KSIĄŻKI POWIĄZANE ZE SŁOWEM «PACLITAXEL»
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1
Glioblastoma:: Molecular Mechanisms of Pathogenesis and ...
The sensitivity of four human (U87MG, U373MG, H80, and D324) and two rat (9L
and F98) brain tumor cell lines to paclitaxel was evaluated (Cahan et al. 1994).
Paclitaxel in a time-dependent way showed more sensitivity to human cell lines ...
2
The Chemistry and Pharmacology of Taxol® and its Derivatives
total urinary excretion of paclitaxel. In plasma, the maximal concentrations were
observed at the end of the infusion period, reaching 2.3-6.0 ttM for paclitaxel and
0.11 uM for 7-epi-paclitaxel. Thus, the plasma concentration of 7-epi-paclitaxel ...
H. Timmerman, V. Farina, 1995
3
Current Pharmaceutical Design
analyzed [46]. IC50 (50% inhibitory concentrations) values of these two taxoids
are in the nanomolar range. Docetaxel generally is two to four fold more cytotoxic
than paclitaxel. The sensitivity profile of the cell lines, which is based on the IC50
...
4
Macromolecular Anticancer Therapeutics
Of various paclitaxel prodrugs including that of polymeric and other types of
modified forms, the lipid conjugates of paclitaxel received greater attention due to
the better ability of lipid macromolecules to penetrate the cell membranes and
also ...
L. Harivardhan Reddy, Patrick Couvreur, 2010
5
The Combination of Nab-
paclitaxel and Bevacizumab Therapy ...
Unlike other mitotic inhibitors, paclitaxel has a specific binding site on the
microtubules and it promotes the microtubules polymerization without additional
125 cofactors 124. Paclitaxel is very hydrophobic and its administration requires
the use ...
6
Cancer Chemotherapy and Biotherapy: Principles and Practice
accumulation of paclitaxel molecules in tumor and normal tissue via SPARC.
389,390 In another report of a randomized cross-over pharmacokinetic study of
PBPPI (260 mg/m2 over 30 minutes) and paclitaxel formulated in
polyoxyethylated ...
Bruce A. Chabner, Dan L. Longo, 2011
7
Medicinal Chemistry of Bioactive Natural Products
3.5 DESIGN, SYNTHESIS, AND PHARMACOLOGICAL ACTIVITY OF
PRODRUGS OF PACLITAXEL Currently the paclitaxel formulation contains a
surfactant, Cremophor EL, to improve the poor water solubility of the drug. Some
adverse ...
Xiao-Tian Liang, Wei-Shuo Fang, 2006
8
Investigation of the Effects of Alpha-TEA, ...
By far the most environmentally sensitive process is the one that the majority of
paclitaxel production today uses. Plant cell fermentation (PCF) technology,
involves using calluses of a specific taxus cell line that are then propagated in
aqueous ...
9
Cancer Management in Man: Chemotherapy, Biological Therapy, ...
AbraxaneTM (nanoparticle albumin-bound paclitaxel, nab-paclitaxel), the most
recently approved form of the taxane compounds, is an albumin-coated
formulation of paclitaxel. In order to eliminate the need for the solvents required
to increase ...
Paclitaxel and related taxanes have received considerable attention because of
their potential antitumor activity against a variety of tumors, e.g. breast cancer,
ovarian cancer, AIDS-related Kaposi's sarcoma, and non-small cell lung cancer [
2].
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «PACLITAXEL»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
paclitaxel w wiadomościach.
CTI BioPharma Corp EVP Jack W. Singer Sells 15000 Shares (CTIC)
... a biologically-enhanced chemotherapeutic agent that links paclitaxel to a biodegradable polyglutamate polymer, resulting in a new chemical ... «The Legacy, Lip 15»
Adding Onartuzumab to Triple-Negative Breast Cancer Treatment …
The addition of onartuzumab to paclitaxel with or without bevacizumab did not provide clinical benefit to patients with predominantly ... «Cancer Therapy Advisor, Lip 15»
Mayo Clinic researchers study HDAC inhibitors to find effective …
In testing multiple HDAC inhibitors in combination with the chemotherapy drug paclitaxel, known to give some benefit for this aggressive cancer ... «News-Medical.net, Lip 15»
Researchers decode molecular action of combination therapy for …
In testing multiple HDAC inhibitors in combination with the chemotherapy drug paclitaxel, known to give some benefit for this aggressive cancer ... «Medical Xpress, Lip 15»
Neratinib in HER2-Positive Breast Cancer
The phase II NEfERTT trial evaluated neratinib and paclitaxel versus trastuzumab and paclitaxel as first-line treatment in individuals with ... «OncLive, Lip 15»
Failure to Follow Weight-Based Chemo Guidelines Lowers Survival …
Compared with women of normal weight, obese women received less paclitaxel and carboplatin per kilogram of body weight and lower dose ... «OncLive, Lip 15»
Researcher invents chemo delivery system that minimizes impact on …
More information: "Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for ... «Medical Xpress, Lip 15»
Cerulean Commences Dosing in CRLX101-Weekly Paclitaxel …
Paclitaxel, a widely used chemotherapy used as subsequent therapy for the treatment of advanced ovarian cancer, has anti-angiogenic ... «AZoNano.com, Lip 15»
Cerulean doses first patient in Phase Ib trial of CRLX101-paclitaxel …
Paclitaxel has anti-angiogenic properties which can induce hypoxic conditions, leading to the up-regulation of hypoxia inducible factor 1a, ... «Pharmaceutical Business Review, Lip 15»
Holston Valley Physician Co-authors Article in New England Journal …
This study was called the Lutonix Paclitaxel-Coated Balloon for the Prevention of Femoropopliteal Restenosis 2 trial. The authors concluded ... «Kingsport Times News, Lip 15»
