CO OZNACZA SŁOWO PENTYLENETETRAZOL
Pentylenetetrazol
Pentylenetetrazol, znany również jako pentylenetetrazol, metrazol, pentetrazol, pentametylenetetrazol, Cardiazol lub PTZ, był lekiem stosowanym jako środek wspomagający krążenie i oddychanie. Wysokie dawki powodują drgawki, które odkryto w 1934 roku przez węgiersko-amerykańskiego neurologa i psychiatrę Ladislasa J. Meduna. Stosowano go w terapii konwulsyjnej, ale nigdy nie uważano za skuteczną, a skutki uboczne, takie jak drgawki, były trudne do uniknięcia. Jego zatwierdzenie przez FDA zostało uchylone w 1982 roku.
Definicja słowa pentylenetetrazol w słowniku
Definicja pentylenotetrazolu w słowniku jest białą, krystaliczną, rozpuszczalną w wodzie substancją o gorzkim smaku, stosowaną w medycynie do stymulacji ośrodkowego układu nerwowego. Wzór: C6H10N4.
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1
Idiopathic Generalized Epilepsies: Clinical, Experimental ...
pentylenetetrazol,. bicuculline. and. flurothyl. S.L. Moshe*1*, L. Velisekn and G.L.
Holmes8 Departments of 'Neurology, fNeuroscience and * Paediatrics,
Laboratory of Developmental Epilepsy, and Monte- fiore/Einstein Epilepsy
Management ...
2
Models of Seizures and Epilepsy
Low doses of AMPA exert anticonvulsant effects on pentylenetetrazol-kindled
seizures. Pharmacol Biochem Behav 70: 421–426. Becker, A., Braun, H.,
Schroder, H., Grecksch, G., and Hollt, V. 1999. Effects of enadoline on the
development of ...
Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé,
2005
Whereas the electrical kindling is regarded as a model of complex partial
epilepsy, ',2'3 the chemical kindling6,7 is a model of primary generalized
epilepsy. s Although pentylenetetrazol (PTZ) kindling has often been used to
explore the ...
Michael E. Corcoran, Solomon Moshe,
2007
4
ANNUAL REPORTS IN MED CHEMISTRY V15 PPR
Anxiety—Provoking Action of Pentylenetetrazol as IDS - Pentylenetetrazol
induced IDS was originally investigated to develop a laboratory model of a
preconvulsive neuronal excitation (aura). But, as the work progressed, it became
evident that ...
H. J. Hess, Leslie Humber,
1980
5
Drugs for the Control of Epilepsy
Mason, C. R. and Cooper, R. M., A permanent change in convulsive threshold in
normal and braindamaged rats with repeated small doses of pentylenetetrazol.
Epilepsia, 13, 663, 1972. 101 . Pinel, J. P. J. and Cheung, K. F., Controlled ...
Carl L. Faingold, Gerhard H. Fromm,
1991
6
Advanced Therapy in Epilepsy
Because a number of drugs have been found to be effective against clonic
seizures induced by subcutaneous pentylenetetrazol that can worsen spike-wave
seizures in patients, it is important to further differentiate a compound found to be
...
James W. Wheless, James Willmore, Roger A. Brumback,
2009
7
Sudden Death in Epilepsy: Forensic and Clinical Issues
This model can identify drugs with varied mechanisms of action and broad
clinical utility for treatment of epilepsy. The pentylenetetrazol intravenous or
subcutaneous seizure test provides a threshold dose for induction of seizures in
individual ...
Claire M. Lathers, Paul L. Schraeder, Michael W. Bungo,
2010
René H. Levy. TABLE 40.1. EFFECTS OF LEVETIRACETAM VERSUS CLASSIC
ANTIEPILEPTIC DRUGS ON SUPRAMAXIMAL ELECTROSHOCK, MAXIMAL
SUBCUTANEOUS PENTYLENETETRAZOL, CORNEAL ...
9
Horizons in Neuropsychopharmacology
Pentylenetetrazol and picrotoxin In an earlier investigation we failed to find
distinctive metabolic changes in brain constituents after treatment of the animal
with pentylenetetrazol or picrotoxin (Stone et al., 1960). We have expanded the
original ...
Williamina A. Himwich,
1965
10
Comparative Diagnostic Pharmacology: Clinical and Research ...
Seizures: Central Nervous System Activity Pentylenetetrazol/Pharmaco-
Electroencephalography Mechanisms of Action: Pentylenetetrazol diminishes the
influence of GABA on chloride ion conductance at concentrations that do not alter
...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «PENTYLENETETRAZOL»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
pentylenetetrazol w wiadomościach.
Anavex Releases Promising Full Preclinical Epilepsy Data at …
In pentylenetetrazol (PTZ)-induced convulsions, the same dose provided 85% protection. In a semicarbazide (SCZ) model, the same dose was ... «GlobeNewswire, Maj 15»
The Relationship Between Autism And Epilepsy
The researchers analyzed seizures through drugs like pentylenetetrazol, used to induce crisis, and valproic acid, an anti-convulsant that is ... «Science 2.0, Kwi 15»
'Don't forget the persecuted despite Norway's independence' – authors
Staff then administered Cardiazol (also known as Pentylenetetrazol), a drug used as a circulatory and respiratory stimulant – high doses can ... «The Foreigner, Lut 14»
Control Underlying Factors Behind Migraines
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. Brain Res. 2010 Jun 2 ... «ProHealth, Gru 13»
'Z: A Novel of Zelda Fitzgerald,' by Therese Anne Fowler
The doctors tried to thin that tar with insulin therapy, or scare it off with electroshock treatments, or blast it from me with pentylenetetrazol, ... «New York Times, Kwi 13»
NCBI ROFL: Wish you could get drunk without blacking out? Next …
Immediately following habituation, rats received saline, 25 mg/kg pentylenetetrazol (a seizure-producing agent known to cause retrograde ... «Discover Magazine, Kwi 12»
Migraine, Epilepsy Drug Topamax May Cause Newborn Cleft Palate
Topiramate inhibits maximal electroshock and pentylenetetrazol-induced seizures as well as partial and secondarily generalized tonic-clonic ... «Medical News Today, Mar 11»
The Hidden Tragedy of the CIA's Experiments on Children
Metrazol was a trade name for pentylenetetrazol, a drug used as a circulatory and respiratory stimulant. High doses cause convulsions, as ... «truthout, Sie 10»
Studies suggest potent therapeutic effects of rufinamide in bipolar …
Rufinamide has activity in the maximal electroshock model and the pentylenetetrazol test, although the ED 50 (median effective dose) is an ... «News-Medical.net, Maj 10»