ЧТО ОЗНАЧАЕТ СЛОВО MORPHOGEN
морфоген
Морфоген представляет собой вещество, определяющее закономерность развития ткани в процессе морфогенеза, и положения различных специализированных типов клеток в ткани. Точнее, морфоген является сигнальной молекулой, которая действует непосредственно на клетки для получения специфических клеточных ответов в зависимости от ее локальной концентрации. Поскольку морфогены диффундируют через ткани эмбриона во время раннего развития, настроены градиенты концентрации. Эти градиенты управляют процессом дифференциации неспециализированных клеток в разные типы клеток, в конечном итоге формируя все ткани и органы тела.
Значение слова morphogen в словаре английский языка
Определение морфогена в словаре - это химическое вещество, обнаруженное в ткани, которое влияет на развитие клеток во время морфогенеза путем формирования градиента концентрации.
КНИГИ НА АНГЛИЙСКИЙ ЯЗЫКЕ, ИМЕЮЩЕЕ ОТНОШЕНИЕ К СЛОВУ «MORPHOGEN»
Поиск случаев использования слова
morphogen в следующих библиографических источниках. Книги, относящиеся к слову
morphogen, и краткие выдержки из этих книг для получения представления о контексте использования этого слова в литературе на английский языке.
1
Generation and interpretation of
morphogen gradients: a ...
Written and edited by experts in the field, this volume explores how morphogen gradients are generated and interpreted during development.
James Briscoe, Peter Anthony Lawrence, Jean-Paul Vincent,
2010
2
Life: The Science of Biology
Morphogen gradients provide positional information During development, the key
cellular question, "What am I (or what will I be)?" is often answered in part by "
Where am I?" Think of the cells in the developing nematode, which develop into ...
H. Craig Heller, David M. Hillis,
2011
3
Shh and Gli Signalling in Development
To qualify as a morphogen, a signal must fulfil two criteria: to form a concentration
gradient, and to elicit distinct responses at different concentrations. Cells
encounter different concentrations of a morphogen according to their distance
from the ...
Sarah Howie, Carolyn Elaine Fisher,
2008
4
Signal Transduction Research Trends
Nickolas O. Grachevsky. Shh was first reported as a morphogen in the limb
development (Figure 2A). Classical grafting experiments using chick embryos
had revealed existence of zone of polarizing activity (ZPA) in the posterior limb
bud [41, ...
Nickolas O. Grachevsky,
2007
5
Biological Physics of the Developing Embryo
Here the effect of the morphogen spreads as if by diffusion, but what is actually
propagating across the domain is an activity passed from cell to cell by signaling
rather than by any substance (Reilly and Melton, 1996). In addition, morphogens
...
Gabor Forgacs, Stuart A. Newman,
2005
6
Patterning and Cell Type Specification in the Developing CNS ...
The concept of a morphogen can be traced to the turn of the twentieth century,
when Morgan postulated the presence of 'formative substances' as the basis for
differ- ent regeneration rates in worms (Morgan, 1901). Very soon thereafter,
Boveri ...
Normal morphogen gradient M with L (lower) and H (higher) thresholds for
Hoxa13 activation. Additional morphogen sources at the tip increase M to M1 or
M2. additional morphogen source is inserted at the distal tip, the gradient
increases to ...
Spyros Papageorgiou,
2007
By definition, a morphogen acts locally to organize the spatial pattern of cell
differention by virtue of spatial concentration differences. A high concentration of
a morphogen at location 1 specifies cell type or structure A, a lower concentration
at ...
9
Wnt Signaling in Development
As a minimal definition, an extracellular morphogen is a molecule that can
spread out from a localized source and directly instruct cell identities in a
concentration-dependent manner. For secreted signaling proteins to fulfill these
criteria ...
10
Systems Biomedicine: Concepts and Perspectives
FIGURE 14.3 The Role of Receptor–Ligand Trafficking in Morphogen Transport.
Receptor–ligand trafficking plays a crucial role in establishing morphogen
gradients, irrespective of whether morphogen transport occurs by (A) diffusion or
(B) ...
Edison T. Liu, Douglas A. Lauffenburger,
2009
НОВОСТИ, В КОТОРЫХ ВСТРЕЧАЕТСЯ ТЕРМИН «MORPHOGEN»
Здесь показано, как национальная и международная пресса использует термин
morphogen в контексте приведенных ниже новостных статей.
Analysis of the TGFβ-induced program in primary airway epithelial …
TGFβ-induced EMT is modulated by a variety of signals including cytokine stimulation, morphogen signaling, and ECM interactions. «BMC Blogs Network, Июл 15»
Self-organizing human cardiac microchambers mediated by …
Future studies on lineage tracking, and morphogen gradient and fate mapping, will further elucidate linkages between early cardiac ... «Nature.com, Июл 15»
Synergistic activity of polarised osteoblasts inside condensations …
The environmental variables can include presence of biological structures or gradients of a chemokine or morphogen, amongst others. «Nature.com, Июл 15»
[Review] BMP gradients: A paradigm for morphogen-mediated …
Bone morphogenetic proteins (BMPs) act in dose-dependent fashion to regulate cell fate choices in a myriad of developmental contexts. «Military Technologies, Июн 15»
Mesenchymal Adenomatous Polyposis Coli plays critical and …
Moreover, lung epithelial branching morphogenesis was drastically inhibited due to disrupted Bmp4-Fgf10 morphogen production and ... «7thSpace Interactive, Июн 15»
A microRNA code for prostate cancer metastasis
Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient. Development 2012; 139: 2721–2729. «Nature.com, Июн 15»
Why Are Human Eggs So Huge?
Morphogen behaviour is concentration-dependent. That means they tell cells slightly different things depending on how much of the molecule a ... «Gizmodo Australia, Май 15»
How fancy cats evolved: The science of our most adorable pets
Sonic hedgehog is a master developmental regulatory gene that produces a protein molecule of a sort called a “morphogen,” which forms a ... «Salon, Май 15»
h+ Media | ALK5 A Single Drug Simultaneously Rejuvenates …
... either anti- or pro-inflammatory depending on the levels of this morphogen and the gene expression landscape of the responding tissue [29, ... «h+ Magazine, Май 15»
Body Proportions Go Back to the Egg … and Its Ration of Maternal …
A new scaling model links morphogen gradients in Drosophila fruit fly embryos with maternal tissue expansion. [Matt Kofron/Cincinnati ... «Genetic Engineering & Biotechnology News, Мар 15»