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1
Efflux Transporters and the Blood-brain Barrier
The goal of this book is to provide readers with a comprehensive review of the state-of-the-art of efflux transport across the blood-brain barrier and to provide detailed 'food-for-thought' which will hopefully stimulate more research in ...
2
Cholesterol
Efflux in Adipose Tissue
Cholesterol. efflux. and. apoA-I. recycling. in. macrophages. Introduction Reverse
Cholesterol Transport (RCT) is relevant because peripheral cells acquire
cholesterol through uptake of lipoproteins and de novo synthesis, but are unable
to ...
Philip Benjamin Verghese, 2007
3
Microbial
Efflux Pumps: Current Research
Site-directed mutagenesis reveals putative substrate binding residues in the
Escherichia coli RND efflux pump AcrB. J. Bacteriol. 190, 8225– 8229.
Brandstätter et al. (2011). Analysis of AcrB and AcrB/ DARPin ligand complexes
by LILBID MS.
Edward W. Yu, Qijing Zhang, Melissa H. Brown, 2013
4
Drug Discovery and Evaluation: Safety and Pharmacokinetic ...
(2001) Correlation of gene expression of ten drug efflux proteins of the ATP-
binding cassette transporter family in normal human jejunum
andinhumanintestinalCACO-2cellmonolayers. J Pharmacol Exp Ther 299:164–
170 EXAMPLE ...
5
Pharmaceutical Profiling in Drug Discovery for Lead Selection
Ronald Borchardt, Edward Kerns, Christopher Lipinski, Dhrien Thakker, Binghe
Wang. be robust and timely, and require low resource. Cell-based assays
suitable at this stage include monolayer efflux, cell uptake, and isolated tissue
assays.
Ronald Borchardt, Edward Kerns, Christopher Lipinski, 2005
6
Interplay Between P-glycoprotein-mediated
Efflux and ...
The percent of dose metabolized (or rate of metabolism) seems like a more
relevant value for quantifying this interaction, since the effect of P-gp efflux on
absorption is not incorporated into this parameter. Although Model A produced
some ...
7
Mechanism of Multi-drug
Efflux by AcrB and MexB Subfamily of ...
CHAPTER ONE Mutations that enable functional alignment between components
of tripartite multi-drug efflux complexes: Fitting Escherichia coli AcrA with
Pseudomonas aeruginosa MexB. 1.1 ABSTRACT AcrAB-TolC and MexAB-OprM
are ...
Ganesh Krishnamoorthy, 2008
8
Antimicrobial Drug Resistance: Mechanisms of Drug ...
Cytoplasmic membrane- localized efflux pumps are widespread among bacteria
and are divided into five major classes on the basis of bioener- getic and
structural criteria (64) and it is worth noting that in addition to contributing to
antibiotic ...
9
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery
One of the primary values to the in vitro LLC-PK1 transwell bidirectional transport
assay is the potential to generate sufficient information within a structural series
to establish chemical strategies to overcome Pgp efflux. The demonstration of a ...
Ronald Borchardt, Edward Kerns, Michael Hageman, 2007
10
Drug-Drug Interactions, Second Edition
Experimental Methods Used with Tissue Culture Transport Models to Study P-gp
Efflux The use of appropriate experimental design can provide definitive
evidence that P-gp-mediated efflux is altering the transport of a compound and
can ...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «EFFLUX»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
efflux w wiadomościach.
Canadians cleaning Israel's infamous Kishon riverbed: Authorities …
In the Kishon River, near Haifa: Pollution from efflux of power station. Photo by Itzik Ben-Malki. Text size. Comments (0). Print Page. Send to ... «Haaretz, Lip 15»
Genomic potential for arsenic efflux and methylation varies among …
To mediate accidental arsenate uptake, some Prochlorococcus isolates contain genes encoding a full or partial efflux detoxification pathway, ... «Nature.com, Lip 15»
Argon blocks the expression of locomotor sensitization to …
The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of β2 subunit-containing ... «Nature.com, Lip 15»
In CF, Can Playing a Sport or Biking Mean Less Time in the Hospital …
The study observed that “at least in the short term, moderate exercise can provide similar benefits for mediating Cl- efflux as their standard ... «Cystic Fibrosis News Today, Lip 15»
Week aboard Mystic Whaler teaches river program
He continued, “ Walt Whitman writes that 'the efflux of the soul is happiness.' While Whitman also writes that happiness 'pervades the open air, ... «Poughkeepsie Journal, Lip 15»
A β-lactamase inhibitor revival provides new hope for old antibiotics
Merck's DABCO relebactam adds a piperidine ring, which Merck principal scientist Katherine Young says helps prevent efflux out of the ... «Nature.com, Lip 15»
Drug resistance patterns of Mycobacterium tuberculosis complex …
Other mechanisms like efflux pumps have their own contribution in drug resistant TB [11]. In the current study, place of residence, duration of ... «BMC Blogs Network, Lip 15»
Uganda is still hostage to the past
Low pay isn't an absolute justification for this efflux because sources in the diaspora say some settle for more squalid odd jobs and working ... «New Vision, Lip 15»
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin …
PHT pharmacokinetic variability has also been related to the activity of P-glycoprotein, an efflux pump of the ATP-binding cassette family ... «Nature.com, Cze 15»
Novel Oral Anticoagulants
The efflux transporter permeability glycoprotein 1, or P-gp, is a protein found on the surface of epithelial cells in the kidneys, liver, and small ... «Pharmacy Practice News, Cze 15»
