与 «HISTONE»相关的英语书籍
在以下的参考文献中发现
histone的用法。与
histone相关的书籍以及同一来源的简短摘要提供其在 英语文献中的使用情境。
1
Histone Deacetylase Inhibitors as Cancer Therapeutics
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics.
2
Histone Deacetylases: Transcriptional Regulation and Other ...
They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in ...
3
Histone Deacetylases: the Biology and Clinical Implication: ...
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, ...
Tso-Pang Yao, Edward Seto, 2011
4
Histone Cross-talk During Transcription Elongation in ...
Taken together, these results present a better defined and more integrative model of transcription elongation, which is emerging as a highly regulated stage in transcriptional responses to developmental and cellular signaling.
Anti-histone antibodies are the most common autoantibody specificity in DIL, and
most patients with symptomatic drug-induced disease demonstrate elevated
levels of IgG anti-histone antibodies. Antibodies to histones are also frequent in
SLE ...
6
The
Histone Code and Beyond: New Approaches to Cancer Therapy
Since deregulation of epigenetic marks has been reported in many cancers, an understanding of the molecular mechanisms bears the promise that drug targets may be found. The developments in this field are presented in this book.
Shelley L. Berger, O. Nakanishi, Bernhard Haendler, 2007
7
The Cell Cycle: Principles of Control
4-10 Histone Synthesis in S phase histone mRNA processing histone synthesis
histone mRNA synthesis transcriptional activation SLBP protein RNA nucleases
? transcriptional repression histone mRNA stabilization cell-cycle control system
...
8
Histones and Other Basic Nuclear Proteins
studies indicates that in continuously dividing cell populations and after
stimulation of quiescent cells to proliferate, the level of human histone mRNA
accumulation reflects cellular levels of both histone protein synthesis and DNA
replication.
Gary S. Stein, Janet L. Stein, 1989
9
Cancer Modelling and Simulation
2.4.2 Histone Modifying Enzymes Covalent posttranslational modifications of
histones are critical for nucleosome stability, and thus chromatin organisation.
Acetylation/deacetylation is the most studied covalent modification of histones
that ...
The N-terminal tail of histone H4 can be cross-linked to DNA at i 1.5 tums from
the dyad axis, coincident with the sites of strong DNA deformation (Ebralidse et al
., 1988). A second feature of histone-DNA interaction around the dyad axis of the
...
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Premarket Biotech Digest: JNJ Earnings, Celgene Making Deals …
In another deal, Celgene and Epizyme (NASDAQ:EPZM) have agreed to extend their collaboration in HMT (histone methyltransferase) ... «Seeking Alpha, 七月 15»
New roles revealed for immune-regulatory protein may have …
An equally important finding was that NFATc2 altered the chemical modification pattern of histone proteins associated with DNA within ... «Medical Xpress, 七月 15»
Pharmacyclics, Inc. (NASDAQ:PCYC) Brokerage Rating Update
... and a histone deacetylase (HDAC) inhibitor (PCI-24781) in Phase I and II clinical trials in solid tumors and hematological malignancies as of ... «Investor Newswire, 七月 15»
Tetralogic Pharmaceuticals Corp Director Andrew L. Pecora …
SHAPE is a histone deacetylase (HDAC) inhibitor for topical use for the treatment of early-stage cutaneous T-cell lymphoma (CTCL) and is in ... «Dakota Financial News, 七月 15»
MEI Pharma Receives $3.63 Average PT from Analysts (NASDAQ …
Pracinostat is an orally available histone deacetylase (NASDAQ:MEIP) inhibitor that is being developed for advanced hematologic diseases ... «WKRB News, 七月 15»
Search for common targets of lithium and valproic acid identifies …
Valproic acid (VPA) is a histone deacetylase inhibitor, and lithium (Li) may have downstream epigenetic actions. To identify genes commonly ... «Nature.com, 七月 15»
Wayne State Receives $1.9 Million NIH Grant for Enhancing EPC …
... lysine methylation of the chemokine receptor CXCR2 by a histone methyltransferase SMYD1 in modulating EPC migration and angiogenesis ... «Newswise, 七月 15»
Xenetic Biosciences Reports Phase 2 Data on Drug Candidate …
... treatment of anemia in pre-dialysis patients with chronic kidney disease, and OncoHist®, a novel recombinant human histone H1.3 molecule ... «Nasdaq, 七月 15»
Insider Buying: Tetralogic Pharmaceuticals Corp Director Andrew L …
SHAPE is a histone deacetylase (HDAC) inhibitor for topical use for the treatment of early-stage cutaneous T-cell lymphoma (CTCL) and is in Phase II clinical ... «Dakota Financial News, 七月 15»
Epigenetics: Disrupting histone lysine methylation
Histone lysine methylation states are regulated by methyltransferases and demethylases. Histone methyltransferase enzymes often function as ... «Nature.com, 七月 15»
