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ATP ADP H C H O C H OH C H OH C HO H C H OH C H O P Hexokinase Glucokinase Glucose 6-phosphate D -Glucose H C H OH C H OH C H OH C HO H C H OH C H O Concentration of fasting blood glucose Glucokinase Vmax ...
Richard A. Harvey (Ph. D.), Richard A. Harvey, Denise R. Ferrier,
2011
2
Allosteric Regulatory Enzymes - 183페이지
Human hexokinase III has substrate inhibition by glucose. Data from Palma et al. 235 This has been demonstrated for hexokinase III from pig239 and from humans.235 For an erythrocyte enzyme, positive cooperativity for glucose appears ...
3
Cell Growth And Oncogenesis - 12페이지
Conclusions and future directions Recent studies on the overexpression and regulation of hexokinase in tumor cells provide new insights about its role in maintaining the highly glycolytic phenotype, and new insights about the mechanisms ...
Peter Bannasch, S. Papa, Darja Kanduc,
1998
4
Glucose Metabolism in the Brain - 7페이지
If glycolysis were not regulated, metabolism of all available glucose that entered the brain would simply consume glucose and ATP, trap phosphate as triose-P, and produce lactate. Major sites for control of glycolytic flux are hexokinase, ...
5
Comparative Animal Biochemistry - 523페이지
three isoenzymes by its smaller size (50 kDa), its much lower affinity for glucose and other substrates, and its reduced sensitivity to the inhibitory effect of Glc-6-P. At substrate concentrations of about 100 mmol/1, hexokinase D metabolizes ...
6
Cancer: A Dysmethylation Syndrome ? - 43페이지
Hexokinase: the. first. enzyme. of. glycolysis,. its. control. by. oxidative. mitochondrial. metabolism. We have already analyzed the metabolic features of tumors, the pyruvate kinase "bottle neck" and the jammed enzymatic switches. We shall ...
Maurice Israël, Laurent Schwartz,
2005
7
Advances in Trematode Biology - 324페이지
The first enzyme of the pathway, hexokinase, controls the entry of glucose into glycolysis and is important in the regulation of carbohydrate degradation. Hexokinase is reported to be "rate limiting" in S. mansoni glucose metabolism.104-105 ...
Bernard Fried, Thaddeus K. Graczyk,
1997
8
Mitochondria and Cancer - 110페이지
These agents included not only G-6-P and the amphipathic compound, clotrimazole, but also the N-terminal oligopeptide of hexokinase II. This implies that the inhibitory effect of hexokinase II was not due solely to the occupation of the site that ...
Keshav Singh, Leslie Costello,
2009
9
Integration and Control of Metabolism - 41페이지
Hexokinase/Glucokinase. Hexokinase, which is found in most tissues except liver and pancreas, has a low Km (0.10 mM) for glucose compared to the blood glucose concentration of 5 mM. It is strongly inhibited by the product of its reaction, ...
Naa Adamafio, Laud Okine, Jonathan Adjimani,
2005
10
PET: Molecular Imaging and Its Biological Applications - 283페이지
The reason is that the next reaction in the glycolytic pathway after hexokinase is the freely reversible iso- merization of glucose-6-phosphate to fructose-6-phosphate, in effect, a rearrangement of the carbonyl group from C-l to C-2.