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1
Handbook of Mouse Mutations with Skin and Hair ...
Common Uses of the Downless Mutation 245 VIII. Availability of Mice 245
References 245 I. HISTORY The downless mutation (dl) arose spontaneously in
the late 1950s on the A/H strain.12 It closely resembled the crinkled (cr) mutation;
...
Roger Daudin of Poitiers, France, called in a doctor. He said nothing could be
done (it was hereditary), so Madame remarked at least she wouldn't have to
pluck this bird. But one chilly night the downless drake gave up, lay down and
became ...
3
Death Receptors in Cancer Therapy
ROLE OF EDAR IN THE PATHOGENESIS OF AUTOSOMAL FORMS OF HEDS
As discussed above, downless, sleek, and crinkled mice have phenotypes similar
to Tabby and represent the counterparts of autosomal forms of human HEDs.
4
Mouse Development: Patterning, Morphogenesis, and Organogenesis
The exact physical role of the EK is not yet established but changes in its
morphology in tooth germs of spontaneous mouse mutants with abnormal molar
cusp formation such as Tabby (Eda) and downless (d1) have started to reveal
some ...
Janet Rossant, Patrick T. Tam,
2002
5
Inborn Errors of Development: The Molecular Basis of ...
Another spontaneous mouse mutation, Downless, encodes Edar, a novel
member of the TNF receptor family containing the characteristic extracellular
cysteine-rich fold, a single transmembrane region, and a death homology domain
(Headon ...
Charles J. Epstein, Robert P. Erickson, Anthony Joseph Wynshaw-Boris,
2004
6
Studies in Stomatology and Craniofacial Biology
Downless,. and. Sleek. Falconer et al. [1951] reported the occurrence of a mutant
mouse, showing abnormal features, the most obvious of which were: an
abnormal texture of the coat, a bald patch behind each ear, a kink at the tip of the
tail, ...
M. Cohen, Meyer Michael Cohen, B. Baum,
1997
7
Hair Growth and Disorders
6.2.1.2 Experimental Techniques Three spontaneous mouse mutants (sleek,
downless, and crinkled) have been known to display identical pheno- types with
the Tabby mouse. Recent studies have shown that Sleek and downless have, ...
Ulrike Blume-Peytavi, David A. Whiting, Ralph M. Trüeb,
2008
8
Annual Scientific Report
Two of the transgenic families under study {downless and symplastic spermatids)
have developmental abnormalities caused by insertional mutations. For both of
these families, genomic sequences flanking the transgenic inserts have been ...
Howard Hughes Medical Institute,
1989
En:en. tabby and downless mutant mice have apparently identical defects In
teeth, hair and sweat glands. Recently, genes responsible for these spontaneous
mutations have been Identified, downless (Or) encodes Edar. a novel member of
...
10
Genetically Engineered Mice Handbook
Two other phenotypic mutants, downless (ectodysplasin-A receptor, Edcrdl) and
crinkled (ectodysplasin-A receptor-associated death domain, Edaradd"), are
available and their mutant gene loci map to distinct chromosomes. Tabby has
now ...
John P. Sundberg, Tsutomu Ichiki,
2005