在"英语"词典里missense}的意思

在英语中MISSENSE的发音

missense  [ˌmɪsˈsɛns]

MISSENSE在英语中的意思是什么？

错误突变

Missense mutation

在遗传学中，错义突变是点突变，其中单个核苷酸变化导致编码不同氨基酸的密码子。 错义突变可使得到的蛋白质不起作用，并且这种突变对诸如大疱性表皮松解症，镰状细胞病和SOD1介导的ALS等疾病负责。 导致代码截断的特殊类型的错义突变是密码子变为终止密码子的无义突变。 镰状细胞病最常见的变体是血红蛋白β链基因的第20个核苷酸，从密码子GAG改为GUG。 因此，第六氨基酸谷氨酸被替代为缬氨酸 - 被称为“E6V”突变 - 并且蛋白质被充分改变以引起镰状细胞病。 不是所有的错义突变导致明显的蛋白质变化。 氨基酸可以被非常相似的化学性质的氨基酸替代，在这种情况下，蛋白质仍然可以正常地起作用; 这被称为中性，“安静”，“沉默”或保守的突变。

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. Missense mutations can render the resulting protein nonfunctional, and such mutations are responsible for diseases such as Epidermolysis bullosa, sickle-cell disease, and SOD1 mediated ALS. A special type of missense mutation that results in truncation of code is the nonsense mutation in which a codon is changed to a stop codon. The most common variant of sickle-cell disease, the 20th nucleotide of the gene for the beta chain of hemoglobin is altered from the codon GAG to GUG. Thus, the 6th amino acid glutamic acid is substituted for valine — notated as an "E6V" mutation — and the protein is sufficiently altered to cause the sickle-cell disease. Not all missense mutations lead to appreciable protein changes. An amino acid may be replaced by an amino acid of very similar chemical properties, in which case, the protein may still function normally; this is termed a neutral, "quiet", "silent" or conservative mutation.

