KSIĄŻKI POWIĄZANE ZE SŁOWEM «RIBONUCLEOTIDE»
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1
Ribonucleotide Reductase
Structural characterization of the peroxodiiron(III) intermediate generated during
oxygen activation by the W48A/D84E variant of ribonucleotide reductase protein
R2 from Escherichia coli. Biochemistry, 42, 13269-13279. [172] Rova U, Adrait A,
...
Kristoffer Andersson, 2008
2
Contribution of the Pseudomonas Aeruginosa Class II and ...
Table 1 A. Comparison of the NrdAB and NrdDG RNR amino acid residues of E.
coli and/5, aeruginosa strain P AO 1 28 Table IB. Amino acid alignments of the
NrdAB ribonucleotide reductases from E.coli and P. aeruginosa PAOl 29 Table
1C.
3
Synthesis and Evaluation of Inhibitors of Glycinamide ...
The three enzymes most studied as targets for antifolate inhibition are DHFR,
thymidylate synthase (TS), and glycinamide ribonucleotide transformylase (GAR
Tfase). GAR Tfase, a trifunctional protein, catalyzes the third step in a series of
ten ...
Jessica K. DeMartino, 2008
4
An Investigation of Acetobacter Aceti ...
Mueller, E. J., Meyer, E., Rudolph, J., Davisson, V. J., and Stubbe, J. (1994) N5-
carboxyaminoimidazole ribonucleotide: Evidence for a new intermediate and two
new enzymic activities in the de novo purine biosynthetic pathway of Escherichia
...
Charles Zoltan Constantine, 2009
5
Lehninger Principles of Biochemistry
glutaredoxin, which then transfers the reducing power to ribonucleotide
reductase (Fig. 22-39). Ribonucleotide reductase is notable in that its reaction
mechanism provides the best-characterized example of the involvement of free
radicals in ...
Albert L. Lehninger, David L. Nelson, Michael M. Cox, 2005
This essential reaction is catalyzed by the enzyme ribonucleotide reductase.
Deoxyribonucleotides are highly specialized metabolites and serve only as
building blocks for DNA. Their concentrations are very low in nongrowing cells
and the ...
7
Enzyme Induction and Modulation
From the preceding discussion, it can be concluded that the levels of
ribonucleotide reductase protein fluctuate during the cell cycle. The high levels of
activity are manifested in tissues of rapid growth rate such as embryonic tissue, ...
8
Frontiers in Anti-Cancer Drug Discovery, Volume (1)
A compre-hensive model for the allosteric regulation of mammalian
ribonucleotide reductase. Functional consequences of ATP- and dATP-induced
oligomerization of the large subunit. Biochemistry 2002; 41: 462-474. Kashlan
OB ...
Atta-ur-Rahman, M. Iqbal Choudhary, 2010
9
Medicinal Chemistry of Anticancer Drugs
O HO HO P-O O-P-P O HO HO P-O NH2 O HO HO P-O NH NH2 O
Phosphoribosyl pyrophosphate Glutamic acid Glutamine Glycine + ATP ADP +P
10-formyl-THF PRPPamidotransferase Phosphoribosylamine Glycinamide
ribonucleotide O ...
Carmen Avendano, J. Carlos Menendez, 2008
10
Advances in Enzyme Regulation
Ikeler TJ. Patd GF, Garsky V. Uncapher C. Yamanaka G. McClements WL.
Substituted penta- and hexapeptidcs as potent inhibitors of Herpes simplex virus
type 2 ribonucleotide reductase. Bioorg Med Chem Lett 1992;2:1207-12. Cohen
EA.
George Weber, Catherine E. Forrest Weber, 2005
WIADOMOŚCI, KTÓRE ZAWIERAJĄ SŁOWO «RIBONUCLEOTIDE»
Sprawdź, o czym dyskutuje się w prasie krajowej i zagranicznej oraz jak jest stosowane słowo
ribonucleotide w wiadomościach.
Novonco Pharmaceuticals Teams with City of Hope to Build Better …
The small molecule COH29 inhibits the production of ribonucleotide reductase (RNR), an enzyme that is central to production of many types of cancer cells. «PharmiWeb.com, Lip 15»
BEAT BioTherapeutics' BB-R12 Provides Significant Improvement in …
Results from earlier studies have shown that increasing the activity of the protein ribonucleotide reductase (RNR) in the heart leads to improved cardiac ... «Business Wire, Cze 15»
Making Sense of the Chemistry That Led to Life on Earth
He and colleagues have spent the last six years doing experiments to see how the ribonucleotide chemistry pathway can be linked back to hydrogen cyanide as ... «New York Times, Maj 15»
Slowing premature ageing
López-Contreras et al. have shown that mice carrying extra alleles of the regulatory subunit of the ribonucleotide reductase complex (RRM2TG) have increased ... «Nature.com, Kwi 15»
Caris Life Sciences Demonstrates Clinical Utility of Tumor Profiling …
The TP53-mutated samples exhibited significantly higher expression of topoisomerase 2A (TOPO2A), thymidylate synthase (TS) and ribonucleotide reductase ... «PR Newswire, Mar 15»
“RNA World” May Have Been “RNA-Protein-Lipid World”
Earth's prebiotic conditions could have included a common chemistry for ribonucleotides, amino acids, and lipids.The key starting ingredient? Hydrogen cyanide ... «Genetic Engineering & Biotechnology News, Mar 15»
Georgia Tech Group, Others Develop Methods to Map …
Along with the two other techniques, published elsewhere today, it could help researchers understand how ribonucleotides change the structure and function of ... «GenomeWeb, Sty 15»
Researchers use ancient gene to study virus biology
Researchers at the University of Delaware have discovered that an ancient gene—ribonucleotide reductase (RNR), which occurs in all cellular life—provides ... «Phys.Org, Paz 14»
Researchers at UD use ancient gene to study virus biology
8:39 a.m., Oct. 14, 2014--Researchers at the University of Delaware have discovered that an ancient gene -- ribonucleotide reductase (RNR), which occurs in all ... «UD Daily, Paz 14»
CWRU summer biomedical program, in 13th year, transforms high …
But soon, she will be able to speak authoritatively about researching an enzyme called ribonucleotide reductase (RNR for short) that catalyzes the formation of ... «The Plain Dealer, Lip 14»
