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1
Medicinal Organometallic Chemistry
Atoxyl amblyopia is the result of optic nerve atrophy, with primary involvement of
the retina, though in certain cases lesions, shown experimentally and apparently
clinically, are very suggestive [22,23]. 3.2 Tryparsamide Tryparsamide ...
Gérard Jaouen, Nils Metzler-Nolte, 2010
2
Approaches to Design and Synthesis of Antiparasitic Drugs
The drugs, which have been used successfully against African trypanosomiasis (
African sleeping sickness) caused by Trypanosoma brucei gambiense and T.
brucei rhodesiense, are tryparsamide (7), melarsoprol (Mel B, 8a), melarsonyl ...
N. Anand, S. Sharma†, 1997
3
"The Cruel Madness of Love": Sex, Syphilis and Psychiatry in ...
They concluded that it remained unproven whether tryparsamide was really more
potent than other arsenicals, but deemed the drug worthy of further trial, it being
easy to administer and not toxic in the doses used.144 In Scotland, the trials of ...
4
Chemotherapy of Tropical Parasitic Infections
Structure and Physical Properties n HO-As-OH NHCHjOONHj Tryparsamide MW
310 (dihydrate). It is soluble 1:1.5 in water. The drug should be stored in a cool
place in airtight containers and be protected from light. Pharmacology and Mode
...
5
PROGRESS IN MEDICINAL CHEMISTRY
For example, substitution in the benzene ring and acylation of the amino-group
afforded Orsanine or Fourneau 270 (111), preferred by French workers to
tryparsamide. Neocryl (IV) was the result of more complex modification of the ...
Gwynn Pennant Ellis, Geoffrey Buckle West, 1963
6
A History of the Rockefeller Institute, 1901-1953: Origins ...
Readers familiar with organic chemistry will appreciate the reasoning which led
Jacobs to prepare Tryparsamide. Ehrlich had made certain arsenical compounds
which were strongly trypanocidal, among them arsenophenylglycine.
George Washington Corner, 1965
7
Women Pioneers of Medical Research: Biographies of 25 ...
studied the effect of each dose of tryparsamide on more than seventy patients
and observed the complete eradication of the parasite in the blood and nervous
system within a few weeks of the treatment with no side effects. Dr. Pearce's ...
In the 1920s, the introduction of tryparsamide, a drug developed at the
Rockefeller Institute, resulted in a dramatic improvement: patients with
involvement of the brain could now be cured. Just for 1927–8, 900 kg of atoxyl (
about one million ...
The new arsenical, named Tryparsamide by Simon Flexner, was found to be
extremely effective in trypanosome infected animals by Drs. Wade H. Brown and
Louise Pearce, who now formed part of the chemotherapeutic team. Several
patents ...
Office of the Home Secretary, National Academy of Sciences, 1980
10
A Handbook Of Psychiatry
With fever and tryparsamide therapy approxi- mately two thirds of the paretics are
greatly or moderately improved. The other one third show no improvement, but
the downhill course of the disease may be slowed or even halted. The prognosis
...
Perry Maurice Lichtenstein, Lichtenstein, P M & Small, S M, 2013
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «TRYPARSAMIDE»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
tryparsamide w wiadomościach.
C'est arrivé le 8 juin 1931Le Dr Jamot et la maladie du sommeil
A Bafia au Cameroun, en 1928, l'administration par un jeune médecin de tryparsamide à des doses trop élevées, avait conduit à la cécité de 700 sommeilleux. «Le Généraliste, Cze 14»
