage
A college student said Sunny, a BCL college unit member, had been beaten by supporters of Delwar, president of the local Awami League ... «DhakaTribune, Lip 15»
AL leader dies after being injured by BCL activists in Comilla
An Awami League leader, who was allegedly hacked by a group of Bangladesh Chhatra League (BCL) activists in Monohorganj upazila of ... «Financial Express Bangladesh, Lip 15»
BCL Gives Media Insight
Selibe Phikwe — BCL Mine divisional manager- organisational capability, Mr Motsile Sibanda, says the media plays an important role of ... «AllAfrica.com, Lip 15»
15 injured in BCL attack
An attack for extortion by Bangladesh Chhatra League (BCL) activists on a student-mess adjacent to the Government Michael Madhusudan ... «DhakaTribune, Lip 15»
RU students protest 'cop torture' on BCL leader
Kazi Aminul Islam Lingcon, in his fourth year and also Bangladesh Chhatra League's (BCL) RU unit sports secretary, claimed he was beaten ... «The Daily Star, Lip 15»
BCL injects additional P53m into Pula Steel
FRANCISTOWN: BCL has injected a further P53 million to support the construction of its subsidiary, Pula Steel Manufacturing and Casting ... «Mmegi Online, Cze 15»
Cops 'torture' RU BCL leader
Kazi Aminul Islam Lingcon, the BCL sports secretary at RU and a fourth-year student of marketing, was admitted to Rajshahi Medical College ... «The Daily Star, Cze 15»
Teachers-BCL men faceoff makes SUST unstable
Then, a group of BCL men gathered there and chanted slogans against the agitating teachers which created panic among general students. «DhakaTribune, Cze 15»
BCL's polaris 11 strategy begins to bear fruit
SELEBI-PHIKWE: The Polaris 11 strategy that BCL Mine adopted two years ago to transform the company into a diversified enterprise is ... «Mmegi Online, Cze 15»
