单词 SPECTRIN的词源
From spectr(e) + -in, referring to the ghosts (isolated cell membranes) of red blood cells, the source of the first known member of the class.
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1
Unexpected Complexity Involved in the Targeting and Function ...
IV: PHOSPHOINOSITIDE BINDING IS DISPENSABLE FOR p-SPECTRIN
TARGETING AND FUNCTION A) Introduction P-Spectrin is essential for the
survival of Drosophila melanogaster (Dubreuil et al., 2000). Spectrin is
ubiquitously ...
2
Structure and Dynamics of N-terminal Region of Non-erythroid ...
INTRODUCTION 1.1 Spectrin 1.1.1 Spectrin Overview Spectrins are elongated
filamentous, membrane-associated, actin-binding proteins and a member of the
spectrin superfamily, which is largely comprised of a-actinin, spectrin, dystrophin,
...
3
Mechanistic Insights Into Diversity and Organization of the ...
CHAPTER 5 ADDUCIN PROMOTES MICRON-SCALE ORGANIZATION OF P2-
SPECTRIN AT THE LATERAL MEMBRANE IN BRONCHIAL EPITHELIAL CELLS
INTRODUCTION Lateral membranes of epithelial cells are one of the most ...
4
Blood: Principles and Practice of Hematology
The N-terminal region of P-spectrin also binds actin (461- 463) and shares
sequence homology with several actin-binding proteins, including a-actinin,
dystrophin, filamin, gelation factor (ABP 120), adducin, and fimbrin. A 27-amino
acid ...
Robert I. Handin, Samuel E. Lux, Thomas P. Stossel, 2003
5
Wintrobe's Clinical Hematology
Defects of the a/3-spectrin self-association site in hereditary elliptocytosis (HE)
and hereditary pyropoikilocytosis (HPP). A model of the triple-helical spectrin
repeats that constitute the a/3-spectrin self-association site is shown. Limited
tryptic ...
6
Cell Movements: From Molecules to Motility
Dimers of spectrin associate into a tetramer with a length of 200 nm, which is the
form found in the erythrocyte cortex. The ends of spectrin tetramers in the red
blood cell cortex are linked to short lengths of actin filament (each containing
about ...
7
Molecular Biology of Membrane Transport Disorders
The interactions of protein 4.1 with actin and spectrin are also regulated by Ca2+-
calmodulin,42-44 primarily via the binding of calmodulin to protein 4. 1.43 At
micromolar concentrations of Ca2+, formation of the ternary complex is inhibited.
Spectrin I is composed oftwo large subunits of approximately 280 (α) and 246
kDa (β). The simplest form of spectrin is an antiparallel αβ heterodimer; however,
on the cytoplasmic surface ofthe erythrocyte membrane, it is an (αβ)2 tetramer, ...
9
Excitatory Amino Acids: Ten Years Later
These are: a-actinin-2 and spectrin (two actin -bm ding proteins), tubulin and
CaMKH. These proteins and their interacting associates are the prime candidates
to play a role in spine plasticity while the other PSD proteins are likely to
contribute ...
Lechoslaw Turski, D. D. Schoepp, Esper A. Cavalheiro, 2001
10
Cytoskeleton in Specialized Tissues and in Pathological States
the structural proteins——ot and β spectrin, which comprise 25% of the rbc
protein, and actin; the two integral membrane proteins—band 3 (the anion
exchanger) and glycophorin C; and the membrane-structural protein linkers—-
band 4.1, ...
J.E. Hesketh, I.F. Pryme, 1996
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High-throughput sequencing of the synaptome in major depressive …
SPTBN1, also known as βII-spectrin, is a scaffolding protein that binds the actin cytoskeleton to stabilize axonal projections and induce neurite formation. «Nature.com, 七月 15»
Public Release: 27-Apr-2015 International research team discovers …
They hypothesized that the parasite protein/cell membrane interaction caused spectrin, a cytoskeletal protein that provides a scaffold for the cell membrane, ... «EurekAlert, 四月 15»
A rare variant in MCF2L identified using exclusion linkage in a …
At the N-terminus, a Sec14 (Sec14p-like lipid binding domain) and Spectrin repeats (SPEC) are located. At the C-terminus, a SH3 (Src homology 3 domain of ... «Nature.com, 四月 15»
New blood test could indicate long-term severity of concussions
That's short for calpain-cleaved αII-spectrin N-terminal fragment. How could this tiny protein potentially help diagnose millions of concussion sufferers per year? «Newsworks.org, 一月 15»
Blood Test Tells How Long Concussion Symptoms Will Last
A protein fragment called SNTF was a good candidate. SNTF is part of a structural protein called spectrin in neurons. When neurons are stretched and deformed, ... «Scientific American, 一月 15»
New Test For Concussion Severity
... calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms ... «AskMen, 十一月 14»
Researchers say beautiful protein may be nasty to bacteria
EzrA displayed an unusual and beautiful semi-circular structure with similarities to the ubiquitous proteins known as spectrins, which are involved in the ... «HealthCanal.com, 十一月 14»
Alcoholism's Molecular Effects Identified
... eosin staining and light microscopy on the prefrontal cortex, the researchers discovered deficiencies in α- and β-tubulin of the cytoskeleton and spectrin β II. «HCPLive, 八月 14»
Abusive Coaches May Foster Cheating in Sports
Researchers have found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly ... «Counsel & Heal, 七月 14»
Solitary acoustic waves observed to propagate at a lipid membrane …
Adding channels, proteins, subsurface actin or spectrin, and a contiguous internal cytoskeleton will be even more illuminating. If we can then myelinate these ... «Phys.Org, 六月 14»
