«ガンマ‐セクレターゼ»に関連する日本語の本
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1
Recent Advances In Retinal Degeneration - 316 ページ
elements are themselves regulated by a variety of growth factors including VEGF. Little is known about the mechanism by which γ-secretase regulates angiogenesis but to date emphasis has largely been placed on the Notch signalling system ...
Robert E. Anderson, Matthew M LaVail, Joe G. Hollyfield,
2007
2
Amyloid Precursor Protein: A Practical Approach - 67 ページ
Complex N-linked glycosylated nicastrin associates with active γ-secretase and undergoes tight cellular regulation. J. Biol. Chem. 277, 35113, 2002. Leem, J.Y. et al. Presenilin 1 is required for maturation and cell surface accumulation of ...
Weiming Xia, Huaxi Xu,
2004
3
Basic Neurochemistry: Principles of Molecular, Cellular, ... - 824 ページ
Not only are Presenilin 1 and 2 (PSEN1 and PSEN2) often mutated in patients with familial AD, but the role of presenilins as components of the γ-secretase proteolytic complex also makes them essential for the production of Aβ peptides from ...
Scott Brady, George Siegel, R. Wayne Albers,
2011
4
Neurobiology of Alzheimer's Disease - 396 ページ
All the known γ-secretase substrates are type I membrane proteins and are cleaved in their TM domains in a PS-dependent manner. Cleavage of these substrates can be blocked by several well-characterized γ-secretase inhibitors. For APP ...
David Dawbarn, Shelley J. Allen,
2007
5
Frontiers in CNS Drug Discovery - 128 ページ
γ-Secretase Inhibitors γ-secretase is the second protease that participates in APP proteolysis and Aβ1-42 production in the amyloidogenic pathway. γ-secretase is an aspartyl protease that belongs to the intramembrane-cleaving protease ...
Atta-ur Rahman, M. Iqbal Choudhary,
2010
6
Lipids and Cellular Membranes in Amyloid Diseases
secretase [43]. The enzymes that catalyze the ectodomain shedding of γ-secretase substrates include members of the disintegrin and metalloprotease (ADAM) family, β-site APP cleaving enzymes (BACE1), and matrix metalloproteases ...
7
Mapping the Progress of Alzheimer’s and Parkinson’s Disease
The resulting CTFβ is the immediate precursor for the intramembraneous γ-secretase cut. This cleavage is facilitated by the presenilins, PS1 and PS2, and there is evidence that presenilins themselves could be unusual aspartyl proteases, ...
Yoshikuni Mizuno, Abraham Fisher, Israel Hanin,
2002
8
Alzheimer's Disease: Advances in Genetics, Molecular and ... - 19 ページ
or β-secretase (amyloidogenic pathway) within the lumenal domain, resulting in the shedding of nearly the entire ectodomain and ... The minimal components of γ-secretase include presenilin-1 or -2 (PS1 or PS2), nicastrin, APH-1, and PEN-2 ...
Sangram S. Sisodia, Rudolph E. Tanzi,
2007
9
Pathy's Principles and Practice of Geriatric Medicine
APP processing by α-secretase is a non-amyloidogenic pathway, because the α-secretase cleavage site is within the Aβ sequence of APP. Enhanced ... LY450139 dihydrate, a γ-secretase inhibitor, inhibits Aβ formation in vitro and in vivo.
Alan J. Sinclair, John E. Morley, Bruno Vellas,
2012
10
Pharmacological Mechanisms in Alzheimer's Therapeutics - 117 ページ
γ-Secretase is a complex consisting of the presenilins, nicastrin and anterior pharynx defective-1 (Aph-1), and presenilin enhancer-2 (Pen-2), with the presenilins constituting the catalytic site of the complex (Haass, 2004). Presenilin-1 and ...
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固形がん治療に「PF-03084014」、がん細胞増やすタンパク質の「切れる …
... 関わっている。この場合、ノッチが、「ガンマセクレターゼ」という酵素で切られると、がん細胞に「増えろ」という信号が送られる。 今回検証が行われた抗がん剤「PF-03084014」は、ガンマセクレターゼの働きを邪魔して、がんに「増えろ」と指令できなくする薬だ。 «Medエッジ, 1月 15»
難聴の聴力改善、マウスで成功
Ｎｏｔｃｈ阻害剤には低濃度で高い誘導効率をもつ薬剤（ここではガンマセクレターゼ阻害剤）を選択した。まずこれを体外投与し有毛細胞数の回復と支持細胞の減少を確認、支持細胞から新たな有望細胞が作り出されていることを検証した。 次いで過大音曝露で有 ... «QLifePro医療ニュース, 2月 13»
アルツハイマーの謎と原因
ところが、正常な人は、アミロイドベータタンパク質の中央部分をアルファセクレターゼという酵素が切断することによって “犯人” が ... つまり、この前駆体を切断する3種類の酵素のうち、ベータセクレターゼとガンマセクレターゼに比較して、アルファセクレターゼの ... «JBpress, 3月 09»