CO OZNACZA SŁOWO MELPHALAN
Melphalan
Melphalan jest lekiem chemioterapeutycznym należącym do klasy środków alkilujących musztardę azotu. Środek alkilujący dodaje do grupy DNA grupę alkilową. Przyłącza grupę alkilową do guaniny DNA, przy atomie azotu nr 7 pierścienia imidazolowego. W innym przypadku znany jako Musztarda L-fenyloalanina lub L-PAM, melfalan jest pochodną fenyloalaniny mechloretaminy.
Definicja słowa melphalan w słowniku
Definicja melfalanu w słowniku to lek, C13H18Cl2N2O2, stosowany w leczeniu białaczki szpikowej.
KSIĄŻKI POWIĄZANE ZE SŁOWEM «MELPHALAN»
Poznaj użycie słowa
melphalan w następujących pozycjach bibliograficznych Książki powiązane ze słowem
melphalan oraz krótkie ich fragmenty w celu przedstawienia kontekstu użycia w literaturze.
1
Principles and Practice of Gynecologic Oncology
It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine. Melphalan
is water insoluble and previously was only commercially available in a 2-mg
tablet form. However, a parenteral formulation was approved by the FDA in 1993.
2
The Chemotherapy Source Book
Melphalan has been reported to cause HSRs primarily when administered
intravenously (185,186). Oral melphalan has produced only a rare instance of
reaction, whereas i.v. melphalan (despite concurrent prednisone administration)
...
Michael Clinton Perry,
2008
3
Thomas' Hematopoietic Cell Transplantation
Modulation of cytostatic efficacy of melphalan by glutathione: mechanisms and
efficacy. Chem Biol Interact 2002; 140: 93–107. 175. Schecter RL, Woo A, Duong
M, Batist G. In vivo and in vitro mechanisms of drug resistance in a rat mammary ...
Frederick R. Appelbaum, Stephen J. Forman, Robert S. Negrin,
2011
4
Principles and Practice of Gynecologic Oncology
Melphalan Chemistry. Melphalan (Alkeran, L-phenylalanine mustard, L-PAM) is a
phenylalanine derivative of nitrogen mustard that acts as a bifunctional alkylating
agent. Melphalan is FDA approved for the chemotherapy of patients with ...
Richard R. Barakat, Maurie Markman, Marcus Randall,
2009
5
Blood and Marrow Stem Cell Transplantation: Principles, ...
Melphalan. Pharmacology Melphalan is a bifunctional alkylating agent with
significant activity against multiple myeloma. Melphalan also exhibits high single-
agent activity against testicular and ovarian carcinoma as well as certain
sarcomas.
Marie Bakitas Whedon, Debra Wujcik,
1997
6
Multiple Myeloma: Translational and Emerging Therapies
This exciting new text, edited by lauded authorities on the topic, stands as the only available reference to assemble, review, and synthesizes the latest studies on translational therapies and clearly explains the impact of molecular ...
Kenneth C. Anderson, M. Ghobrial Irene,
2007
7
The AARP Guide to Pills: Essential Information on More Than ...
What are melphalan tablets? MELPHALAN (Alkeran® ) is a type of chemotherapy
for treating cancer. Melphalan interferes with cell growth and treats cancers of the
ovaries and bone marrow. Generic melphalan tablets are not yet available.
MaryAnne Hochadel, Jerry Avorn,
2007
8
Blood and Marrow Stem Cell Transplantation: Principles, ...
Melphalan, an alkylating agent, is a derivative of nitrogen mustard. Although
myelosuppres- sion is the most common side effect, anorexia, nausea, vomiting,
stomatitis, hemorrhagic cystitis, and transaminitis may occur acutely. Melphalan (
150 ...
Susan Ezzone, Kim Schmit-Pokorny,
2007
9
Malignant Liver Tumors: Current and Emerging Therapies
Regional delivery of high dose melphalan has been demonstrated to be safe and
effective in stage IV disease confi ned to the liver for several different types of
cancer. Experience has demonstrated that IHP using melphalan alone or in ...
Pierre-Alain Clavien,
2011
10
Regional Therapeutics for Advanced Malignancies
00 C O .5 U G) (I) Table 1 Regimen, response rates and response assessment
method for published series of isolated limb perfusion in sarcoma 9 N C/PD 0%
64% Hill (1993)36 TNF + Melphalan 100% 0% Clinical Santinami (1996)” TNF +
...
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «MELPHALAN»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
melphalan w wiadomościach.
Delcath Announces Pricing Of Public Offering
Our proprietary Melphalan Hydrochloride for Injection for use with the Delcath Hepatic Delivery System (Melphalan/HDS) is designed to ... «PharmiWeb.com, Lip 15»
Roth Affirms Ligand Pharma (LGND) at 'Buy'; Promacta Q2 Revenue …
CE-Melphalan's (Evomela) PDUFA date is October 23, 2015. Internally, we believe a key driver will be from LGD-6972 (glucagon receptor ... «StreetInsider.com, Lip 15»
Momentum Stocks- Exelixis, Inc. (NASDAQ:EXEL), Delcath Systems …
... of Orphan Products Development or OOPD has decided Orphan Drug Designation for melphalan for the treatment of cholangiocarcinoma. «StreetWise Report, Lip 15»
Stocks In Momentum- The Boeing Company (NYSE:BA), Lockheed …
... of Orphan Products Development or OOPD has decided Orphan Drug Designation for melphalan for the treatment of cholangiocarcinoma. «StreetWise Report, Lip 15»
FDA grants orphan drug designation to melphalan for … - Healio
The FDA granted orphan drug designation to melphalan for the treatment of patients with cholangiocarcinoma, according to a press release ... «Healio, Lip 15»
CASI Pharmaceuticals (CASI) Brings ZEVALIN to Hong Kong
In addition to ZEVALIN, the Company has exclusive marketing rights in greater China to MARQIBO® and EVOMELA™ (CE-Melphalan HCl) for ... «StreetInsider.com, Lip 15»
Adaptimmune Therapeutics (ADAP) Announces Publication of T …
After autologous stem cell collection, patients were conditioned with high-dose melphalan followed two days later by autologous stem cell ... «StreetInsider.com, Lip 15»
Thalidomide As Effective As Lenalidomide in Combo Regimen for …
Overall response rates, progression-free survival, and overall survival are similar when comparing melphalan, prednisone, thalidomide ... «Cancer Therapy Advisor, Lip 15»
Adaptimmune's NY-ESO-1 TCR-engineered T-Cells Demonstrate …
After autologous stem cell collection, patients were conditioned with high-dose melphalan followed two days later by autologous stem cell ... «PharmiWeb.com, Lip 15»
Donor-derived constitutional chromosomal abnormalities after …
Preparative regimens were either busulfan/fludarabine or fludarabine/melphalan. Two patients received myeloablative preparative regimens. «Nature.com, Lip 15»