在英语 词典里missense的定义

字典中错义的定义是给错误的意义或意义。

英语动词MISSENSE的变化形式

PRESENT

Present

I missense

you missense

he/she/it missenses

we missense

you missense

they missense

Present continuous

I am missensing

you are missensing

he/she/it is missensing

we are missensing

you are missensing

they are missensing

Present perfect

I have missensed

you have missensed

he/she/it has missensed

we have missensed

you have missensed

they have missensed

Present perfect continuous

I have been missensing

you have been missensing

he/she/it has been missensing

we have been missensing

you have been missensing

they have been missensing

PAST

Past

I missensed

you missensed

he/she/it missensed

we missensed

you missensed

they missensed

Past continuous

I was missensing

you were missensing

he/she/it was missensing

we were missensing

you were missensing

they were missensing

Past perfect

I had missensed

you had missensed

he/she/it had missensed

we had missensed

you had missensed

they had missensed

Past perfect continuous

I had been missensing

you had been missensing

he/she/it had been missensing

we had been missensing

you had been missensing

they had been missensing

FUTURE

Future

I will missense

you will missense

he/she/it will missense

we will missense

you will missense

they will missense

Future continuous

I will be missensing

you will be missensing

he/she/it will be missensing

we will be missensing

you will be missensing

they will be missensing

Future perfect

I will have missensed

you will have missensed

he/she/it will have missensed

we will have missensed

you will have missensed

they will have missensed

Future perfect continuous

I will have been missensing

you will have been missensing

he/she/it will have been missensing

we will have been missensing

you will have been missensing

they will have been missensing

CONDITIONAL

Conditional

I would missense

you would missense

he/she/it would missense

we would missense

you would missense

they would missense

Conditional continuous

I would be missensing

you would be missensing

he/she/it would be missensing

we would be missensing

you would be missensing

they would be missensing

Conditional perfect

I would have missense

you would have missense

he/she/it would have missense

we would have missense

you would have missense

they would have missense

Conditional perfect continuous

I would have been missensing

you would have been missensing

he/she/it would have been missensing

we would have been missensing

you would have been missensing

they would have been missensing

IMPERATIVE

Imperative

you missense
we let´s missense
you missense

NONFINITE VERB FORMS

Infinitive

to missense

Past participle

missensed

Present Participle

missensing

MISSENSE的翻译

通过我们的英语多语言翻译器,找到missense的25种语言翻译

该章节所呈现的将missense由 英语向其他语言的翻译是通过自动统计翻译获得的；在英语中基本的翻译单位是单词«missense»。

• 翻译者英语 - 中文: 错义
• 翻译者英语 - 西班牙语: missense
• 英语: missense
• 翻译者英语 - 印地语: missense
• 翻译者英语 - 阿拉伯语: مغلطة
• 翻译者英语 - 俄语: миссенс
• 翻译者英语 - 葡萄牙语: missense
• 翻译者英语 - 孟加拉语: missense
• 翻译者英语 - 法语: faux-sens
• 翻译者英语 - 马来语: Kesengsaraan
• 翻译者英语 - 德语: Missense
• 翻译者英语 - 日语: ミスセンス
• 翻译者英语 - 韩语: 과오
• 翻译者英语 - 印尼爪哇语: Missense
• 翻译者英语 - 越南语: missense
• 翻译者英语 - 泰米尔语: missense
• 翻译者英语 - 马拉地语: मिसेंस
• 翻译者英语 - 土耳其语: yanlış anlamlı
• 翻译者英语 - 意大利语: missenso
• 翻译者英语 - 波兰语: zmiany sensu
• 翻译者英语 - 乌克兰语: міссенс
• 翻译者英语 - 罗马尼亚语: missense
• 翻译者英语 - 希腊语: παρανοηματική
• 翻译者英语 - 布尔语(南非荷兰语): missense
• 翻译者英语 - 瑞典语: missense
• 翻译者英语 - 挪威语: missense

与 «MISSENSE»相关的英语书籍

在以下的参考文献中发现missense的用法。与missense相关的书籍以及同一来源的简短摘要提供其在 英语文献中的使用情境。

Characterization of Ribosomal Protein L2 and Analysis of ...

Results Baseline and Paromomycin-stimulated rates of missense suppression suggest afunctional difference between the near- and non-cognate tRNAs Introduction of a missense mutation into the active site of an enzyme followed by  ...

Johnathan Robert Russ, 2007

Functional Studies of Rare CFTR Missense Mutations ...

By analyzing residues with multiple missense mutations, one could distinguish whether the phenotypic differences in patients are attributable to the change at the specific amino acid (e.g., arginine of 1070 codon does not tolerate changes) or ...

Kristina V. Krasnov, 2009

The Brugada Syndrome: From Bench To Bedside

Nucleotide change Amino acid change Alteration type Region Mutation phenotype G8OA R27H Missense N-terminus BrS G253A G355 Missense N- terminus BrS G461A R1 O4Q Missense N-terminus BrS n.g. K126E Missense Dl- S1 BrS n.g. ...

Charles Antzelevitch, 2008

Principles of Molecular Medicine

... Nonsense AAGATAG K174X Ex 5 Missense ACGAATG T318M Ex 6 Nonsense CAGATAG Q338X Ex 6 Nonsense CAGATAG Q356X Ex 6 Missense CGGACAG R374Q Ex 7 Missense CGAACAA R384Q Ex 7 Missense CGAAGGA R384G Ex ...

Marschall S. Runge, Cam Patterson, 2007

From Molecule to Men: Molecular Basis of Congenital ...

The molecular mechanism of inherited hypercholesterolemia 159. no. exon codon change nucleotide change type origin statusI number of patients 1 1 mer2' — »val ATG^GTG missense Netherlands het 2 2 Intron 1 nt67+l G^A splice site new ...

M. Zehender, Günter Breithardt, H. Just, 2000

THE HUMAN GENOME: A User's Guide

We would predict similar phenotypes for cases in which missense and nonsense mutations are both causing the disease via the same mechanism – loss-of- function. Thus, for many loss-of-function diseases, such as cystic fibrosis, we can see ...

