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1
Molecular Biology and Biotechnology: A Comprehensive Desk ...
Somatic Mutation Theory Hypothesis that aging is caused by the accumulation of
deleterious mutations in the somatic cells of an organism. Somatic cells are all
cells other than the reproductive cells; thus somatic mutations are not heritable.
2
Somatic Hypermutation in V-Regions
at the problem as a bacterial geneticist, giving the somatic mutation idea
molecular rigor and precision. In the process, he expanded and fleshed out
Burnet's half-formed concepts into a set of nine testable propositions. The most
important, for ...
3
Evolutionary Biology of Aging
These explanations are not incompatible with each other, but the first at least
calls into question the relevance of in vitro somatic mutation rate estimates.
Perhaps the best data bearing on the frequency of somatic cell DNA damage
come from ...
Irvine Michael R. Rose Professor of Ecology and Evolutionary Biology University of California, 1990
4
Developmental Biology and Cancer
Tyzzer proposed that the rate of this somatic mutation would be constant
throughout life. This would explain how a tumor could arise in otherwise normal
tissue. However, it did not explain the observed phenomenon of increasing
susceptibility ...
Gisele M. Hodges, Charles Rowlatt, 1993
5
Biology of Aging : Observations and Principles: Observations ...
a synthesis probably due to a somatic mutation in a few cells of that organism.
Isoleucine assays were done on the hemoglobins of two groups of individuals:
those accidentally exposed to radiation (from an atomic bomb test) as youths and
...
Robert Arking Professor of Biological Science Wayne State University, 2006
6
Molecular Genetics of Immunoglobulin
T cells and somatic mutation A large body of data has been amassed indicating
that the structure of antibodies elicited by a T cell dependent form of an antigenic
determinant varies substantially in comparison to a T cell independent form of ...
F. Calabi, M.S. Neuberger, 1987
7
Human B Cell Populations
Within GC, the Isotype Switching Machinery Is Triggered after the Onset of
Somatic Mutation [21] Previous studies have demonstrated that somatic mutation
and isotype switch are two independent processes [36]. An isotype switch can
occur ...
Manlio Ferrarini, Federico Caligaris-Cappio, 1997
8
Crafting Science: A Sociohistory of the Quest for the ...
Efforts to explain carcinogenesis through a control mechanism followed,
especially in the 1950s, the somatic mutation theory mentioned earlier in this
chapter. In 1912 Theodor Boveri proposed that abnormalities of chromosomes
might be a ...
9
Hematopoiesis : A Developmental Approach: A Developmental ...
This also suggests that apoptosis in B cell maturation is triggered before somatic
mutation, a hypothesis that has been supported by in vivo observations.
Centroblasts are characterized by their GC phenotype and their location in the
GC dark ...
Harvard Medical School Leonard I. Zon Associate Professor, 2001
10
The Variation and Adaptive Expression of Antibodies
The Somatic Mutation Theory Then Possibility No. 3 is knocked on the head.
There remain Possibilities No. 1 and 2. Following the methods inculcated at the
University of which I have the honour to be a member, we will now examine
severally ...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «SOMATIC MUTATION»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
somatic mutation w wiadomościach.
Fluxion Biosciences and Swift Biosciences Announce Jointly …
... clinical research designed to detect somatic mutations from a routine blood draw. ... Swift's Accel-Amplicon 56G Oncology Panel provides sensitive mutation ... «MarketWatch, Maj 15»
Cancer-Driving Mutations Common in Normal Skin Cells
Addressing how somatic mutations may accumulate in normal tissue, the team, led by Campbell and Philip Jones of the University of Cambridge's Medical ... «The Scientist, Maj 15»
Epigenetic Drivers of Somatic Mutations in Cancer
With next-generation sequencing, it is possible to distinguish between de novo mutations that drive cancer and those that are "along for the ride. «Genetic Engineering & Biotechnology News, Kwi 15»
Heritable ETV6 mutation is genetic cause of acute lymphoblastic …
Porter explains that somatic mutation of the gene ETV6 requires the presence of ... This study is one of two new reports to show that "germline" mutation of ETV6, ... «Science Codex, Mar 15»
Mutated ATRX gene linked to brain tumors potential biomarker for …
A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas ... «Medical Xpress, Sty 15»
Tracking subtle brain mutations, systematically
The technique picks up somatic mutations that affect just a fraction of the brain's cells, in a "mosaic" pattern. It also allows "lineage tracing," showing when during ... «PR Newswire, Sty 15»
Study Uses Novel Algorithm to ID Rare Somatic Mutations with …
NEW YORK (GenomeWeb) – Researchers from Brown University and other institutions have published a study in which they used an algorithm called HotNet2 ... «GenomeWeb, Sty 15»
Clonal Hematopoiesis with Somatic Mutations Up with Age
(HealthDay News) — Clonal hematopoiesis with somatic mutations is increasingly common with aging, according to two studies published online November 26 ... «Monthly Prescribing Reference, Gru 14»
Precancerous state found in blood
These two new studies instead looked at somatic mutations — mutations that ... some but not all — of the somatic mutations that are present in blood cancers. «Harvard Gazette, Lis 14»
Somatic Mutations in the ATRX Gene Reported for the First Time in …
Somatic mutations in the ATRX gene are observed in about 13% of pheochromocytomas/paragangliomas, the first such report of somatic ATRX mutations in ... «OncLive, Paz 14»
