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1
Management of Lipids in Clinical Practice - Page 188
Third, the VA-HIT population was older and included more diabetic patients. Fourth, approximately 2% of the placebo group and 1% of the gemfibrozil group were given open-label lipid medication in the VA-HIT, whereas in the BIP study, 15% ...
Neil J. Stone, Conrad B. Blum,
2008
2
Peripheral Vascular Disease: Basic Diagnostic and ... - Page 86
The Veterans Administration HDL Intervention Trial (VA-HIT) enrolled 2,531 men with known CHD, low HDL-C, and normal LDL-C levels; approximately 25% of the men who fit these entry criteria had diabetes, whereas 50% had either type 2 ...
3
Triglycerides and Cholesterol Research - Page 10
Results from the VA-HIT. Cox regression analysis for the hazard ratios (HR) as calculated for each 1 mg/dl increase in o-1 and HDL-C levels in predicting subsequent cardiovascular events (n=398) in VA-HIT (n=1495). HR for each 1 mg/dl ...
4
Comprehensive Cardiovascular Medicine in the Primary Care ...
VA-HIT, 769 diabetics with known heart disease were randomized to either placebo or gemfibrozil 1,200 mg daily for 5 years. Baseline LDL-cholesterol and triglyceride levels were similar to those seen in the FIELD trial while HDL-cholesterol ...
Peter P. Toth, Christopher P. Cannon,
2010
5
Atherosclerosis: Molecular and Cellular Mechanisms - Page 113
Fibrate treatment reduced the incidence of coronary heart disease in both the HHS [89] and VA-HIT trials [93]. Of note, BIP and VA-HIT subjects were not on statins, LDL-cholesterol-lowering drugs. Altogether, results from these three studies ...
Sarah Jane George, Jason Johnson,
2010
6
Atherosclerosis: Diet and Drugs - Page 547
Gemfibrozil also produced a significant increase in HDL3-C in the secondary prevention trial VA-HIT which was related to a reduction of CHD events (Robins et al. 2001). VA-HIT selected men with low HDL-C levels (average 0.82 mmol/l) and ...
Arnold von Eckardstein,
2006
7
Comprehensive Management of High Risk Cardiovascular Patients
Prior to the FIELD study, the VA-HIT provided the largest sample of diabetic patients treated with a fibric acid derivative. In VA-HIT, 769 diabetics with known heart disease were randomized either placebo or gemfibrozil 1200 mg daily for five ...
Antonio M. Gotto, Peter P. Toth,
2006
8
Cardiovascular Therapeutics: A Companion to Braunwald's ...
In patients with CHD and low HDL, the Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial (VA-HIT) study31 shows that gemfibrozil compares favorably with statin therapy, using a number needed to treat (NNT) to prevent ...
9
Landmark Papers in Cardiovascular Medicine - Page 37
Veterans. Administration. HDL. Intervention. Trial. (VA-HIT). Rubins HB, Robins SJ, Collins D, Fye CL, Anderson JW, Elam MB. Gemfibrozil for the secondary prevention of coronary heart disease in men With low levels of high-density ...
Aung Myat, A. H. Gershlick, Tony Gershlick,
2012
10
Peroxisome Proliferator Activated Receptors: From Basic ... - Page 85
Perhaps most intriguing is the possibility that the benefits seen in the HDL Intervention Trial (VA-HIT) [35] were in fact due to gemfibrozil activity on PPARa as opposed to, or in conjunction with, its lipid effects [36]. VA-HIT investigators asked if ...
J.-C. Fruchart, Antonio M. Gotto Jr., Rodolfo Paoletti,
2002