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Ovarian Cancer: State of the Art and Future Directions in ...
Most studies to date have focused on candidate gene approaches to identify
epigenetically regulated genes in ovarian cancer, in particular, methylated and
silenced candidate tumor suppressor genes. Selected targets include genes with
...
George Coukos, Andrew Berchuck, Robert Ozols, 2008
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Epigenetic Alterations in Oncogenesis
In addition to being epigenetically regulated, like PCG, miRNAs can also affect
the expression of epigenetically regulated genes by targeting key enzymes
responsible for epigenetic reactions. We call this group of miRNAs, epi-miRNAs.
DNMT-and HDAC inhibitors Indirect angiostatic effects by reactivation of
epigenetically silenced angiogenesis-inhibiting tumor suppressor genes in tumor
cells Epidermal growth factor (EGF) Hepatocyte growth factor (HGF) Insulin
growth.
Extensive work has been conducted to study the role of epigenetically silenced
genes in HB, mainly focusing on genes known to be involved in the
developmental signaling pathways and apoptosis (Eichenmuller et al. 2009;
Harada et al.
Arthur Zimmermann, Marcio Malogolowkin, Giorgio Perilongo, 2011
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Prostate Cancer: New Insights for the Healthcare ...
Our aim was to identify epigenetically dysregulated genes in prostate cancer,”
researchers in Tampere, Finland report. “We performed miRNA expression
profiling after relieving epigenetic modifications in 6 prostate cancer cell lines
and ...
6
Epigenetic Regulation in the Nervous System: Basic ...
Within a single neuron, the tagged paternal allele of the BDNF gene might be
used exclusively during development, and epigenetically regulated as
appropriate for its role during early life. The maternal BDNF allele might then be
reserved for ...
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, 2012
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Environmental Epigenomics in Health and Disease: Epigenetics ...
Epigenetics and Disease Origins Randy L Jirtle, Frederick L. Tyson.
Epigenetically labile genes particularly vulnerable to environmentally induced
epigenetic dysregulation include those that are imprinted or have metastable
epialleles.
Randy L Jirtle, Frederick L. Tyson, 2013
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Genome Organization And Function In The Cell Nucleus
8.3.2 Epigenetically Marked Chromatin Interactions Some NETs specifically bind
heterochromatin proteins. In addition to core histones, LBR also binds HP1a and
HP1g [57]. Either through this interaction or in addition to this interaction LBR ...
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Integration/Interaction of Oncologic Growth
molecule, upregulated constitutively in the aggressive melanoma cells, was
epigenetically induced in the poorly aggressive MUM-2C cells exposed to the
MUM-2B-preconditioned matrix microenvironment. This adhesion molecule, also
...
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Cancer: New Insights for the Healthcare Professional: 2011 ...
epigenetically. modulating. Bim. expression. Data detailed in 'Polycomb protein
EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating
Bim expression' have been presented. “Deregulation of the pRB/ E2F pathway, ...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «EPIGENETICALLY»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
epigenetically w wiadomościach.
Epizyme Announces Extension of Celgene Research Collaboration
... potential to help many patients with epigenetically driven cancers,” said Robert Gould, Ph.D., President and Chief Executive Officer, Epizyme. «Business Wire, Lip 15»
Epigenetic activities of flavonoids in the prevention and treatment of …
Thus, a growing number of epigenetically active compounds are currently tested in clinical trials for their therapeutic potential. Interestingly ... «7thSpace Interactive, Lip 15»
Public Release: 6-Jul-2015 Epigenetic driver of glioblastoma …
"For instance, glioblastomas can escape the killing effects of a drug targeting MYC by simply shutting it off epigenetically and turning it on after ... «EurekAlert, Lip 15»
Are DSM Psychiatric Disorders “Heritable”?
Recent findings that gene expression switches on and off “epigenetically” in response to environmental events and challenges provide ... «Mad In America, Cze 15»
Epigenetic therapy overcomes treatment resistance in T cell …
We also report epigenetically induced expression of the surface receptor protein CD30 in T-PLL. Subsequent treatment with the anti-CD30 antibody–drug ... «Science Magazine, Cze 15»
Genetics: No more addictive personality
Kenny's lab studies these as well and found that one way that addiction can epigenetically 'rewire' the brain is by turning on genes that are ... «Nature.com, Cze 15»
Oxidized DNA Base is Stable Part of Mammalian Genome
The Cambridge scientists believe that 5fC might be acting epigenetically to alter the way DNA is recognized for gene expression. “Unmodified ... «Genetic Engineering & Biotechnology News, Cze 15»
Integrin α1β1 expression is controlled by c-MYC in colorectal cancer …
This treatment did not trigger ITGA1 expression as compared with dimethyl sulfoxide alone, whereas IGFBP7, known to be epigenetically ... «Nature.com, Cze 15»
Public Release: 15-Jun-2015 Mount Sinai scientists develop new …
... considered homogeneous using conventional techniques has epigenetically distinct subpopulations with different gene expression patterns' ... «EurekAlert, Cze 15»
Epigenetics and Its Major Influence on Life
These studies clearly illustrate that our thoughts and feelings are epigenetically much more powerful than we often realize. In order for cells to ... «Brain Blogger, Cze 15»
