CO OZNACZA SŁOWO AZATHIOPRINE
Azathioprine
Azathioprine jest lekiem immunosupresyjnym stosowanym w przeszczepach narządów i chorobach autoimmunologicznych i należy do klasy chemicznej analogów purynowych. Syntetyzowany pierwotnie jako lek przeciwnowotworowy i prolek merkaptopuryny w 1957 r., Od ponad 50 lat jest szeroko stosowany jako środek immunosupresyjny. Azathioprine działa jako prolek dla merkaptopuryny, hamując enzym wymagany do syntezy DNA. W ten sposób najsilniej wpływa na komórki proliferujące, takie jak komórki T i komórki B układu odpornościowego. Głównym niepożądanym działaniem azatiopryny jest zahamowanie czynności szpiku kostnego, które może zagrażać życiu, zwłaszcza u osób z deficytem genetycznym enzymu S-metylotransferazy enzymu tiopurynowego. Jest również wymieniona przez Międzynarodową Agencję Badań nad Rakiem jako rakotwórcza grupy 1. Azathioprine jest produkowany przez wielu producentów pod różnymi markami. To jest w Liście Podstawowych Leków Światowej Organizacji Zdrowia, w liście najważniejszych leków niezbędnych w podstawowym systemie opieki zdrowotnej.
Definicja słowa azathioprine w słowniku
Definicja azatiopryny w słowniku jest syntetycznym lekiem, który tłumi normalne odpowiedzi immunologiczne organizmu i jest podawany doustnie podczas i po przeszczepie narządu, a także w niektórych rodzajach chorób autoimmunologicznych. Wzór: C9H7N7O2S.
KSIĄŻKI POWIĄZANE ZE SŁOWEM «AZATHIOPRINE»
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azathioprine oraz krótkie ich fragmenty w celu przedstawienia kontekstu użycia w literaturze.
1
Current Therapy in Neurologic Disease
Because the beneficial effects of azathioprine may take more than 6 months to
appear, the combination of azathioprine and steroids or azathioprine and IVIg
affords the relatively rapid onset of immunosuppression produced by the steroids
or ...
Richard Tidball Johnson, John W. Griffin, Justin C. McArthur,
2006
2
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal ...
Intrauterine growth restriction also has been reported, but this effect may have
been a consequence of multiple factors, one of which was azathioprine, working
in combination. Taken in sum, however, the evidence suggests that the maternal
...
Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe,
2011
3
Chemical Stability of Pharmaceuticals: A Handbook for ...
4. cx>. C9H7N702S mol. wt . 277.3 Forms Available Free acid ( az a t h 1 o pr i ne
) ; sodium a z a t h i op r i ne , Na( C9H6N702S) . Physical Properties
Azathioprine melts at approximately 240°C (1). Solubility: 0.130 mg/mL in water
at 25°C (2) ...
Kenneth Antonio Connors,
1986
4
Pediatric Gastrointestinal Disease: Pathophysiology, ...
or colonic resection.162 Another study suggested that aza- thioprine heals
recurrent ileitis developing in the neoter- minal ileum.163 Azathioprine also has
been widely used in the therapy of inflammatory bowel disease. The results
suggest ...
5
Advanced Therapy of Inflammatory Bowel Disease: Ulcerative ...
CONCLUSION In summary, the immunomodulators 6-MP and azathioprine are
some of the best therapies currently available for the treatment of chronic UC.
They are usually well tolerated and easy to dose. Unfortunately, many clinicians ...
Theodore M. Bayless, Stephen B. Hanauer,
2011
6
Textbook of Atopic Dermatitis
o Subjects receiving azathioprine 2.5 mg/kg/day (n = 18) followed by placebo (n
= 1 1 ) 0 Subjects receiving placebo (n = 17) followed by azathioprine (n = 15)
Figure 18.4 Mean SASSAD scores during treatment for 3 months with
azathioprine ...
Sakari Reitamo, Thomas A. Luger, Martin Steinhoff,
2008
7
A Manual of Adverse Drug Interactions
In the treatment of psoriatic arthritis there is the clinical belief that azathioprine is
more effective for the arthritic element and methotrexate for the dermatological
manifestations. In myasthenia gravis where thymectomy is not advisable ...
J.P. Griffin, P.F. D'Arcy,
1997
8
European Drug Index: European Drug Registrations, Fourth Edition
Azathioprinum 50mg (L04AX01) (BG) Azathioprine (Generics) tab.:
Azathioprinum 50mg(L04AX01)(BG) Azathioprinetablets 50 mg Azathioprine (
L04AX01)(RUS) Azathioprine 50mg(Medexport V/O Moscow) tab.: Azathioprinum
(L04AX01) ...
9
Kidney Transplantation - Principles and Practice
Azathioprine and 6-mercaptopurine are thiopurines, and azathioprine is an
imidazolyl derivative of 6-mercaptopurine. Azathioprine is metabolized in the liver
before becom- ing active. One metabolic pathway is through its con- version to ...
Peter Morris, Stuart J. Knechtle,
2013
10
Concepts in Immunology and Immunotherapeutics
The therapeutic use of azathioprine in renal transplantation. Pharmacotherapy.
1987; 7(5):165–177. 96. Van Scoik KG, Johnson CA, Porter WR. The
pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and
azathioprine.
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «AZATHIOPRINE»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
azathioprine w wiadomościach.
Kansas senior's battle with rare disease and how to help. What is …
Immunosuppressant drugs, such as azathioprine and methotrexate, may reduce inflammation in people who do not respond well to prednisone ... «Outbreak News Today, Lip 15»
SIMPONI® Receives European Commission Approval for Treatment …
... including corticosteroids and 6-mercaptopurine or azathioprine, or who are intolerant to or have medical contraindications for such therapies. «PharmiWeb.com, Lip 15»
Pfizer Announces FDA Acceptance for Review of New Drug …
Use of XELJANZ in combination with biologic DMARDs or potent immunosuppressants, such as azathioprine and cyclosporine is not ... «MarketWatch, Lip 15»
Necrotizing Myopathy: Are Statins to Blame?
Treatment of these patients has included prednisone, azathioprine, methotrexate, rituximab, and intravenous immunoglobulin (IVIG). «MedPage Today, Lip 15»
Psoriatic Arthritis Pharmacotherapy Market Segment Forecasts up to …
While immunosuppressant helps to control the immune system including azathioprine and cyclosporine. TNF-α inhibitors assist reducing pain, ... «CSO Australia, Lip 15»
As PGx Program Grows, Vanderbilt Hoping to Expand Reported …
... at Vanderbilt have TPMT alleles that placed them at risk for responding poorly to thiopurines — drugs such as azathioprine, mercaptopurine, ... «GenomeWeb, Cze 15»
mTOR inhibitor versus mycophenolic acid as the primary …
Since mycophenolic acid (MPA) was introduced into solid organ transplantation, it has largely replaced azathioprine (AZA) as the ... «BMC Blogs Network, Cze 15»
EU approves Simponi to treat non-radiographic axial spondyloarthritis
... including corticosteroids and 6-mercaptopurine or azathioprine, or who are intolerant to or have medical contraindications for such therapies. «pharmabiz.com, Cze 15»
Infections, age and medications linked to death in patients with …
... followed by intravenous glucocorticoids in 64%, cyclophosphamide in 43%, pulse cyclophosphamide in 49% and azathioprine in 25%. «Healio, Cze 15»
Early treatment best for rheumatoid arthritis
Commonly prescribed DMARDs include methotrexate, sulfasalazine, penicillamine, leflunomide, azathioprine, cyclosporin and mycophenolate. «Stuff.co.nz, Cze 15»