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1
Integration of Metabolism, Energetics, and Signal ... - 57페이지
Recent evidence indicates that AMPK plays a critical and central role in both malonyl CoA-dependent and malonyl CoA-independent regulation of CPT-I and, thus, mitochondrial fatty acid oxidation (Fig. 4.2). Malonyl CoA-dependent regulation ...
2
Metabolic Acidosis - 123페이지
Rather, malonyl-CoA, the first committed intermediate in long-chain fatty acid synthesis, proved to be the primary regulatory molecule, exhibiting powerful inhibitory effects on the carnitine acyltransferase system (McGarry et al 1977).
CIBA Foundation Symposium,
2009
3
Biochemistry for Sport and Exercise Metabolism - 171페이지
Does malonyl-CoA regulate LCFA uptake? The mechanisms underpinning the reduction in LCFA entry to the mitochondria likely involve CPTI activity. In this regard, early attention focused on malonyl-CoA, which is a potent inhibitor of CPTI ...
Donald MacLaren, James Morton,
2011
4
Drug Discovery and Evaluation: Pharmacological Assays
The CT reaction is assayed in the reverse direction in which malonyl-CoA reacts with biocytin (an analog of the biotin carboxyl carrier protein) to form acetyl-CoA and carboxybi- otin. The production of acetyl-CoA is coupled to citrate synthase, ...
5
Teaching Innovations in Lipid Science - 232페이지
Randall J. Weselake. Acetyl-CoA Acetyl-CoA Acetyl-CoA 1 CO2, ATP 1 CO2, ATP Malonyl-CoA Malonyl-CoA Malonyl-CoA 2 ACP 2 ACP Malonyl-ACP Malonyl-ACP Malonyl-ACP 3-Ketobutyryl-ACP CO2 3-Ketobutyryl-ACP 3-Ketobutyryl-ACP ...
Randall J. Weselake,
2007
6
An Introduction to Agricultural Biochemistry - 253페이지
Here pyruvate dehydrogenase converts it to acetyl-CoA which enters the TCA cycle where it condenses with ... 19.4 PRODUCTION OF MALONYL-COA In addition to acetyl-CoA, malonyl-CoA is also an essential substrate for fatty acid ...
J.M. Chesworth, T. Stuchbury, J.R. Scaife,
1998
7
Study Guide with Student Solutions Manual and Problems ...
... to serine (CoA in degradation) Fatty acid synthase: Multienzyme complex Carbons derived from acetyl units Acetyl CoA to malonyl CoA by carboxylation Acetyl unit added to fatty acid with decarboxylation of malonyl CoA Carbonyl ...
Garrett, Reginald H.,
2012
8
Papers in biochemistry - 237페이지
CoA were from P-L Biochemicals, Inc., Milwaukee, Wis. Standard solutions of malonyl-CoA were prepared from a stock solution whose concentration was determined spectrophotometrically according to the method of Guynn et al. (4).
9
Introduction to Nutrition and Metabolism, Fourth Edition - 305페이지
CoA, and hence increased formation of citrate, which is exported to the cytosol for fatty acid synthesis (see Figure 5.27 and section 5.6.1). • Insulin also stimulates the activity of acetyl CoA carboxylase, leading to increased formation of malonyl ...
10
Mitochondrial Dysfunction: Methods in Toxicology - 2권 - 301페이지
Although the heart is incapable of fatty acid synthesis de novo, the isolation of a cardiac-specific isoform of acetyl-CoA carboxylase (2,3) suggests that malonyl-CoA can be synthesized in the myocardium. Thus, malonyl-CoA may be an ...
Lawrence H. Lash, Dean P. Jones,
2013