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2.2 Prodrug 화 수식 을 이용한 흡수 촉진 홉수 장벽 의 극복 을 목적 으로 한 prodrug 의 대부분 은 소화관 홉수 를 대 상 으로 하고 있다 . 합성 penicillin 계 의 arnpicillin 은 경구 제로 서도 사용되고 있는데 약물 분 자가 수용성 을 나타 내기 때문에 ...
2
Hydrolysis in Drug and Prodrug Metabolism - 528페이지
N. M0rk. H. Bundgaard, 'Phenyl Carbamates of Amino Acids as Prodrug Forms for Protecting Phenols against First-Pass Metabolism'. Int. J. Pharm. 1992. <S7. 253-261. [ 1 62] I. den Daas. P. de Boer, P. G. Tepper, H. Rollema, A. S. Horn, ...
Bernard Testa, Joachim M. Mayer,
2003
3
Enzyme-Prodrug Strategies for Cancer Therapy
INTRODUCTION Antibodydirected enzyme prodrug therapy (ADEPT) is a strategy for treating cancer that combines antibody specificity with enzymatic catalysis to deliver drugs selectively to tumor sites. In this approach a conjugate consisting ...
Roger G. Melton, Richard J. Knox,
2012
4
Prodrugs: challenges and rewards. P. 1 - 454페이지
A prodrug approach becomes of even greater interest when multiple properties of the parent agent can be improved at the same time. For example, when a peptide is conjugated as a promoiety (part of the prodrug that is attached to the parent ...
Valentino J. Stella,
2007
5
An Introduction to Drug Design - 55페이지
This is an example of site- specific drug delivery and presumably is brought about by the prodrug entering the red blood cells and the actions of thioesterases and thiols give rise to the charged thiamine molecule, which is virtually unable to ...
S. N. Pandeya, J. R. Dimmock,
1997
6
Prodrug Design: Perspectives, Approaches and Applications ...
Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs ...
Vivekkumar K Redasani, Sanjay B. Bari,
2015
7
Gibaldi's Drug Delivery Systems in Pharmaceutical Care - 126페이지
Prodrug. Design. Prodrugs are designed to overcome barriers to a drug's optimal delivery and therapeutic usefulness. These barriers may be presented in any of the three phases of drug action, namely, the pharmaceutical phase, the ...
Mary Lee, Archana Desai,
2007
8
Preclinical Development Handbook: ADME and ... - 340페이지
Although there is no universal definition for a prodrug itself, and the definition may vary, generally prodrugs can be defined as pharmacologically inert chemical derivatives that can be converted in vivo to active drug molecules, enzymatically or ...
9
Textbook of Drug Design and Discovery, Third Edition - 413페이지
The regulatory authorities consider a prodrug of a lead as a NCE. Thus, already performed studies (for example toxicity studies) using such a lead have to be repeated in case the prodrug is to be introduced in the development programme.
Tommy Liljefors, Povl Krogsgaard-Larsen, Ulf Madsen,
2002
10
A PEPTIDE PRODRUG STRATEGY FOR INCREASING ORAL ...
A peptide prodrug strategy designed to target the intestinal peptide transporter to increase absorption and then to target the cytosolic prolidase as the prodrug converting enzyme to release the drug from the peptide prodrug inside the cell ...
包含词语«프로드러그»的新条目
找出国内和国际出版社所讨论的内容，以及词语
프로드러그在以下新条目的上下文中是如何使用的。
유럽, 길리어드 에이즈치료제 젠보야 승인
TAF는 길리어드의 TDF치료제인 '비리어드'의 투여용량을 10분의 1로 줄이면서도 항바이러스효과가 비슷하게 나타나는 '테노포비르'의 표적 프로드러그(prodrug) ... «헬스코리아뉴스, 十一月 15»
명문제약, 프로드러그 소염진통제 '록소프로펜정' 발매
주성분인 록소프로펜나트륨은 위장관에서 흡수가 빨라 소염진통효과가 신속하게 나타나며, 생체 내 반응에 의해서만 약효가 발현되는 프로드러그(prodrug)로서 위장 ... «헤럴드경제, 七月 14»
[이달의 과학기술자상] 김종승 고려대 교수
이를 '프로드러그(prodrug)' 형태로 만들었다. 표적지향체는 약물전달 체계에서 표적부위에 선택적으로 작용해 약물의 흡수를 돕는 물질이다. 또 프로드러그는 약물에 ... «서울경제, 三月 13»