KSIĄŻKI POWIĄZANE ZE SŁOWEM «VINCA ALKALOID»
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1
Current Pharmaceutical Design
Naturally Occurring Vinca Alkaloids and Related Compounds Besides
vinblastine and vincristine, several natural products that bind to the vinca alkaloid
binding site on tubulin have been discovered. Their antimitotic antitumor
properties have ...
2
Cancer Chemotherapy and Biotherapy: Principles and Practice
Self- propagation occurs as vinca alkaloid binding progressively weakens the
lateral interactions between protofilaments, induces conformation changes in
tubulin, and exposes new sites. The exposure of new sites further increases the ...
Bruce A. Chabner, Dan L. Longo, 2011
3
The Role of Microtubules in Cell Biology, Neurobiology, and ...
(77) interpreted their binding data as indicating maytansinoids and rhizoxin
bound at a common site on tubulin distinct from the vinca alkaloid-binding site.
IC50s of these compounds against a variety of cell lines range from 0.5 to 1 nM
for ...
4
Energetics of Biological Macromolecules
[4] Energetics of Vinca Alkaloid Interactions with Tubulin This chapter presents a
detailed discussion of the energetics of interactions between Vinca rosea L. (
vinca) alkaloids, antimitotic chemotherapeutic agents, and tubulin, the major
protein ...
5
Holland Frei Cancer Medicine Eight
Expression of B-II tubulin, which appears to depend on TP53 suppressor function
, may also relate to vinca alkaloid resistance.93 Increased expression of MAPs,
particularly MAP4, has also been associated with vinca alkaloid resistance.94 ...
Waun Ki Hong, American Association for Cancer Research, William Hait, 2010
6
Leukemia: New Insights for the Healthcare Professional: 2013 ...
An unexpected finding was the enhanced activity of the 10'-fluorinated vinca
alkaloids compared to their unsubstituted parental vinca alkaloid compounds (10'
-hydrido vinca alkaloid compounds), and particularly the enhanced activity
against ...
7
Drugs Affecting Growth of Tumours
... thrombosis 172 vinblastine, administration 107 vinblastine, metabolism 105
vinca alkaloids 102–108 vinca alkaloid, clinical activity and toxicity 106 vinca
alkaloid, clinical pharmacology 104 vinca alkaloid, drug interaction 105 vinca
alkaloid, ...
Herbert M. Pinedo, Carolien H. Smorenburg, 2007
8
Cancer Management in Man: Chemotherapy, Biological Therapy, ...
The two most investigated members of this family in regards to vinca alkaloid
resistance are the permeability glycoprotein (P-gp)/MDR1 endcoded gene
product (ABC subfamily B1;ABCB1) and the multidrug resistance protein MRP (
ABC ...
Divalent cation and ionic strength effects on vinca alkaloid-induced tubulin self-
association. Biophys. J. 72, 416–427. Lobert, S., and Correia, J. J. (2000).
Energetics of vinca alkaloid interactions with tubulin. Meth. Enzymol. 323, 77–
103.
Leslie Wilson, John J. Correia, 2010
10
A Dictionary of Genetics
In glial cells it is copolymerized with an acidic protein of 50,000 daltons, while in
muscle cells it is combined with viroid 501 desmin It also occurs in the Z disk of
cardiac and skeletal muscle cells. vinblastine a Vinca alkaloid which is used as
an ...
Robert C. King, Pamela Mulligan, William Stansfield, 2013
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «VINCA ALKALOID»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
vinca alkaloid w wiadomościach.
Cell-Division Inhibitor Performs Only in the Spotlight
... powerful chemotherapeutic Taxol, or the Vinca alkaloids. These drugs interfere with microtubule dynamics, and hence cell division, preventing the proliferation ... «Genetic Engineering & Biotechnology News, Lip 15»
Novogen Develops New Class Of Drugs
Its lead anti-tropomyosin dug, Anisina, shows strong synergy with standard-ofcare anti-mitotic vinca alkaloid drugs. The company is well-funded, having raised ... «Investing.com, Lip 15»
Global Hodgkins Lymphoma Therapeutics Market 2014-2018
... segments: Alkylating Antineoplastic Agents, Antibiotic Antineoplastic Agents, Antineoplastics Vinca Alkaloid Agents, Podophyllotoxin Derivative Antineoplastic ... «Medgadget.com, Lip 15»
Anisina on Track to Enter Clinic in 2016
This is the same target of the most widely used chemotherapy drugs in cancer, the taxanes and vinca alkaloids. These latter drugs are standard of care for some ... «PR Newswire, Cze 15»
Novogen Initiation Of Coverage
Its lead anti-tropomyosin drug, Anisina, shows strong synergy with standard-ofcare anti-mitotic vinca alkaloid drugs. The company is well funded, having raised ... «Investing.com, Cze 15»
ATM Technology Extended with New Patent Lodgement
... chemotherapy: the taxanes and the vinca alkaloids. This combined attack on two major components of the cell cytoskeleton, microfilaments and microtubules, ... «PR Newswire, Maj 15»
Endocyte Announces Presentations at American Association for …
Vintafolide is an investigational proprietary, injectable, SMDC consisting of folate (vitamin B9) linked to a potent vinca alkaloid chemotherapy agent, ... «GlobeNewswire, Kwi 15»
Australian Studies Confirm Anisina as Potential Important New …
It is being brought into the clinic for the treatment of cancers as a companion drug for the anti-mitotic family of drugs…the taxanes and vinca alkaloids. «PR Newswire, Kwi 15»
Vaccine Slows Advanced Ovarian Cancer
... 2.7 months with PLD alone to 5.0 months with PLD plus vintafolide, a conjugate consisting of folic acid and the vinca alkaloid desacetylvinblastine hydrazide. «MedPage Today, Mar 15»
Potential of Anisina to Become Major New Chemotherapy …
These drugs are known as 'anti-mitotics' and include the taxanes (paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine). Collectively, these ... «PR Newswire, Mar 15»