R. Scott Hawley, Catherine A. Mori, 2010

Vogel and Motulsky's Human Genetics: Problems and Approaches

10.3.2.1 Mutations Affecting the Amino Acid Sequence of the Predicted Protein, but not Gene Expression Many missense mutations (i.e., nucleotide substitutions that result in an amino acid substitution) cause hereditary disease in humans.

Michael Speicher, Stylianos E. Antonarakis, Arno G. Motulsky, 2009

25 Years of p53 Research

In the p53 database both missense and nonsense mutations are found in many cancers. The missense proteins are not transcriptionally functional and so no MDM-2 protein is made in most cells. Due to the decreased abundance of the ...

Pierre Hainaut, Klas Wiman, 2007

Genetic Hearing Loss

Table 1 Reported PDS Mutations Exon Type Mutation Missense Ref. IVS1 Splice site IVS1-2A > G 35 2 Missense 85G>C E29Q 30 IVS2 Splice site IVS2-1G>A 33 3 Frameshift 279delT 39 4 Missense 314A>G Y105C 30 4 Missense 3170A ...

Patrick J. Willems, 2003

Molecular Biology: Academic Cell Update Edition

Missense Mutations May Have Major or Minor Effects When a change in the base sequence alters a codon so that one amino acid in a protein is replaced with a different amino acid, this is called a missense mutation. Overall, this is the most ...

David P. Clark, 2005

包含词语«MISSENSE»的新条目

找出国内和国际出版社所讨论的内容，以及词语missense在以下新条目的上下文中是如何使用的。

Exome sequencing identifies recessive CDK5RAP2 variants in …

This is the first time that recessive missense mutations in CDK5RAP2 are specifically associated with corpus callosum anomalies, a finding ... «Nature.com, 七月 15»

Novel mutations of NFIX gene causing Marshall-Smith syndrome or …

Two frameshift mutations and a donor-splice one caused Marshall-Smith syndrome, while two missense mutations in the DNA binding/dimerisation domain ... «Nature.com, 七月 15»

Analysis of exome sequence in 604 trios for recessive genotypes in …

An exploratory analysis restricted to nonsynonymous variants most likely to disrupt protein function (stop gain/splice annotations and missense ... «Nature.com, 七月 15»

Paired exome analysis of Barrett's esophagus and adenocarcinoma

4b,f), TP53 missense mutations were shared by all sampled tissues, including .... cohort of EAC samples, showing truncating mutations, missense mutations at a ... «Nature.com, 七月 15»

Genomic landscape of cutaneous T cell lymphoma

An asterisk highlights a previously reported gain-of-function missense mutation. (b) Structural model of the CD28-CD86 complex highlighting Phe51 and Gln77 ... «Nature.com, 七月 15»

Association analyses identify 38 susceptibility loci for inflammatory …

In contrast to the high number of SNPs tagging eQTLs, only 3 of the 38 SNPs were in high linkage disequilibrium (LD; r2 > 0.8) with known missense coding ... «Nature.com, 七月 15»

Preventing E-cadherin aberrant N-glycosylation at Asn-554 …

A new approach to CDH1 missense variants. Eur J Hum Genet 2014, e-pub ahead of print 12 November 2014; doi:10.1038/ejhg.2014.240. «Nature.com, 七月 15»

First de novo KCND3 mutation causes severe Kv4.3 channel …

... predicted impact on the encoded protein according to the refGene annotation (missense, nonsense, frame shift, inframe indels and essential splice variants). «BMC Blogs Network, 七月 15»

Peripheral blood cells from children with RASopathies show …

PTPN11 somatic missense mutations have been identified in approximately one-third of JMML cases. In this regard, analysis of the mutational ... «Nature.com, 七月 15»

Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high …

At BRCA1, 6 different mutations were identified, including 2 frameshifts, 1 nonsense and 1 missense that had been previously reported ... «BMC Blogs Network, 七月 15»