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1
Cell Signaling: principles and mechanisms
This mechanism results in a sigmoidal, switchlike activation of PKA in response
to increasing cAMP concentration. This effect is amplified by the fact that inactive
PKA is a heterotetramer (two catalytic and two regulatory subunits, with a total of
...
Wendell Lim, Bruce Mayer, Tony Pawson, 2014
2
Issues in Biophysics and Geophysics Research and ...
Fresh data on life science are presented in the report 'A combination of multisite
phosphorylation and substrate sequestration produces switchlike responses.' “
The phosphorylation of a protein on multiple sites has been proposed to promote
...
3
CWNA: Certified Wireless Network Administrator Official ...
The original CWNP definition of an access point (AP) was a half-duplex device
with switchlike intelligence. That definition can still be used to characterize
autonomous access points and cooperative access points. In Chapter 10, we will
...
David D. Coleman, David A. Westcott, 2012
4
Systems Biology in Drug Discovery and Development
By integrating a series of continuous and switchlike nonlinear dose–response
behaviors in individual cells to describe the response at the tissue and organism
level, systems biology can help provide a mechanistic basis for incidence-dose ...
Daniel L. Young, Seth Michelson, 2011
5
The Evolution of Social Wasps
In her ovarian ground plan hypothesis, a switchlike mechanism is proposed to
evolve de novo with or after caste divergence, whereas the diapause ground
plan hypothesis of caste divergence is based on context-dependent co-option of
a ...
St. Louis James H. Hunt Professor of Biology University of Missouri, 2007
6
Functional Metabolism: Regulation and Adaptation
This is believed to occur because scaffolds can create kinase complexes that are
able to channel reacTEXT BOX 5.3 CONFLICTING VIEWS ON SCAFFOLD
FUNCTION Does Scaffolding Affect a Pathway's “Switchlike” Behavior? The
current ...
7
Targeting Protein Kinases for Cancer Therapy
Both the CDK1/CDC25/WEE1/MYT1 system and the negative feedback loop (
CDK1APC/C CDC20 ) are required for sustained, switchlike cell cycle oscillations
in Xenopus egg extracts (148, 149). In somatic cells, another form of the APC/C, ...
David J. Matthews, Mary E. Gerritsen, 2011
8
Archaeology at the Millennium: A Sourcebook
ones previously studied, however, shows that Heinrich events and switchlike
Dansgaard–Oeschger cycles spaced at intervals of roughly 1500 years
characterize the Holocene and Pleistocene interglacials as well as Pleistocene
glacials, and ...
Gary M. Feinman, T. Douglas Price, 2007
9
Biosphere Origin and Evolution
Lai and coauthors have analyzed the robustness of the switchlike behavior of the
vertebrate Hh-cascade (Lai et al., 2004); their simulation has demonstrated that
bistable behavior of the Hh-system is consistent with the experimental data; ...
Nikolay Dobretsov, Nikolay Kolchanov, Alexey Rozanov, 2007
10
Biophysics: Searching for Principles
or switchlike as F becomes larger. Cooperativity means, in this context, that the
free-energy change upon binding of a calcium ion to one site is increased by
occupancy of the other site. Relate the parameter F to this free-energy difference
or ...
