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1
Structure and Regulation of Aspartate Pathway Enzymes and ...
MALDI mass spectrometry, carried out by the proteome mapping service at the
University of Michigan, was used to determine the deuteration level of d-XaDHL,
which had been back exchanged with deuterated medium after purification in ...
2
Modern Techniques in Protein NMR: Volume 16: Modern ...
Practically, this is accomplished by perdeuterative isotopic labeling (Venters et ai,
1995a; LeMaster, 1994). In this technique, one perdeuterates all
nonexchangeable sites in a protein. 1.2. Deuteration 1.2.1. History of Deuteration
Since the ...
N. Rama Krishna, Lawrence Berliner, 1998
Ratios of Rates of Exchange and Deuteration. There is great variation in this ratio
with the different metals. The ratio is high on nickel films in agreement with the
results of Horiuti, Ogden, and Polanyi (1), who found a ratio of 90 over nickel foil.
D. D. Eley, W. G. Frankenburg, Vasili Ilyich Komarewsky, 1957
4
Assignment of Vibrational Modes to the Bands of the Raman ...
riboflavin binding protein (RBP), 31, 78 is observed in the D2O spectrum and
shifts to 1260 cm-1 upon 8-CH3-deuteration. Since no Raman band in H2O has
such a large sensitivity to 8-methyl deuteration, the origin of the 1274 cm-1 band
...
5
KDP - Family Single Crystals
7.7.7 Hydrogen isotope exchange equilibrium The influence of the solution
deuteration degree, x,, on the deuteration degree of crystals, xs, in equilibrium
with the solution has not been studied extensively. It is known that the deuteration
...
6
The Dense Interstellar Medium in Galaxies: Proceedings of ...
In practice, whether the deuteration is a gas phase or active grain chemistry
product, the large observed deuteration ratios cannot be reproduced if not in
extreme conditions: the gas must be very dense, cold and severely depleted of
CO.
7
Protein NMR Spectroscopy: Practical Techniques and Applications
This approach was applied for the relaxation study of thioredoxin, with the
concomitant use of 50 % random fractional deuteration. A notable example of this
isotope labelling strategy was the structure determination of an SH3 domain by ...
Gordon Roberts, Lu-Yun Lian, 2011
8
Neutron Scattering for the Analysis of Biological ...
What we will document below is that the extent of deuteration of different species
of macromolecules produced by bacteria may differ significantly under such
growth conditions. Furthermore, the extent of deuteration of a given
macromolecular ...
Benno P. Schoenborn, 1976
9
Linking Protein Dynamics to Protein Function
The average fractional deuteration was calculated for B. stearo DHFR peptides at
10 °C and 55 °C and 10 sec and 300 min. The change in the average fractional
deuteration was less than 2 fold between the lowest and highest temperature ...
Olayinka Aduke Oyeyemi, 2008
10
Multifunctional Conducting Molecular Materials
dependence analysis on single crystal X-ray measurements for pristine and
deuterated salts to understand the deuteration effects on the crystal structure.
One possible reason for the enhancement of Tco with deuteration is a chemical ...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «DEUTERATION»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
deuteration w wiadomościach.
Concert Pharmaceuticals' precision deuteration platform can …
Substituting deuterium for certain hydrogen atoms in molecules has been shown to enhance the metabolic properties of a number of drugs and ... «News-Medical.net, Lip 15»
Alzheimer's disease markers could be identified through protein …
Protein deuteration was used to largely mask the neutron scattering signal of the proteins themselves, and focus instead on the signal from the ... «Medical Xpress, Kwi 15»
Deuterated drugs Relief from racemization
Racemization occurs by exchange at this stereocentre and deuteration slows the process — as would be expected from a primary kinetic ... «Nature.com, Kwi 15»
Teva acquires Auspex for $3.5 billion, increases patent holdings in …
Deuteration which can reduce the negative health impacts caused by tetrabenazine use and drug interactions would also be protected by U.S. ... «IPWatchdog.com, Kwi 15»
Teva buying Auspex for $3.2 billion
Auspex uses a chemical process called deuteration - adding a heavier isotope - to a known drug compound, to improve the safety and efficacy ... «Philly.com, Mar 15»
Concert Pharmaceuticals' (CNCE) CEO Roger Tung on Q4 2014 …
Secondly, deuteration tends to impact metabolism rate, as I understand that. I guess what I would really like to know is whether or not you would ... «Seeking Alpha, Lut 15»
Speculating on Achillion's Boom-or-Bust Hep C Drug Study Results
$ACHN deuteration strategy: Shooting from him, a little disappointing. Likely novel, but may get Paragraph 4'd for obviousness. — John Alan ... «TheStreet.com, Paz 14»
High-Tech with DLaTGS
This is achieved by the process of deuteration, the complete replacement of all hydrogen atoms by deuterium atoms. Additional doping with ... «Optics.org, Paz 14»
Team discovers unexpected effect of heavy hydrogen in organic …
“Normally scientists assume that the deuteration doesn't change the electronic structure at all,” said Xiao, a materials scientist at ORNL's Center ... «R & D Magazine, Mar 14»
An Introduction into the Role of Gas Chromatography - Mass …
The degree of deuteration must be sufficient to allow the deuterated molecular ions to be resolved from those of the natural isotope. Assuming ... «Chromatography Today, Lut 14»
