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1
Thiamine: Catalytic Mechanisms in Normal and Disease States
C. Pyrithiamine-Complexed Structure The TPK inhibitor pyrithiamine was
frequently used to induce thiamine deficiency in rodents due to its ability to
deplete thiamine and produce the neurological syndrome of thiamine deficiency (
30,31).
Frank Jordan, Mulchand S. Patel, 2003
2
Emerging Trends in Antibacterial Discovery: Answering the ...
Pyrithiamine probably exploits this same mechanism to repress TPP biosynthesis
and inhibit fungal growth (Sudarsan et al., 2005). These studies on the action of
pyrithiamine on TPP riboswitches highlight several key principles that may ...
Alita A. Miller, Paul F. Miller, 2011
In other words, the more exacting the organism, the mor sensitive it is to the effect
of pyrithiamine—a phenomenon also observed with other growth inhibitors.
Pyrithiamine and certain derivatives of 6-aminopyrimidine inhibited the utilisation
by ...
Pyrithiamine, an analogue of thiamine, is an extremely effective inhibitor of C.
eugametos : growth of the wild type is completely inhibited by as little as 100 ng
per ml (McBride J.C. & Gowans 1967)! Pyrithiamine inhibition is reversible:
inhibition ...
5
Handbook of Vitamins, Fourth Edition
The second thiamine antagonist shown in Figure 8.3, pyrithiamine, is an example
of a different group of antagonists, all of which have ring modifications in either
the pyrimidine or the thiazole rings, instead of, or in addition to, any changes in ...
Robert B. Rucker, Janos Zempleni, John W. Suttie, 2007
6
Metabolic Inhibitors V1: A Comprehensive Treatise
pyrithiamine, brings about deficiency of cocarboxylase. Pyrithiamine does this by
inhibition of the cocarboxylase-synthesizing enzyme (2, 179), while oxythiamine
is itself pyrophosphorylated by this enzyme, and the resulting product interferes ...
7
Thiamine Deficiency and Associated Clinical Disorders
Results on experiments to analyze the effects of pyrithiamine on vagus nerve
preparations were equivocal. To determine if thiamine might be involved in nerve
conduction, a further look at the mode of action of pyrithiamine was undertaken.
David W. McCandless, 2009
8
Alcohol, Nutrition And the Nervous System
Different analogues may affect these systems to differing degrees according to
the chemical nature of the analogue. Three of the most commonly used
analogues are those of oxy- thiamine, pyrithiamine, and amprolium (Fig. 4).
CHjCHjOH NH ...
9
Time and Behaviour: Psychological and Neurobehavioural Analyses
... proportionally increases the value stored in reference memory and produces a
rightward shift in peak time. A rather indirect route to producing the reference
memory pattern has been to treat subjects with pyrithiamine, a thiamine
antagonist ...
C.M. Bradshaw, E. Szabadi, 1997
10
Antibiotics: Targets, Mechanisms and Resistance
Of particular importance among these analogs is pyrithiamine. This molecule
targets TPP riboswitches and inhibits growth of several bacterial [26, 28, 75] and
fungal [76] species. Similar to thiamine, pyrithiamine is readily phosphorylated ...
Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, 2013
