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1
Diseases of the Kidney and Urinary Tract - 2132페이지
PHARMACOKINETICS OF LOOP DIURETICS Bioavailability 9% Healthy Renal disease Liver disease CHF Furosemide 10–100 1.5–2 2.8 2.5 2.7 Bumetanide 80–100 1 1.6 2.3 1.3 Torsemide 80–100 3–4 4–5 8 6 (Data adapted from: Brater ...
diuretics. Changes in the composition of the urine induced by loop diuretics are shown in Figure 22.6. [Note: Loop diuretics increase the Ca2+ content of urine, whereas thiazide diuretics decrease the Ca2+ concentration of the urine.
Richard Finkel (PharmD.), Michelle Alexia Clark, Luigi X. Cubeddu,
2009
3
Principles of Pharmacology: The Pathophysiologic Basis of ...
The so-called loop diuretics act at the TAL of the loop of Henle. These agents reversibly and competitively inhibit the Na"-K"-2Cl cotransporter NKCC2 in the apical (luminal) membrane of TAL epithelial cells (Fig. 20-7). In addition to the primary ...
The secretion of loop diuretics is reduced to the same extent. In view of this it is easily seen that renal ischemia compromises the secretion and hence the action of loop diuretics. In addition, ischemia may quickly diminish NaCl reabsorption in ...
Rainer F. Greger, H. Knauf, E. Mutschler,
2012
5
Renal and Electrolyte Disorders - 71페이지
The loop diuretics—ethacrynic acid, furosemide, bumetanide, and torsemide—are the most potent diuretic agents available. The inhibition by these agents of active sodium chloride transport in the medullary ascending limb of the loop of Henle ...
6
Nursing Pharmacology Made Incredibly Easy!
Loop. diuretics: Furosemide. Actions Indications • Inhibits sodium and chloride reabsorption in • Acute pulmonary edema the ascending loop of Henle, thus increasing • Edema renal excretion of sodium, chloride, and water • Hypertension ...
Lippincott Williams & Wilkins,
2008
Loop diuretics are a class of diuretics widely used and occasionally implicated in ototoxicity. They are organic compounds that exert potent saliuretic effects by blocking the reabsorption of sodium and chloride from the epithelial cells in the ...
Peter S. Roland, John A. Rutka,
2004
8
Pharmacotherapeutics for Advanced Practice: A Practical ...
Diuretics There are five classes of diuretics: carbonic anhydrase inhibitors (which are not used for hypertension because of their weak antihypertensive effects), thiazides. thiazide-like diuretics, loop diuretics, and potassium-sparing diuretics.
Virginia Poole Arcangelo, Andrew M. Peterson,
2006
9
Pediatric Nephrology - 1207페이지
Although rarely used alone, quinazolones may be used concurrently with diuretics acting at the loop of Henle to increase solute delivery to the distal nephron. Loop diuretics act primarily in the thick ascending limb of the loop of Henle by ...
Ellis D. Avner, William Harmon, Patrick Niaudet,
2004
10
High Blood Pressure for Dummies - 207페이지
Loop diuretics don't raise the cholesterol the way that thiazide diuretics do (a definite advantage), but they're not as effective in reducing disease and death caused by high blood pressure. Loop diuretics reduce not only sodium and chloride ...