KSIĄŻKI POWIĄZANE ZE SŁOWEM «NIRVANOL»
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(b) In the light of a previous observation (Kiipfer et al., 1984a) suggesting a
parallel in the metabolism of mephenytoin and nirvanol a panel study was
undertaken in 10 EMs and 10 PMs of mephenytoin to test the genetic hypothesis
that the ...
2
Genetic Factors in Drug Therapy: Clinical and Molecular ...
It has been known for a long time that the drug is partially metabolized in man by
demethylation to 5-phenyl-5-ethyl- hydantoin (nirvanol). Alternatively,
mephenytoin is metabolized by aromatic hydroxylation to 3-methyl-5- (4-
hydroxyphenyl) ...
David A. Price Evans, 1993
3
Epilepsy: A Comprehensive Textbook
of mephenytoin have been reviewed elsewhere.89 Mephenytoin, Nirvanol (active
metabolite), and other mephenytoin metabolites can be quantified by HPLC,89
and other methods exist to quantify the enantiomers of these molecules.89 ...
Jerome Engel, Timothy A. Pedley, Jean Aicardi, 2008
4
Drugs for the Control of Epilepsy
The second major biotransformation that mephenytoin undergoes is N-
demethylation at the three position to form 5-ethyl-5-phenylhydantoin (Nirvanol).
Nirvanol is the name of an old drug introduced as a hypnotic but removed from
therapy ...
Carl L. Faingold, Gerhard H. Fromm, 1991
5
The journal of pharmacology and experimental therapeutics
the total plasma clearance was 6.8 ml min" kg“ (table 1). Interestingly, the
mongrel dog (no. 4), exhibiting slow metabolism of ethanol, had the highest
mephenytoin clearance and exhibited the largest amounts of nirvanol in plasma
and mine.
6
Reproductively Active Chemicals: A Reference Guide
... CDR750, PAKOOO NIRAN E-4 see PAKOOO NIRATIC HYDROCHLORIDE
see LFA020 NIRATIC-PURON HYDROCHLORIDE see LFA020 NIRIDAZOLE
see NMLOOO (-(-NIRVANOL see EOL050 I-NIRVANOL see EOL050 (R)-
NIRVANOL ...
7
CURRENT TOPICS DEVELOPMENTAL BIOLOGY
(1982) have shown that embryonic toxicity was produced by L-nirvanol, a
metabolite of the hydantoin mephenytoin, but not by its D isomer, D-nirvanol.
Only L-nirvanol, the isomer producing less arene oxide, demonstrated embryonic
toxicity, ...
8
Synthetic Organic Chemistry: (For Honours & Post-Graduate ...
O. P. Agarwal. However, the barbiturates used for sedation and to produce sleep
are addicting with prolonged use of large doses. Large overdoses will result in
respiratory failure and death. 5. Hydantoin Derivatives. Nirvanol (phenyl ethyl ...
9
Ars Medici: The Journal for the Medical Practitioner
so-called "nirvanol sickness", had a curative effect on chorea. And since then it
has been used to cure chorea minor. Compared with the usual treatment with
Fowler's solution, luminal, arsphenamine, spirocid, and milk injections, nirvanol
has ...
phenytoin and Nirvanol were 10 ng/ml and 50 ng/ml, respectively, and the results
were found to be reproducible within 8% on repeated assay. Absorption,
Distribution, and Excretion Absorption and Distribution The rate and extent of ...
Dixon M. Woodbury, J. Kiffin Penry, C. E. Pippenger, 1982
